The Gut Microbiota Dysbiosis in Preeclampsia Contributed to Trophoblast Cell Proliferation, Invasion, and Migration via lncRNA BC030099/NF-κB Pathway by Rong Tang, Gong Xiao, Yu Jian, Qiongjing Yuan, Chun Jiang, Wei Wang

“…CCK-8 and Transwell assays were performed to determine cell proliferation, migration, and invasion. Western blot was utilized to evaluate MMP2, MMP9, snail, and E-cadherin, p-IκBα, IκBα, and nuclear NF-κB p65 levels. …”
Get full text

Improving the publication activity of Ukrainian scientists: problems, solutions, the use of mathematical and statistical methods by S. O. Serbenyuk

“…Moreover, such issues are even raised in the works of scholars from developed Western countries. The range of such studies is extremely wide: from analysing problems and violations of the above-mentioned principles of law to modelling innovative grant support systems, including those that model an equal and fair system. …”
Get full text

The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Human AAT also lowered the expressions of interferon signature genes. Western blot analysis showed that hAAT reduced the expression of the active form (cleaved) of TLR9 in DCs, indicating a novel mechanism of hAAT function in the immune system. …”
Get full text

The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach by Huibin Ma, Zhou Xie, Lina Huang, Yanyan Gao, Linlin Zhan, Su Hu, Jiaxi Zhang, Qingguo Ding

Get full text

Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…Then, the line where the extract was the most active was selected to evaluate the expression of certain genes involved in cancerogenesis by RT-PCR and the expression of cleaved caspase-3 involved in cell death mechanism by western blot. The AE-Ac showed the best scavenging activity with IC50s of 0.52 and 0.02 for DPPH● and NO●, respectively. …”
Get full text

Congestive heart failure adherence redesign trial: a pilot study by Ashvarya Mangla, Rami Doukky, Lynda H Powell, Elizabeth Avery, DeJuran Richardson, James E Calvin

Get full text

Clinical Characteristics of Snakebite Envenomings in Taiwan by Yan-Chiao Mao, Po-Yu Liu, Kuo-Lung Lai, Yi Luo, Kuang-Ting Chen, Chih-Sheng Lai

Get full text

Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

Get full text

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…The anti-proliferative, anti-migratory, anti-invasive and pro-apoptotic effects of hERG activators were evaluated using the Cell Counting Kit-8, wound healing assay, transwell assay and cell apoptosis assay, respectively. Western blotting, Ca2+ imaging and immunofluorescence assays were employed to study their antitumor mechanisms of actions.ResultsWe identified two novel hERG activators, SDUY429 and SDUY436, which effectively inhibited the proliferation and migration of MDA-MB-231 and MCF-7 cells. …”
Get full text

Heterozygous pathogenic STT3A variation leads to dominant congenital glycosylation disorders and functional validation in zebrafish by Linxue Meng, Zhixu Fang, Li Jiang, Yinglan Zheng, Siqi Hong, Yu Deng, Lingling Xie

“…Asp167Tyr) was identified, and the Western blot results revealed a significant decrease in protein levels. …”
Get full text

Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa by Tandi E. Matsha, Carmen Pheiffer, Stephen E. Humphries, Junaid Gamieldien, Rajiv T. Erasmus, Andre P. Kengne

Get full text

Anatomical simulation analysis of pancreaticobiliary junction in occult pancreaticobiliary reflux: based on Fluent study by LÜ Beining, HOU Nianzong, XIANG Yukai, DA Xuanbo, YANG Yulong, TIAN Fuzhou

Get full text

LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment by Enzi Feng, Xinyu Yang, Jie Yang, Qianqian Qu, Xiaojiang Li

“…We predicted LAMB1’s effect on treatment using TIDE, CTRP, and CellMine databases. Finally, Western blot, CCK-8, Transwell, and Wound scratch were employed to validate LAMB1’s effect on NPC cells. …”
Get full text

The Development of the Radial Bow in Children: Normative Values by Samara F. Kass, Julia L. Conroy, Alisa Forsberg, Rebecca S. Li, Catherine C. May, Natasha S. McKibben, Julio J. Jauregui, Raymond W. Lui, Joshua M. Abzug

Get full text

Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease by Natalie K. Kozij, John T. Granton, Philip E. Silkoff, John Thenganatt, Shobha Chakravorty, Sindhu R. Johnson

Get full text

المکتبات الخضراء ودورها فى مواجهة تحدیات الاستدامة البیئیة : دراسة تحلیلیة مقارنة by د. مها لؤى حاتم

“…The least effective stepsfor sustainability can have a significant impact on the overall picture of libraries.With a small funding, the library gets significant returns as a result of marketing.Achieving environmental awareness does not necessarily require significant effortor substantial funds, but also effective activities in developing joint relationshipswith other institutions, library friend groups, school projects, suppliers and librarybeneficiaries.The problem of the study lies in, the spread of the phenomenon of greenlibraries at the level of many developed countries in the Western world, andactivates its components at the level of the Arab world, which calls forextrapolation of the elements of environmental sustainability and therequirements of their application to various categories of libraries. …”
Get full text

The terrestrial arthropods of Rapa Nui: A fauna dominated by non-native species by J. Judson Wynne, Francis G. Howarth, Darko D. Cotoras, Sergio Rothmann, Sergio Ríos, Carolina Valdez, Pedro Lazo Hucke, Cristian Villagra, Luis Flores-Prado

Get full text

Dental profiling in the archaeological sample of the Illyrian population in Southern Dalmatia, Croatia by Marina Marić, Jelena Dumančić, Marin Vodanović, Igor Borzić, Dinko Radić, Davorka Radovčić, Hrvoje Brkić

“…The individuals examined were native residents of the island and can be associated through their dental morphology with the Western Eurasian population group. The average lifespan of the population corresponds to the typical life expectancy during the Late Iron Age.…”
Get full text

A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

Get full text

A comparative evaluation of haematological and biochemical parameters of Nemipterus randalli and Pagellus erythrinus species living in Gökova Bay, Türkiye by Rifat Tezel, Ümit Acar, Sercan Yapıcı

“…This study aims to determine and compare the reference values of the haematological and biochemical blood parameters of two fish species collected from the Gökova Bay (Muğla, South-Western of Türkiye): the non-native and invasive Randall’s threadfin bream, Nemipterus randalli and the native Common pandora, Pagellus erythrinus. …”
Get full text