Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

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1941 (pre-war half-year period): changes in the NKVD structure of the Ukrainian Soviet Socialist Republic by V. A. Grechenko

“…The author believes that the intensification of attention on this issue was largely due to the mainstreaming the activities of the nationalist underground in Western Ukraine.…”
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Mechanisms of (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (huang qi) and (Oliv.) Diels (dang gui) in Ameliorating Hypoxia and Angiogenesis to Delay Pulmonary Nodule Malignant Tra... by Ying Guo PhD, Peng Yang MS, Zihong Wu PhD, Sanyin Zhang PhD, Fengming You PhD

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LINC02389/miR-7-5p Regulated Cisplatin Resistance of Non-Small-Cell Lung Cancer via Promoting Oxidative Stress by Peng Ma, Wen Han, Cunying Meng, Xiaohong Tan, Pengfei Liu, Lei Dong

“…Materials and Methods. qRT-PCR and Western blot were performed to detect the expression of LINC02389 and miR-7-5p in NSCLC tissues and cell lines. …”
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Melatonin attenuates MPP+-induced autophagy via heat shock protein in the Parkinson’s disease mouse model by Yinli Guo, Chengbo Liu

“…Dopamine transporter (DAT) expression in the striatum was analyzed by immunohistochemistry, and Western blot was used to measure autophagy proteins and HSP70 levels. …”
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Pooled prevalence and subgroup variations of Tetralogy of Fallot among children and adolescents with congenital heart defect in Sub-Saharan Africa: A systematic review and meta-ana... by Biniam Endale Geleta, Abay Mulu

“…<h4>Results</h4>Thirty-one studies included encompassing a total of 11,265 participants from 15 Sub-Saharan African countries with representation from Southern (4 studies, 619 participants), Central (5 studies, 2,220 participants), Eastern (11 studies, 3,384 participants), and Western (11 studies, 5,042 participants). Cross-sectional studies comprised (25 studies, 8,909 participants), and cohort design (6 studies, 2,356 participants). …”
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Astronomaly Protege: Discovery through Human-machine Collaboration by Michelle Lochner, Lawrence Rudnick

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Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma by Xiong SS

“…The ferroptosis inhibitor (Liproxstatin-1) was used to study the effect of compound 6c in inducing ferroptosis. Western blot was used to observe the expression of apoptosis-related proteins. …”
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The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…In this study, the outcomes of PTP1B inhibition using trodusquemine (MSI-1436) on key equine metabolic syndrome (EMS)-related alterations including inflammation, fibrosis, and glucose uptake have been analyzed in liver explants collected from EMS-affected horses using various analytical techniques, namely, flow cytometry, RT-qPCR, and Western blot. Results. PTP1B inhibition using trodusquemine resulted in decreased proinflammatory cytokines (IL-1β, TNF-α, and IL-6) release from liver and PBMC affected by EMS and regulated expression of major proinflammatory microRNAs such as miR-802 and miR-211. …”
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Turkic-Speaking Population on the Steppe Borderland of the Grand Duchy of Lithuania and the Crimean Khanate in the 15th – the First Half of the 16th Centuries by Vladyslav V. Hrybovskyi

“… The ethnic and demographic situation on the borderland of the Grand Duchy of Lithuania and the Crimean Khanates is analysed on the basis of narratives (Michalon Lituanus, Marcin Broniowski, Marcin Bielski, Bartosz Paprocki) and documentary sources (publications “Lithuanian Metrics”, “Archive of South Western Russia”, documents of the Russian State Archive of Ancient Acts, Central State Historical Archive of Ukraine). …”
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Integrated Identification and Efficient Use of Biodiversity in Mountainous Regions by Mehdiyeva A. M., Mahmudova Z. A., Rustamova D. F., Mansurova D., Juraeva G.

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Stakeholders' perceptions of personal health data sharing: A scoping review. by Prima Alam, Ana Bolio, Leesa Lin, Heidi J Larson

“…Most of the included studies were based within North America and Western Europe, with the United States (n = 8) and the United Kingdom (n = 7) representing the most studied countries. …”
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Sex differences in borderline personality disorder: A scoping review. by Xinyu Qian, Michelle L Townsend, Wan Jie Tan, Brin F S Grenyer

“…Most studies were conducted on western populations, mainly North American (55%) or European (33%), and there is a need for future research to also take into consideration genetic, cultural, and environmental concomitants. …”
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Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress by Yuwei Han, Guangzhi Hao, Song Han, Tingzhun Zhu, Yushu Dong, Ligang Chen, Xinyu Yang, Xiaoming Li, Hai Jin, Guobiao Liang

“…Brain edema and Evans blue extravasation were measured to evaluate blood-brain barrier permeability. Western blot and quantitative real-time polymerase chain reaction (PCR) analyses were performed to examine protein and mRNA expressions related to ER stress. …”
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Assessing the health and economic burden of obesity-related complications in East-Asian populations: implementation of risk equations in the Core Obesity Model for Japan and model... by Ichiro Tatsuno, Mark Lamotte, Laetitia Gerlier, Anamaria-Vera Olivieri, James Baker-Knight

“…Conversely, the 10-year cumulative ACS incidences predicted in a Japanese population were less than half of those in a Western population.Conclusion The Japanese COM adaptation addresses ethnicity-specific patterns of overweight/obesity, with better sensitivity to lower BMIs for several associated complications. …”
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Structural Formation, Evolution, and Genetic Mechanisms of Fault in Controlling Hydrocarbon Migration of Unconventional Rocks: A Case Study of Zhuangnan Fault by Jing Wang, Yongwei Guo, Youwei Cui, Ke Sun, Huili Chu

“…In geometry, by the closure interpretation of 43 south-north interpretation sections and 24 east-west interpretation sections, the result indicates that Zhuangnan fault zone has its special regularity and characteristic which has three-piece planar characterization (eastern part, middle part, and western part). Three types of plane combination forms are determined: arched, linear, and “S” curved type. …”
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Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2 by Lihua Wang, Lei Yang, Tingting Zhuang, Xiuqing Shi

“…Exosomes from PC cells were verified by TEM and western blotting. Treatment with the exosomal inhibitor (GW4869) prevented an increase in miR-29b expression and recused the reduced VEGF expression and tube formation and migration abilities of HUVECs cocultured with BxPC3 and AsPC-1 cells that overexpressed miR-29b. …”
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Depressive symptomatology in Brazil: perspectives of statistical and psychometrics analyses of the PHQ-9 at four time-points (2020–2023) in the COVID-19 pandemic by Andre Faro, Daiane Nunes, Derek Falk

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The effect of maintenance therapy on Crohn’s disease clinical outcomes by O. B. Schukina, E. A. Kondrashina, A. M. Kharitidis, Ye. G. Vepreva, A. G. Kharitonov, A. Yu. Baranovsky

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