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Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway
Published 2025-02-01“…Subsequently, a series of assays, including quantitative reverse transcription polymerase chain reaction (qRT-PCR), flow cytometry, scratch, invasion, and tube formation assays, were conducted to confirm STA’s capacity to impede tumor cell migration, invasion, and angiogenesis in vitro. Western blotting and flow cytometry were employed to elucidate the mechanisms through which STA exerts its effects on tumor metastasis.ResultsIn our research, STA has been shown to attenuate liver metastasis in CRC mouse models by inhibiting the polarization of macrophages to the M2 phenotype. …”
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5163
Brexit and the Future of the Special Relationship between the United States and the United Kingdom
Published 2020-11-01“…The United States as the leader of the Western world expect Great Britain not only to follow its policy but to support it, i.a. by maintaining a high level of military spending. …”
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Effectiveness of befriending interventions: a systematic review and meta-analysis
Published 2017-04-01Get full text
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Content of a wound care mobile application for newly graduated nurses: an e-Delphi study
Published 2024-05-01Get full text
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Russia and NATO’s ‘Open Door’ Policy in the Post-Bipolar Period
Published 2024-07-01“…The author argues that the Western countries, viewing the ’open door’ principle as a next phase of the containment policy under new geopolitical circumstances and reaping tangible security benefits throughout its implementation, realized at a certain point that a swift accession of post-Soviet states to NATO was unattainable, and switched attention to the Nordic countries. …”
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Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
Published 2023-01-01“…Proteome analysis and western blotting showed increased expression of leucine-zipper-like transcription regulator 1 (LZTR1) and decreased expression of R-RAS and phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) in the knockout mice. …”
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Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review.
Published 2024-04-01“…Most of the research efforts concentrated on diagnosing Ascaris infections in both humans and pigs, primarily using ELISA and western blot technologies. Almost all records targeted antibodies as analytes, employing proteins and peptides as analyte detection agents. …”
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Cost Effectiveness Analysis of Eribulin Mesylate as a Treatment for Metastatic Breast Cancer in Spain: Management in the Later Line of Therapy
Published 2015-10-01“…**Background:** Two thirds (62%) of metastatic breast cancer (MBC) patients in Western Europe have human epidermal growth factor receptor 2 (HER2)-negative disease, for which anthracyclines and taxanes are recommended as first-line treatments, followed by microtubule-targeting agents such as capecitabine, vinorelbine and/or eribulin. …”
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Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease
Published 2018-01-01“…We evaluated abnormal involuntary movement every 20 min during a 3 h period following the injection of drugs on treatment Days 1, 8, and 15. Western blot analyses for dopamine decarboxylase and vesicular monoamine transferase-2 were performed using striatal tissues in the lesioned side of rats in the levodopa only group (n = 6) and levodopa plus zonisamide group (n = 4). …”
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PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
Published 2023-01-01“…Metabolic gene and protein expression were assessed via quantitative real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Media BCAA content was assessed via liquid chromatography–mass spectrometry (LC/MS). …”
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The impact of digital technologies on modern society. An example of a social credit rating system in China
Published 2020-10-01“…A critical analysis of the foundations of the system from the point of view of Western democracy values has been carried out. An overview of development prospects of the studied system and the assessment of the risks associated with it have been made. …”
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Long Noncoding RNA SNHG4 Attenuates the Injury of Myocardial Infarction via Regulating miR-148b-3p/DUSP1 Axis
Published 2022-01-01“…The expression of relating genes was measured by qRT-PCR and/or western blot. In vitro, cell viability was detected by MTT assay, and cell apoptosis was assessed by caspase-3 level, Bax/Bcl-2 expression, and/or flow cytometry. …”
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The Interannual Relationship between the Diabatic Heating over the South Asia and the Snow Depth over the Southern Tibetan Plateau in Late Spring to Early Summer: Roles of the Air...
Published 2023-01-01“…During P1, the diabatic cooling from the southern Bay of Bengal eastward to the western South China Sea suppresses convection over the Bay of Bengal and southern TP and has resulted in an upper-level anomalous cyclone and cold temperature anomalies from the surface to 200 hPa over the southern TP, favoring the above-normal SD over the southern TP. …”
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AID PROHIBITION AS A TOOL OF THE U.S. FOREIGN POLICY: DE JURE AND DE FACTO
Published 2019-01-01“…Nonetheless, the impact of the U.S. aid prohibition as a tool of coercion has been declining because of strengthening of non-Western donors – especially, China, Arab countries, Turkey and Russian Federation.…”
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The Arctic Lobby in Japan: Structures, Mechanisms of Infl uence and the Role in Developing Cooperation with the Russian Federation
Published 2020-12-01“…The decision of the Japanese government to join the Western anti-Russian sanctions disrupted these plans. …”
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Elevation of Circulating miR-210 Participates in the Occurrence and Development of Type 2 Diabetes Mellitus and Its Complications
Published 2022-01-01“…Meanwhile, the expression of carbohydrate responsive element binding protein (ChREBP) and hypoxia-inducible factor 1α (HIF-1α) was measured by western blotting. Results. The miR-210 level in exosomes from serum was obviously elevated in the BMI>24 group compared with the BMI≤24 group. …”
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