The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…IntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited efficacy in certain patients and are associated with adverse effects, which highlights the need for safer and more effective therapeutic approaches. …”
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Structural Controls of Uranium Mineralization in the Basement of the Athabasca Basin, Saskatchewan, Canada by Antonio Benedicto, Maher Abdelrazek, Patrick Ledru, Cameron MacKay, Dwayne Kinar

“…The Sue deposits (McClean Project), the Tri-Island showing (Martin Lake Project) in the Eastern Athabasca, and the Spitfire prospect (Hook Lake Project) in the Western Athabasca have been selected for a detailed analysis of structures and related uranium mineralization. …”
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Phytocanabinoids and synthetic cannabinoids: from recreational consumption to potential therapeutic use – a review by Helena M. Teixeira, Helena M. Teixeira

“…Cannabinoids are part of the most popular group of illicit substances in the Western world. The word “cannabinoid” refers to any chemical substance, regardless of structure or origin, that binds to the body’s cannabinoid receptors and that has effects similar to those produced by the Cannabis plant. …”
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Plio–Quaternary Tectonic Activity in the Northern Nubian Belts: The Main Driving Forces by Enzo Mantovani, Marcello Viti, Daniele Babbucci, Caterina Tamburelli

“…It is suggested that the occurrence of tectonic activity in the northern Nubian belts (Tell-Rif and Atlas systems) since the Late Pliocene can be interpreted as one of the processes that were produced in the central and western Mediterranean zones by the collision of the Adriatic continental promontory with the Anatolian–Aegean Tethyan system. …”
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Characterizing the deformation, failure, and water-conducting fractures evolution of shallow weakly cemented overburden under coal mining by Zhenhua Li, Yandong Zhang, Xuefeng Gao, Xuefeng Gao, Dan Ma, Dan Ma, Limin Fan, Guodong Li, Xiaolei Li, Min He, Zheng Cheng

“…Understanding the collapse mechanisms of shallow, multi-layered, weakly cemented overburden is key to safe and efficient coal mining in central and western China. Hence, we conducted a meter-scale similar physical model experiment using high-resolution digital speckle technology to replicate the deformation and failure patterns of shallowly buried, weakly cemented overburden under mining activities, and to determine the initiation, development, and stability of water-conducting fractures. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The objective is to recruit 1000 participants (aged 60–99 years) living in the western region of Singapore within a period of 3 years (2018–2020). …”
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Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro by Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang

“…In APP/PS1 mice, erastin-damaged HT22 cells, and LPS-exposed BV2 cells, the neuroprotective effects against ferroptosis and neuroinflammation were investigated using immunohistochemistry, label-free proteomics, western blot, ELISA, MTT, fluorescence, and TEM. IFY alleviated the expression levels of NO, IL-6, and IL-1β in LPS-exposed BV2 cells and improved the morphology of mitochondria in erastin-damaged HT22 cells. …”
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Investigation of the osteogenic effects of ICA and ICSII on rat bone marrow mesenchymal stem cells by Zhangshun Yao, Weixiang Huang, Yan Yang, Leiyan Zou, Yunpeng Zhang, Jing Zhang, Guangming Luo

“…Subsequently, we compared the vascularization and osteogenic capacity of the two groups through alizarin red staining assay, Western Blot, and RT-PCR. Subsequently, we assessed the phosphorylated and non-phosphorylated expression of JNK, ERK1/2, P38, and AKT at different time intervals. …”
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MOMAST^® Downregulates AQP3 Expression and Function in Human Colon Cells by Ines Angelini, Mariangela Centrone, Giusy Rita Caponio, Annarita Di Mise, Andrea Gerbino, Marianna Ranieri, Giovanna Valenti, Grazia Tamma

“…Confocal studies and Western Blotting analysis demonstrated that treatment with MOMAST^® significantly decreased the staining and the expression of AQP3. …”
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Self-organized criticality and urban development by Michael Batty, Yichun Xie

“…We illustrate the theory using a unique space–time series of urban development for Buffalo, Western New York, which contains the locations of over one quarter of a million sites coded by their year of construction and dating back to 1773, some 60 years before the city began to develop. …”
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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Accordingly, rat C6 glioma cells were first transfected with pCDNA-TK and pCDNA-sr39TK, respectively, and the gene transfection efficacy was verified by immunocytochemistry and western blot analysis. Then the in vivo sensitivity of these transfected C6-TK and C6-sr39TK cells to GCV was determined by 3-(4,5)-dimethylthiahiazo-(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) colorimetric assay and Hoechst-propidium iodide (PI) staining. …”
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Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells by Monia Orciani, Miriam Caffarini, Alessandra Biagini, Guendalina Lucarini, Giovanni Delli Carpini, Antonella Berretta, Roberto Di Primio, Andrea Ciavattini

“…Cells from 12 human leiomyoma and 12 normal myometrium samples of the same patients were in vitro isolated and exhaustively characterized (morphology, proliferation, cytofluorometry, differentiation, RT-PCR, immunofluorescence, immunohistochemistry, and Western blotting assays). Selected cytokines (ELISA) and inflammation-related genes (RT-PCR) were analyzed to identify healthy myometrium progenitor cells (MPCs) and leiomyoma progenitor cells (LPCs). …”
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Identity and Distribution of <i>Triglops metopias</i> (Teleostei, Cottidae) in the Northwestern Pacific by Artem M. Prokofiev, Ilyas N. Mukhametov, Olga R. Emelianova, Svetlana Yu. Orlova, Alexei M. Orlov

“…This species has been previously recorded only from off the Aleutian Islands and the Gulf of Alaska, while previous records from the western North Pacific have been controversial. The presence of <i>T. metopias</i> in the northwestern Pacific off the Kuril Islands is confirmed in the current study. …”
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Global, regional, and national epidemiology of allergic diseases in children from 1990 to 2021: findings from the Global Burden of Disease Study 2021 by Jun Zheng, Yi-jing Jin, Cheng-hai Wang, Chu Feng, Xin-yuan Lai, Shu-qing Hua, Jia-hui Tai

“…Geographic variations were notable: High-income North America showed the highest asthma incidence, while Western Europe led in AD prevalence. The global burden of asthma-related DALYs declined from 6.9 million in 1990 to 4.6 million in 2021, with significant regional disparities. …”
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ISLAM AND NEO-MODERNISM IN INDONESIA: REVISITING NURCHOLISH MADJID AND ABDURRAHMAN WAHID’S THOUGHT ON CIVIL SOCIETY by Dito Alif Pratama

“…This paper examines the interpretation of Madjid, who studied in a more Western academic culture, and Wahid, who studied in a Middle-Eastern country, on civil society as the manifestation of both Neo-Modernism's thought, followed by a discussion on the similarities and differences between the two ideas. …”
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Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

“…We propose establishing additional protected areas in the Himalaya particularly in the western Himalaya for better management and conservation of endangered medicinal plants.…”
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Anxiety and depression prevalence and associated factors in patients with knee osteoarthritis by Qizhen Feng, Qizhen Feng, Mingjie Weng, Xi Yang, Min Zhang

“…Consequently, this study included 360 hospitalized patients diagnosed with KOA to examine their levels of anxiety and depression and to analyze the factors influencing these psychological states.MethodsA cohort of KOA patients from the Second Hospital of Shanxi Medical University was assessed using a general condition questionnaire, European five-dimensional health status scale (EQ5D), Western Ontario and McMaster University Osteoarthritis (WOMAC), Social Support Rating Scale (SSRS), and Hospital Anxiety and Depression Scale (HADS). …”
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Current knowledge about early childhood caries in the gulf cooperation council with worldwide reflection: Scoping review of the scientific literature (2010-2021). by Asmaa Othman Alkhtib, Hasaan G Mohamed

“…Nevertheless, the GCC region has some unique characteristics that need to be investigated to contextualize the western model of the dynamics of ECC prevention and promotion programs locally.…”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. …”
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Geochemical, Mineralogical, and Geomorphological Characterization of Ash Materials as a Tracer for the Origin of Shifting Sands near Oldupai Gorge, Ngorongoro, Tanzania by Mohamed Zengo Makongoro, Maheswara Rao Vegi, Said Ali Hamad Vuai, Michael Mwita Msabi

“…Shifting sand (SS) is a single dune-shaped mass of black ash material moving across western Ngorongoro in northern Tanzania. The moving sand has become an important tourist destination for several decades. …”
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