Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Tau uptake and degradation assays in cultured astrocytes were utilized to investigate the role of HDAC7 on astrocyte-mediated tau clearance. …”
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miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway by Jie Bian, Weizhong Ge, Zhengmei Jiang

“…Nevertheless, the specific functions of miR-26a-5p in DR are still unclear. Methods. Primary cultured mouse retinal Müller cells in exposure to high glucose (HG) were used to establish an in vitro DR model. …”
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International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions by Grant R. Tomkinson, Justin J. Lang, Lukáš Rubín, Ryan McGrath, Bethany Gower, Terry Boyle, Marilyn G. Klug, Alexandra J. Mayhew, Henry T. Blake, Francisco B. Ortega, Cristina Cadenas-Sanchez, Costan G. Magnussen, Brooklyn J. Fraser, Tetsuhiro Kidokoro, Yang Liu, Kaare Christensen, Darryl P. Leong, Mette Aadahl, Edimansyah Abdin, Julian Alcazar, Aqeel Alenazi, Bader Alqahtani, Cledir De A. Amaral, Thatiana L.M. Amaral, Alex Andrade Fernandes, Peter Axelsson, Jennifer N. Baldwin, Karin Bammann, Aline R. Barbosa, Ameline Bardo, Inosha Bimali, Peter Bjerregaard, Martin Bobak, Colin A. Boreham, Klaus Bös, João Carlos Bouzas Marins, Joshua Burns, Nadezda Capkova, Lilia Castillo-Martínez, Liang-Kung Chen, Siu Ming Choi, Rebecca K.J. Choong, Susana C. Confortin, Cyrus Cooper, Jorge E. Correa-Bautista, Amandine Cournil, Grace Cruz, Eling D. de Bruin, José Antonio De Paz, Bruno De Souza Moreira, Luiz Antonio Dos Anjos, María Cristina Enríquez Reyna, Eduardo Ferriolli, Gillian Forrester, Elena Frolova, Abadi K. Gebre, Atef M. Ghaleb, Tiffany K. Gill, Yasuyuki Gondo, M. Cristina Gonzalez, Citlali Gonzalez Alvarez, Mary K. Hannah, Nicholas C. Harvey, Jean-Yves Hogrel, Marie-Theres Huemer, Toshiko Iidaka, Lewis A. Ingram, Dmitri A. Jdanov, Victoria L. Keevil, Wolfgang Kemmler, Rose Anne Kenny, Dae-Yeon Kim, Tracy L. Kivell, Ingirid G.H. Kjær, Alexander Kluttig, Rumi Kozakai, Danit Langer, Lisbeth A. Larsen, Wei-Ju Lee, David A. Leon, Eric Lichtenstein, Bertis B. Little, Roberto Alves Lourenço, Rahul Malhotra, Robert M. Malina, Kiyoaki Matsumoto, Tal Mazor-Karsenty, Marnee J. McKay, Sinéad McLoughlin, Abhishek L. Mensegere, Mostafa Mohammadian, Virgilio Garcia Moreira, Hiroshi Murayama, Anne Murray, Anita Liberalesso Neri, Claudia Niessner, Gabriel Núñez Othón, Gabriel Olveira, Suzanne G. Orchard, Andrezj Pajak, Chan Woong Park, Julie A. Pasco, Maria E. Peña Reyes, Leani Souza Máximo Pereira, Annette Peters, Eric Tsz-Chun Poon, Margareth C. Portela, Jedd Pratt, Robinson Ramírez-Vélez, Wendy Rodríguez-García, Joanne Ryan, Mauricio A. San-Martín, Francisco José Sánchez-Torralvo, Mahnaz Saremi, Arno Schmidt-Trucksäss, Satoshi Seino, Shamsul Azhar Shah, Marc Sim, Bjørn Heine Strand, Mythily Subramaniam, Charlotte Suetta, Sophia X. Sui, Jonas S. Sundarakumar, Koya Suzuki, Abdonas Tamosiunas, Maw Pin Tan, Yu Taniguchi, Barbara Thorand, Anna Turusheva, Anne Therese Tveter, Jonathan Wagner, Dao Wang, Stuart J. Warden, Julia Wearing, Shiou Liang Wee, Leo D. Westbury, Agnieszka Wiśniowska-Szurlej, Alexander Woll, Noriko Yoshimura, Ruby Yu

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Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset by Niels G. Mede, Viktoria Cologna, Sebastian Berger, John Besley, Cameron Brick, Marina Joubert, Edward W. Maibach, Sabina Mihelj, Naomi Oreskes, Mike S. Schäfer, Sander van der Linden, Nor Izzatina Abdul Aziz, Suleiman Abdulsalam, Nurulaini Abu Shamsi, Balazs Aczel, Indro Adinugroho, Eleonora Alabrese, Alaa Aldoh, Mark Alfano, Innocent Mbulli Ali, Mohammed Alsobay, Marlene Altenmüller, R. Michael Alvarez, Richard Amoako, Tabitha Amollo, Patrick Ansah, Denisa Apriliawati, Flavio Azevedo, Ani Bajrami, Ronita Bardhan, Keagile Bati, Eri Bertsou, Cornelia Betsch, Apurav Yash Bhatiya, Rahul Bhui, Olga Białobrzeska, Michał Bilewicz, Ayoub Bouguettaya, Katherine Breeden, Amélie Bret, Ondrej Buchel, Pablo Cabrera-Álvarez, Federica Cagnoli, André Calero Valdez, Timothy Callaghan, Rizza Kaye Cases, Sami Çoksan, Gabriela Czarnek, Steven De Peuter, Ramit Debnath, Sylvain Delouvée, Lucia Di Stefano, Celia Díaz-Catalán, Kimberly C. Doell, Simone Dohle, Karen M. Douglas, Charlotte Dries, Dmitrii Dubrov, Małgorzata Dzimińska, Ullrich K. H. Ecker, Christian T. Elbaek, Mahmoud Elsherif, Benjamin Enke, Tom W. Etienne, Matthew Facciani, Antoinette Fage-Butler, Md. Zaki Faisal, Xiaoli Fan, Christina Farhart, Christoph Feldhaus, Marinus Ferreira, Stefan Feuerriegel, Helen Fischer, Jana Freundt, Malte Friese, Simon Fuglsang, Albina Gallyamova, Patricia Garrido-Vásquez, Mauricio E. Garrido Vásquez, Winfred Gatua, Oliver Genschow, Omid Ghasemi, Theofilos Gkinopoulos, Jamie L. Gloor, Ellen Goddard, Mario Gollwitzer, Claudia González-Brambila, Hazel Gordon, Dmitry Grigoryev, Gina M. Grimshaw, Lars Guenther, Håvard Haarstad, Dana Harari, Lelia N. Hawkins, Przemysław Hensel, Alma Cristal Hernández-Mondragón, Atar Herziger, Guanxiong Huang, Markus Huff, Mairéad Hurley, Nygmet Ibadildin, Maho Ishibashi, Mohammad Tarikul Islam, Younes Jeddi, Tao Jin, Charlotte A. Jones, Sebastian Jungkunz, Dominika Jurgiel, Zhangir Kabdulkair, Jo-Ju Kao, Sarah Kavassalis, John R. Kerr, Mariana Kitsa, Tereza Klabíková Rábová, Olivier Klein, Hoyoun Koh, Aki Koivula, Lilian Kojan, Elizaveta Komyaginskaya, Laura König, Lina Koppel, Kochav Koren Nobre Cavalcante, Alexandra Kosachenko, John Kotcher, Laura S. Kranz, Pradeep Krishnan, Silje Kristiansen, André Krouwel, Toon Kuppens, Eleni A. Kyza, Claus Lamm, Anthony Lantian, Aleksandra Lazić, Oscar Lecuona, Jean-Baptiste Légal, Zoe Leviston, Neil Levy, Amanda M. Lindkvist, Grégoire Lits, Andreas Löschel, Alberto López-Ortega, Carlos Lopez-Villavicencio, Nigel Mantou Lou, Chloe H. Lucas, Kristin Lunz-Trujillo, Mathew D. Marques, Sabrina J. Mayer, Ryan McKay, Hugo Mercier, Julia Metag, Taciano L. Milfont, Joanne M. Miller, Panagiotis Mitkidis, Fredy Monge-Rodríguez, Matt Motta, Iryna Mudra, Zarja Muršič, Jennifer Namutebi, Eryn J. Newman, Jonas P. Nitschke, Ntui-Njock Vincent Ntui, Daniel Nwogwugwu, Thomas Ostermann, Tobias Otterbring, Jaime Palmer-Hague, Myrto Pantazi, Philip Pärnamets, Paolo Parra Saiani, Mariola Paruzel-Czachura, Michal Parzuchowski, Yuri G. Pavlov, Adam R. Pearson, Myron A. Penner, Charlotte R. Pennington, Katerina Petkanopoulou, Marija M. Petrović, Jan Pfänder, Dinara Pisareva, Adam Ploszaj, Karolína Poliaková, Ekaterina Pronizius, Katarzyna Pypno-Blajda, Diwa Malaya A. Quiñones, Pekka Räsänen, Adrian Rauchfleisch, Felix G. Rebitschek, Cintia Refojo Seronero, Gabriel Rêgo, James P. Reynolds, Joseph Roche, Simone Rödder, Jan Philipp Röer, Robert M. Ross, Isabelle Ruin, Osvaldo Santos, Ricardo R. Santos, Philipp Schmid, Stefan Schulreich, Bermond Scoggins, Amena Sharaf, Justin Sheria Nfundiko, Emily Shuckburgh, Johan Six, Nevin Solak, Leonhard Späth, Bram Spruyt, Olivier Standaert, Samantha K. Stanley, Gert Storms, Noel Strahm, Stylianos Syropoulos, Barnabas Szaszi, Ewa Szumowska, Mikihito Tanaka, Claudia Teran-Escobar, Boryana Todorova, Abdoul Kafid Toko, Renata Tokrri, Daniel Toribio-Florez, Manos Tsakiris, Michael Tyrala, Özden Melis Uluğ, Ijeoma Chinwe Uzoma, Jochem van Noord, Christiana Varda, Steven Verheyen, Iris Vilares, Madalina Vlasceanu, Andreas von Bubnoff, Iain Walker, Izabela Warwas, Marcel Weber, Tim Weninger, Mareike Westfal, Florian Wintterlin, Adrian Dominik Wojcik, Ziqian Xia, Jinliang Xie, Ewa Zegler-Poleska, Amber Zenklusen, Rolf A. Zwaan

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Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants by Francis Adu-Amankwaah, Hleziphi V. Mpundu, Kudakwashe Nyambo, Paula Strauss, Kudzanai Ian Tapfuma, Ndivhuwo Tshililo, Motunrayo Victoria Badejo, Lawrence Mabasa, Vuyo Mavumengwana, Lucinda Baatjies

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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Intracellular cold-shock proteins CIRBP and RNA-binding motif 3 (RBM3) as well as caspases 9, 8, and 3 were also analyzed via Western blot analysis. Furthermore, inducible nitric oxide synthase (iNOS), ionized calcium-binding adaptor molecule 1 (Iba1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-1α (IL-1α), monocyte chemotactic protein 1 (MCP-1), transforming growth factor β (TGFβ), CIRBP, and RBM3 gene expressions were assessed via reverse transcription polymerase chain reaction, and TNF-α, IL-6, and IL-1β releases into the cultured supernatants were assessed via enzyme-linked immunosorbent assays (ELISA). …”
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Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Ox... by Jia Lv, Yongsheng Liu, Shuhan Jia, Yuna Zhang, Haoyang Tian, Jingyuan Li, Hui Song

“…The protein and mRNA expression levels of adherens junction molecules (VE-cadherin and β-catenin) and tight junction molecules (zona occludens-1, ZO-1) were studied using western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-PCR). …”
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Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…Additionally, the phosphorylation level of STAT6 was monitored by western blot. We engineered CAR-T cells targeting the non-functional P2X7 (nfP2X7) receptor, and co-cultured them with macrophages silencing P2X7 receptor along with OC cells. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…HL-60 cells were differentiated into neutrophil-like cells by culturing in a medium containing dimethyl sulfoxide and then stimulated with LPS. …”
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Epistemic Roots, Universal Routes and Ontological Roofs of African “Ritual Archives”: Disciplinary Formations in African Thought by Oluwatoyin Vincent Adepoju

“…This is the most poetic and one of the most imaginatively, ideationally evocative and yet tantalizingly inadequately elaborated sections of “Ritual Archives”, evoking continuities between Yoruba philosophy, òrìṣà cosmology and various bodies of knowledge across art and image theory and history, without expanding on the ideas or building them into a structure adequately responsive to the promise of the ideas projected, a foundation I contribute to developing by elucidating my understanding of the significance of the ideas and their consonance with related conceptions and issues from Asian, Western and African cultures. I also demonstrate how this section may contribute to clarification of the nature of Yoruba philosophy understood as a body of ideas on the scope of human intelligibility and the relationship between that philosophy and òrìṣà cosmology, an expansive view of the cosmos developed in relation to the philosophy. …”
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Improving community-based first response to out of hospital cardiac arrest (FirstCPR): protocol for a cluster randomised controlled trial by Sandra Ware, Blake Angell, Julie Redfern, Clara Chow, Cate Ferry, Lee Taylor, Christopher Semsarian, Adrian Bauman, Janet E Bray, Simone Marschner, Michael Nelson, Saurabh Kumar, Matthew Vukasovic, Kevin Lai, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Alan Robert Denniss, Sarah Khanlari, Ian Opperman

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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses by Tiqian Liu, Tiqian Liu, Adrian Ujin Yap, Adrian Ujin Yap, Adrian Ujin Yap, Yanyu Sun, Yanyu Sun, Yunhao Zheng, Yunhao Zheng, Tianqi Wang, Tianqi Wang, Shiya Zeng, Shiya Zeng, Zhen Liu, Xin Xiong, Xin Xiong

“…Developing and validating an East–West short-form version of the OBC should be prioritized, given the variations in oral behaviors across countries and cultures.…”
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In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA by Zhaoxing Ou, Rui Zeng, Yifan Lin, Si Zhang, Mohammad Alzogool, Peng Zeng, Yuqing Lan

“…They were transfected into primarily cultured cynomolgus monkey CM cells and TM cells. The mRNA and protein levels of IκBα were examined by using real-time quantitative polymerase chain reaction (real-time PCR) and western blot to screen a pair of candidate valid sequences with the highest inhibitory rate. …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…The expression of FAM134B, proteins associated with ER stress, autophagy and apoptosis was measured by western blot. The reactive oxygen specie (ROS) levels were evaluated by MitoSOX Red and 2′,7′-Dchlorodihydrofluorescein diacetate (DCFH-DA) probe. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Methods Secretory supernatants (hMSC-L) and cell lysate products (hMSC-M) from primary human umbilical cord mesenchymal stem cells-cultured medium were administered intranasally to mice with cerebral ischemia. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…However, the role of ELA in promoting BMSCs migration and homing to injured cardiomyocytes remains unclear.MethodsPrimary BMSCs and neonatal rat ventricular myocytes (NRVMs) were isolated and cultured. NRVMs were exposed to H/R to mimic the microenvironment of AMI in vitro. …”
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Çin Siyasi Düşüncesi ve Siyasi Tarihi Bağlamında Çinli Siyasi Elitler by Tuğrul Keskin

“…The text then addresses the challenges posed by the Opium Wars and increased interactions with Western powers, which led to reformist movements and the rise of new political elites. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…Immunofluorescence staining, western blot, and biochemical assays were primarily employed to assess changes in both senescence- and ferroptosis-related molecules in mouse hippocampal tissues in response to each treatment. …”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

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BRICS expansion in the news coverage of member countries: a political economy perspective by Fedaa Mohamed Abdelaziz Abdeldayem, Sarah Francis Wadie Kswat

“…The findings promote cross-cultural understanding within BRICS nations, encouraging cooperation. …”
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