The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglyc... by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Additionally, a co‐culture system of THP‐1 and chondrocytes was established to investigate the impact of CBR‐470‐1 on chondrocyte proliferation, apoptosis, migration and the regulation of chondrocyte‐related proteins within the system. …”
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‘Empty signifier’: The concept of ‘populism’ in the contemporary mainstream political science by L. G. Fishman

“…The paper shows that this discourse emerged from the overlapping narratives of transition, modernization, free market, unlimited economic growth and ‘the end of history’ and establishes an hierarchy of global knowledge based on three principles: Western dominance, capitalism and liberalism. The author emphasizes that within this theoretical framework non-Western populism is portrayed as a relatively progressive phenomenon, as a means and an indicator of progress towards capitalism and democracy. …”
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An Autoethnography of an Islamic Teacher Education Programme by Ozan Angin

“…This approach challenges Western positivism, promoting epistemic reflexivity, and offering critical insights into marginalised perspectives and educational practices. …”
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The “Heretics” Hermeneutics: Bosnia and Balkan Bogomils in the Mirror of Modern Hungarian Literature As Potential(Borrowed?) Theaters of Multidimensional Orientalism by Marton Ivanyi

“…While not explicitly tied to imperial expansionist ambitions, such representations reflect European tendencies of “Othering,” where the “heretics” – often dismissed as heretics, tribal, or primitive – were situated in opposition to Western or Catholic norms. This dynamic was further complicated by Hungary’s intermediary status between Western Europe and the Balkans, creating a cultural and epistemological space that was neither fully “Orientalized” nor wholly part of the Western Occident. …”
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Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…Reverse-transcriptase quantitative real-time PCR (RT-qPCR) and Western blot were performed to detect gene and protein expressions. …”
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circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation by Ming Chen, Yeqing Yang, Junkai Zeng, Zilong Deng, Buling Wu

“…Isolated hDPSCs were cultured in essential and odontogenic medium. Total RNA was extracted after 14 days of culture, and then, microarray analysis was performed to measure the differential expressions of circRNAs. …”
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East Central Europe in the Federalist-Regional Concepts of the Polish Emigrants of the Second Half ofthe 20th century by Barbara Stankevič

“…In it, he suggested dividing Europe not into two or three but into four parts - Western, Eastern, West Central, and East Central. …”
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Music Drama as a Christian Parable: Mozart’s <i>Idomeneo</i> by Nils Holger Petersen

“…In modern times, ecclesiastical boundaries and religious doctrines often seem to matter little in the music and theater culture of the Western world; classical opera is often staged more in order to respond to contemporary political or social issues than to communicate the original intentions of its creators (the so-called <i>Regieoper</i>). …”
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Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

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Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901 by Zhiying Ai, Jingjing Shao, Xinglong Shi, Mengying Yu, Yongyan Wu, Juan Du, Yong Zhang, Zekun Guo

“…Embryonic stem cells (ESCs) have the ability to grow indefinitely and retain their pluripotency in culture, and this self-renewal capacity is governed by several crucial molecular pathways controlled by specific regulatory genes and epigenetic modifications. …”
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Dental profiling in the archaeological sample of the Illyrian population in Southern Dalmatia, Croatia by Marina Marić, Jelena Dumančić, Marin Vodanović, Igor Borzić, Dinko Radić, Davorka Radovčić, Hrvoje Brkić

“…The individuals examined were native residents of the island and can be associated through their dental morphology with the Western Eurasian population group. The average lifespan of the population corresponds to the typical life expectancy during the Late Iron Age.…”
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Protein C deficiency with recurrent systemic thrombosis associated with compound heterozygous PROC missense variants by Mikio Shiba, Shuichiro Higo, Yu Morishita, Yasuhiro Ichibori, Yoshihiro Kin, Yasushi Sakata, Yoshiharu Higuchi

“…PCR amplification of genomic DNA spanning these exons followed by Sanger sequencing analysis revealed that the c.76G>A and the synonymous c.423G>T variants were in the same allele, whereas the c.1000G>A variant was on the opposite allele, indicating compound heterozygosity. Western blot analysis of Huh-7 and HEK293T cells transfected with expression vectors encoding PROC with or without these variants demonstrated that Gly334Ser-PROC expression levels were significantly decreased in culture media collected from HEK293T cells, while the expression levels of protein C with these variants were not significantly altered in cell lysates. …”
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Effects of Polygonatum sibiricum Polysaccharides (PSP) on Human Esophageal Squamous Cell Carcinoma (ESCC) via NF-κB Signaling Pathway by Weizheng Zhou, Jiang Hong, Ji Zhu, Xiaowei Wang

“…The proliferation rate of Eca109 cells in each group was measured with the CCK8 assay, and the apoptosis rate in each group was analyzed by flow cytometry; the in vitro scratch assay was used to determine the migration ability of Eca109 cells after PSP treatment; the expression levels of IL-1, IL-6, IL-10, TNF-α, and TGF-β were measured by RT-PCR, and the expression levels of TLR4 and proteins that are related to NF-κB signaling pathways were determined by Western blot. Results. PSP significantly inhibited the proliferation of Eca109 cells (p<0.05) on a time- and dose-dependent manner; the apoptosis rates of Eca109 cells in experimental groups were significantly increased after 48 h of culture (p<0.05); PSP significantly reduced the migration and invasion ability of Eca109 cells (p<0.05); RT-PCR results showed that the expression of IL-10 in Eca109 cells increased significantly after treatment with PSP (p<0.05), while the expression of IL-1, IL-6, TNF-α, and TGF-β decreased significantly (p<0.05). …”
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In Vitro Studies of Bacterial Cellulose and Magnetic Nanoparticles Smart Nanocomposites for Efficient Chronic Wounds Healing by Bianca Galateanu, Mihaela-Cristina Bunea, Paul Stanescu, Eugenia Vasile, Angela Casarica, Horia Iovu, Anca Hermenean, Catalin Zaharia, Marieta Costache

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The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation by Cuizhe Wang, Meixiu Zhang, Jinxiu Wu, Wei Li, Xiaodan Ha, Yajuan Gu, Bo Han, Jianxin Xie, Jun Zhang

“…Methods. qRT-PCR and Western blot were used to detect the mRNA and protein expression levels of TLR9, KLF4, and key inflammation-related factors. …”
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Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease by Rattana Summat, Pornthip Waiwut, Supawadee Daodee, Natsajee Nualkaew, Khemjira Phemphunananchai, Puguh Novi Arsito, Yaowared Chulikhit, Orawan Montakantirat, Charinya Khamphukdee, Chantana Boonyarat

“…Western blot analysis revealed the extract and its major active component, baicalein, downregulated pro-apoptotic markers (cleaved caspase-3, and BAX) upon H₂O₂ exposure. …”
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Geopedology as base information to forest suitability zoning in a catchment of norwestern patagonia, argentina by Maria Cristina Frugoni, Romina González Musso, Gabriel Falbo, Dolores Zapiola

“…Lithology (parent material) corresponds to holocene volcanic ash in the western sector of the study area, while the eastern sector is dominated by tuff. …”
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Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves’ Orbitopathy by Chao Ma, Haoyu Li, Wei Liu, Shuwen Lu, Xian Li, Jinyuan Chen, Kaijun Li, Wenzhan Wang

“…Flow cytometry apoptosis detection, TUNEL detection, and lactate dehydrogenase detection were used to analyze the level of apoptosis. Western blotting detection was utilized to examine the regulatory pathway of oxidative stress, apoptosis, and autophagy-related proteins. …”
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Wpływ prawa rzymskiego na kształtowanie się wybranych instytucji prawa ukraińskiego — uwagi na marginesie art. 291 k.p.k. by Wojciech J. Kosior

“…The research aims to demonstrate that, despite the enormous influence of Russian, and later Soviet, legal solutions, Ukrainian law (basically newly reshaped since 1991) is part of the trends of European legal culture as a result of the implementation of Western solutions.…”
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Effects of Ginsenoside Rg1 Regulating Wnt/β-Catenin Signaling on Neural Stem Cells to Delay Brain Senescence by Yue Xiang, Shun-he Wang, Lu Wang, Zi-ling Wang, Hui Yao, Lin-bo Chen, Ya-ping Wang

“…The whole brain of Nestin-GFP transgenic newborn rat was extracted, and NSCs were extracted and cultured to P3 generation. The following indicators were detected: (1) NSC culture identification, (2) the effect of LiCl on the proliferation and survival rate of NSCs, (3) the effect of ginsenoside Rg1 on the proliferation and survival of NSCs, (4) the growth of NSCs in each group observed by an optical microscope, (5) the cell cycle of each group detected by flow cytometry, (6) the proliferative ability of each group detected by BrdU, (7) the fluorescence intensity of Nestin and Sox2 of NSCs in each group observed by a fluorescence microscope, (8) the positive rate of senescence staining analyzed by SA-β-Gal staining, (9) the localization of β-catenin in NSCs observed by laser confocal microscopy, and (10) the changes of the Wnt/β-catenin pathway-related proteins in each group detected by Western blotting. …”
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