Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation by Paul Coupland, Tamir Chandra, Mike Quail, Wolf Reik, Harold Swerdlow

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A high‐resolution genomic analysis of multidrug‐resistant hospital outbreaks of Klebsiella pneumoniae by Hao Chung The, Abhilasha Karkey, Duy Pham Thanh, Christine J Boinett, Amy K Cain, Matthew Ellington, Kate S Baker, Sabina Dongol, Corinne Thompson, Simon R Harris, Thibaut Jombart, Tu Le Thi Phuong, Nhu Tran Do Hoang, Tuyen Ha Thanh, Shrijana Shretha, Suchita Joshi, Buddha Basnyat, Guy Thwaites, Nicholas R Thomson, Maia A Rabaa, Stephen Baker

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Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC by Ewan M. Harrison, Gavin K. Paterson, Matthew T.G. Holden, Jesper Larsen, Marc Stegger, Anders Rhod Larsen, Andreas Petersen, Robert L. Skov, Judit Marta Christensen, Anne Bak Zeuthen, Ole Heltberg, Simon R. Harris, Ruth N. Zadoks, Julian Parkhill, Sharon J. Peacock, Mark A. Holmes

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Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing by Annalisa Buniello, Neil J Ingham, Morag A Lewis, Andreea C Huma, Raquel Martinez‐Vega, Isabel Varela‐Nieto, Gema Vizcay‐Barrena, Roland A Fleck, Oliver Houston, Tanaya Bardhan, Stuart L Johnson, Jacqueline K White, Huijun Yuan, Walter Marcotti, Karen P Steel

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Metabonomic, transcriptomic, and genomic variation of a population cohort by Michael Inouye, Johannes Kettunen, Pasi Soininen, Kaisa Silander, Samuli Ripatti, Linda S Kumpula, Eija Hämäläinen, Pekka Jousilahti, Antti J Kangas, Satu Männistö, Markku J Savolainen, Antti Jula, Jaana Leiviskä, Aarno Palotie, Veikko Salomaa, Markus Perola, Mika Ala‐Korpela, Leena Peltonen

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Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

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Genomic surveillance reveals geographical heterogeneity and differences in known and novel insecticide resistance mechanisms in Anopheles arabiensis across Kenya by Brian Polo, Kelly L. Bennett, Sonia Barasa, Jon Brenas, Silas Agumba, Joseph Mwangangi, Lucy Wachira, Stanley Kitur, Damaris Matoke-Muhia, David M. Mburu, Edith Ramaita, Elijah O. Juma, Charles Mbogo, Eric Ochomo, Chris S. Clarkson, Alistair Miles, Luna Kamau

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Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases by Christoph J Blohmke, Julius Muller, Malick M Gibani, Hazel Dobinson, Sonu Shrestha, Soumya Perinparajah, Celina Jin, Harri Hughes, Luke Blackwell, Sabina Dongol, Abhilasha Karkey, Fernanda Schreiber, Derek Pickard, Buddha Basnyat, Gordon Dougan, Stephen Baker, Andrew J Pollard, Thomas C Darton

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IncHI plasmids, a dynamic link between resistance and pathogenicity by Minh-Duy Phan, John Wain

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Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies by Federica Eduati, Patricia Jaaks, Jessica Wappler, Thorsten Cramer, Christoph A Merten, Mathew J Garnett, Julio Saez‐Rodriguez

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SPI-7: Salmonella’s Vi-Encoding Pathogenicity Island by Helena M. B. Seth-Smith

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Age-related disparities in treatment and outcomes for newly diagnosed multiple myeloma: a population-based study by Xinhe Shan, Rowan Kuiper, Chuling Ding, Pashna N. Munshi, Edward A. Stadtmauer, Sandra P. Susanibar-Adaniya

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Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy by Borislav Dejanovic, Tania Djémié, Nora Grünewald, Arvid Suls, Vanessa Kress, Florian Hetsch, Dana Craiu, Matthew Zemel, Padhraig Gormley, Dennis Lal, EuroEPINOMICS Dravet working group, Candace T Myers, Heather C Mefford, Aarno Palotie, Ingo Helbig, Jochen C Meier, Peter De Jonghe, Sarah Weckhuysen, Guenter Schwarz

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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation by Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom

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Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche by Holly R. Foster, Maria Colzani, Guenaelle Bouet, Daniel Howard, Christian A. Di Buduo, Nicole Müller-Sienerth, Amie K. Waller, Yi Sun, Natalia Davidenko, Jennifer H. Shepherd, Thomas Moreau, Amanda L. Evans, Paolo M. Soprano, Martin E.M. Parsons, Yumi Ying Sims, Meera Arumugam, Wardiya Afshar-Saber, Ernest Turro, Patricia B. Maguire, Serena M. Best, Ruth E. Cameron, Alessandra Balduini, Gavin J. Wright, Cedric Ghevaert

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The laboratory diagnosis of enteric fever by John Wain, Salih Hosoglu

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A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space by Luke T.G. Harland, Tim Lohoff, Noushin Koulena, Nico Pierson, Constantin Pape, Farhan Ameen, Jonathan Griffiths, Bart Theeuwes, Nicola K. Wilson, Anna Kreshuk, Wolf Reik, Jennifer Nichols, Long Cai, John C. Marioni, Berthold Göttgens, Shila Ghazanfar

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Conceptual issues for screening in the genomic era – time for an update? by Caroline F Wright, Ron Zimmern

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Typhoid fever in Ethiopia by Getenet Beyene, Daniel Asrat, Yohannes Mengistu, Abrham Aseffa, John Wain

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Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. by J H Duncan Bassett, Apostolos Gogakos, Jacqueline K White, Holly Evans, Richard M Jacques, Anne H van der Spek, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Edward Ryder, David Sunter, Alan Boyde, Michael J Campbell, Peter I Croucher, Graham R Williams

“…We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice generated by the Wellcome Trust Sanger Institute Mouse Genetics Project and discover novel genes that may be involved in the pathogenesis of osteoporosis. …”
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