CIME4R: Exploring iterative, AI-guided chemical reaction optimization campaigns in their parameter space by Christina Humer, Rachel Nicholls, Henry Heberle, Moritz Heckmann, Michael Pühringer, Thomas Wolf, Maximilian Lübbesmeyer, Julian Heinrich, Julius Hillenbrand, Giulio Volpin, Marc Streit

“…Using CIME4R the experts were able to produce valuable insights from past RO campaigns and to make informed decisions on which experiments to perform next. We believe that CIME4R is the beginning of an open-source community project with the potential to improve the workflow of scientists working in the reaction optimization domain. …”
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A Speckle-Tracking Echocardiography Study: Cardiac Effect of Sleep Duration by Gülsüm Bingöl, Fulya Avcı Demir, Özge Özden, Emre Özmen, Serkan Ünlü

“…Conclusion: As a result, GLS, which is one of the parameters showing LV function, was found to be less in healthy people with a sleep time above a certain period, and we believe that this may be a hypothesis to explain the relationship of long sleep time with cardiovascular events.…”
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The Effects of Trenbolone Supplementation on The Extremity Bones in Running Rats by Ali Sarı, Sefa Lök

“…Results of this study indicate that trenbolone supplement may lead to early epiphyseal closure in femur and humerus bones of rats, ceasing the increase in their length. We believe that the results obtained from this trenbolone trial will provide important data to the studies that will be conducted on anabolic androgenic steroids.     …”
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Mathematical Model for Assessing New, Non-Fossil Fuel Technological Products (Li-Ion Batteries and Electric Vehicle) by Igor E. Anufriev, Bulat Khusainov, Andrea Tick, Tessaleno Devezas, Askar Sarygulov, Sholpan Kaimoldina

“…The latter situation allows us to determine the tracking of market saturation, which is more similar to the process that is actually occurring. We believe that this model can also be validated to estimate the production of wind turbines that use rare earth elements such as neodymium and dysprosium (for the production of powerful and permanent magnets for wind turbines). …”
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Conversational Therapy through Semi-Immersive Virtual Reality Environments for Language Recovery and Psychological Well-Being in Post Stroke Aphasia by A. Giachero, M. Calati, L. Pia, L. La Vista, M. Molo, C. Rugiero, C. Fornaro, P. Marangolo

“…Given the importance of these aspects for aphasia recovery, we believe that our results add to previous evidence which points to the ecological validity and feasibility of VR treatment for language recovery and psychosocial well-being.…”
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Erectile Function and Sexual Activity Are Declining in the Younger Generation: Results from a National Survey in Japan by Akira Tsujimura, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Masato Shirai, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Yoshikazu Sato, Atsushi Nagai, Koichi Nagao, Haruaki Sasaki

“…Conclusions: The EHS-based assessment revealed a prevalence of ED of 30.9%, which affected approximately 14 million men, and that the sexual desire, erection stiffness, orgasms, and satisfaction were lower than expected in young Japanese men, especially those aged 20 to 24 years, although those factors tended to worsen with aging. We believe that these findings actually reveal the current sexual status of men in Japan.…”

Multiplexed SSR marker analysis of Diplocarpon coronariae reveals clonality within samples from Middle Europe and genetic distance from Asian and North American isolates by Thomas Oberhänsli, Anna Dalbosco, Virginie Leschenne, Anne Bohr, Sascha Buchleither, Lucius Tamm, Lukas Wille, Srđan G. Aćimović, Fatemeh Khodadadi, Young-Hyun Ryu, Bruno Studer, Hans-Jakob Schärer, Andrea Patocchi

“…Dc has a large effective population size during field epidemics, so we believe that the pathogen has substantial evolutionary potential. …”
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ADMET evaluation in drug discovery: 21. Application and industrial validation of machine learning algorithms for Caco-2 permeability prediction by Dong Wang, Jieyu Jin, Guqin Shi, Jingxiao Bao, Zheng Wang, Shimeng Li, Peichen Pan, Dan Li, Yu Kang, Tingjun Hou

“…Matched Molecular Pair Analysis (MMPA) was utilized to extract chemical transformation rules. We believe that the model developed in this study could represent a reliable tool for assessing Caco-2 permeability during early-stage drug discovery and the chemical transformation rules derived here could provide insights for optimizing Caco-2 permeability. …”
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Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial by Patrick WHE Vriens, Edith M Willigendael, Maarten A Lijkwan, Friedo W Dekker, Chava L Ramspek, Michiel W de Haan, Çaĝdaş Ünlü, Boudewijn DC Heggen, Koen E A van der Bogt, Marc H Hemmelder, Mickaël J C Hiligsmann, Magda M van Loon, Joris I Rotmans, Jan H M Tordoir, Geert Willem H Schurink, Maarten G J Snoeijs, Marijke J Molegraaf, Philippe WM Cuypers, Denise Nio, Cora H Arts, Jacobien C Verhave, Goos D Laverman, Aron S Bode, Marcel C Weijmer, Bas Govaert, Aaltje Y Adema, Gijs MJM Welten, Michel MPJ Reijnen, Marc JH Groeneveld, Hans S Brink, Jeroen B van der Net, Arno Kuijper, Hilde PE Peters, Roos C van Nieuwenhuizen, Rombout R Kruse, Yvonne C Schrama, Karina A de Groot, Karima Farhat

“…We will enrol 195 patients to have sufficient statistical power to detect an absolute decrease of 0.80 interventions per year.Ethics and dissemination Because of clinical equipoise, we believe it is justified to randomly allocate elderly patients to the different vascular access strategies. …”
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The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…Given that the majority of the global population has acquired memory immunity against various pathogens through infection or vaccination, we believe that, in addition to utilizing the widely held immune memory against SARS-CoV-2 via COVID-19 vaccine, mRNA vaccines against other pathogens, such as Hepatitis B Virus (HBV), Common Human Coronaviruses (HCoVs), and the influenza virus, could be rapidly transitioned into clinical use and holds great promise in treating different types of cancer. …”
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Irreducible representation of surface distributions and Piola transformation of external loads sustainable by third gradient continua by dell’Isola, Francesco, Fedele, Roberto

“…In view of the obtained Piola transformation formulas, the concept of dead loads needs to be modified. We believe to have given an example of how the Mechanics in the French Style, as developed on the ideas by D’Alembert and Lagrange, is still a fertile tool of invention.…”
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Descripción de la estructura familiar de una muestra de pacientes con hemofilia. Comparación Argentina-México / Description of a Sample of Hemophilia Patients’ Family Structures: A... by Maricela Osorio-Guzmán, Silvina Graña

“…For adaptability, on the other hand, 100% of the Mexican families presented a rigid structure. Discussion: We believe that to recover a healthy balance and improve family life quality, integrated and sustained psychological intervention is required. …”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…This protocol aims to enhance standard clinical practice by introducing a program of functional re-education and environmental adaptation. We believe this intervention is essential for the follow-up care of patients with respiratory conditions after hospital discharge.…”
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The Status of Wild Grapevine (<i>Vitis vinifera</i> L. subsp. <i>sylvestris</i> (C.C. Gmel.) Hegi) Populations in Georgia (South Caucasus) by Gabriele Cola, Gabriella De Lorenzis, Osvaldo Failla, Nikoloz Kvaliashvili, Shengeli Kikilashvili, Maia Kikvadze, Londa Mamasakhlisashvili, Irma Mdinaradze, Ramaz Chipashvili, David Maghradze

“…The Georgian population of wild grapevines was found to be fragmented, often consisting of scattered single individuals or small groups. Therefore, we believe it is urgent for Georgia to implement specific protection measures to preserve this vital genetic resource.…”
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Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…Lastly, we investigated the Nasu-Hakola (NHD)-causing Y38C and V126G TREM2 as a comparison and found that they imposed greater destabilization compared to AD-causing variants. We believe that the in-silico mutagenesis methods described here can be applied broadly to evaluate the ever-growing numbers of protein mutations/variants discovered in human genetics study for their potential in diseases, ultimately facilitating personalized medicine.…”
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Evaluation of recombinant proteins <i>T. pallidum</i> Тр0163 and Тр0971 as antigens for the diagnosis of syphilis using enzyme immunoassay by Natalia V. Arbuzova, Marina V. Shpilevaya, Georgii L. Katunin, Oleg E. Kuznetsov, Nikita Yu. Nosov, Viсtoria S. Solomka

“…In order to improve the treponema-specific diagnosis of syphilis, we believe it is important to continue working with these antigens to determine the effectiveness of ELISA to detect IgG, IgM or IgM/ IgG antibodies with a large number of clinical serum samples from syphilis patients, patients with non-syphilitic pathology and healthy individuals.…”
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A Novel Convolutional Neural Network-Based Approach for Fault Classification in Photovoltaic Arrays by Farkhanda Aziz, Azhar Ul Haq, Shahzor Ahmad, Yousef Mahmoud, Marium Jalal, Usman Ali

“…Our study also highlights the importance of representative and discriminative features to classify faults (as opposed to the use of raw data), especially in the noisy scenario, where our method achieves the best performance of 70.45&#x0025;. We believe that our work will serve to guide future research in PV system fault diagnosis.…”
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The Effects of Digital eHealth Versus Onsite 2-Day Group-Based Education in 255 Patients With Irritable Bowel Syndrome: Cohort Study by Birgitte Berentsen, Camilla Thuen, Eline Margrete Randulff Hillestad, Elisabeth Kjelsvik Steinsvik, Trygve Hausken, Jan Gunnar Hatlebakk

“…Here, 41% (29/71) of patients attending the eHealth program reported a mean IBS-SSS reduction of 103 (SD 72.0) points (PPPPP ConclusionsWe conclude that the digital multidisciplinary eHealth program has a significant effect on in a portion of patients; it is useful as a tool in disease self-management and does not result in worse symptom scores than an onsite multidisciplinary 2-day group-based education program after 3 months. We believe these results indicate that a digital eHealth approach is preferable to an onsite multidisciplinary 2-day group-based education program covering the same topics.…”
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Clinical Holistic Medicine: Metastatic Cancer by Søren Ventegodt, Elin Solheim, Mads E. Saunte, Mohammed Morad, Isack Kandel, Joav Merrick

“…We believe that the consciousness-based/holistic medical toolbox has a serious additional offer to cancer patients and, as a consequence, designed a treatment for the patient with metastasized cancer. …”
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Radiography may not be accurate in assessing acute ankle sprains in children by Xiongtao Li, Xiantao Shen, Si Wang, Jie Sun, Zhaoting Liu

“…Compared with radiography, ultrasonography is highly accurate in the diagnosis of chondral avulsion fractures and ligament injuries in children. We believe that ultrasonography, as a noninvasive, radiation-free, and cost-effective dynamic diagnostic method, is particularly suitable for the early diagnosis of acute ankle sprains in children. …”
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