A Dilemma in Staging of Esophageal Cancer: How Should We Stage ypT0 N2 M0 Esophageal Cancer after Neoadjuvant Therapy? by Sebahattin Celik, Remzi Erten, Abdulsamed Batur, Burak Suvak

“…Despite the growing use of neoadjuvant treatment in locally advanced esophageal cancer in world, we do not have a protocol for the evaluation of these patients’ pathology reports. We believe that new studies and new ideas are needed to resolve this dilemma associated with neoadjuvant therapy.…”
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The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study by Doh Young Lee, Kyoung Ho Oh, Jae-Gu Cho, Soon-Young Kwon, Jeong-Soo Woo, Seung-Kuk Baek, Kwang-Yoon Jung

“…Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC.…”
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The Effect of Chewing Gum on Stress in Women with Unexplained Infertility by Ahmet Basar Tekin, Nezihe Kızılkaya Beji, Vehbi Yavuz Tokgöz, Yeliz Kaya, Tuğba Tahta, Tuğba Kartal

“…However, a statistically signifiant difference was found between the mean values of the denial of life without children, which was a subscale of the Fertility Problem Inventory score according to time in the Experimental Group - 2 group (p lt;0.005).Conclusion: We believe that the positive effect of chewing gum on coping with stress may be an alternative intervention that may contribute positively to coping with the infertility treatment process and should be supported by other interventions.…”
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Forward‐Looking Study of Solar Maximum Impact in 2025: Effects of Satellite Navigation Failure on Aviation Network Operation in the Greater Bay Area, China by Dabin Xue, Jian Yang, Zhizhao Liu, Wei Cong

“…Based on the projected flight volume in 2025 related to the GBA airports, simulation results show that the economic costs can be tens of millions of Euros, which is dependent on the duration of satellite navigation failure and the time interval of ground navigation‐based landing. We believe that this study can be a benchmark for evaluating the potential economic effects of forthcoming space weather on flight operations.…”
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An Innocent Appearing Subcutaneous Nodule Diagnoses a Small Cell Lung Cancer in a Never-Smoker Female by Nupur Sinha, Masooma Niazi, Gilda Diaz-Fuentes, Richard Duncalf

“…Cutaneous metastases from SCLC are exceptionally rare with reported incidence of 0.3% to 0.8%. We believe ours is the first reported case of SCLC presenting as subcutaneous nodule, in a never-smoker, otherwise asymptomatic female. …”
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A Regional Ionospheric Storm Forecasting Method Using a Deep Learning Algorithm: LSTM by Panpan Ban, Lixin Guo, Zhenwei Zhao, Shuji Sun, Tong Xu, Zhengwen Xu, Fengjuan Sun

“…Case studies also showed good performance during geomagnetic storms of different strengths. We believe that this model can be beneficial for functional ionospheric storm operation.…”
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Completion of a standardizable competency-based research training program improves understanding and preparedness for both new and experienced clinical research professionals by Lucy Palmer, Sandra E. Morones, Heidi T. Jacobe, Rhonda Oilepo

“…The UTSW CRF combines the existing CITI training modules with UTSW-created material, providing an optimal balance between generalized clinical research education and institutionally tailored content. We believe the UTSW CRF curriculum could serve as a plug-and-play foundational model for other research centers to tailor according to their audience and institutional needs.…”
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Nonviral targeted mRNA delivery: principles, progresses, and challenges by Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song

“…Finally, we pointed out the existing challenges and future directions with deep insights into the design of efficient mRNA delivery systems. We believe that a high‐precision targeted delivery system can greatly improve the therapeutic effects and bio‐safety of mRNA therapeutics and accelerate their clinical transformations. …”
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Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics by María S. Aymerich, J. López-Azcárate, J. Bonaventura, G. Navarro, D. Fernández-Suárez, V. Casadó, F. Mayor, C. Lluís, M. Valencia, J. Artieda, Rafael Franco

“…These results indicate that the lateral movement of receptors and receptor internalization are not directly coupled. Thus, we believe that live imaging of GPCRs using spinning disk confocal image analysis constitutes a powerful tool to study of receptor dynamics.…”
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Highly-sensitive electrochemiluminescence biosensor for detection of inosine monophosphate in meat based on graphdiyne/AuNPs/luminol nanocomposites by Jing Liu, Yizhong Shen, Guangxian Wang, Yaodong Xiang, Yemin Guo, Xia Sun, Yuan Liu

“…Moreover, we carried out the precise analysis of IMP in actual meat samples with acceptable results compared to the liquid chromatography. We believe that this work could offer an efficient ECL platform for accurate and reliable report of IMP levels, which is significant for maintaining food quality and safety.…”
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Addressing the Oncologist Shortage in Latin America: Insights From a Survey of Medical Oncology Fellowship Programs by Mauricio Zegarra-López, Alejandro Aranda-Gutierrez, Jose Felipe Muñoz Lozano, Cynthia Villarreal-Garza

“…Nearly half of the data were collected through word of mouth, as many countries lack official, publicly accessible sources for some of the variables studied.CONCLUSIONThis study serves as a pioneering effort that future research groups can build upon. We believe that addressing the shortage of medical oncologists in Latin America by increasing the number of locally trained fellows is the most effective way to swiftly and sustainably improve cancer outcomes.…”
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A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery by Annabel C. Y. Chew, Anita Chan, Monisha E. Nongpiur, Gary Peh, Veluchamy A. Barathi, Nyein C. Lwin, Charles Ong, Shamira Perera

“…There was a trend towards better endothelium preservation with the P-chute even though the results were not statistically significant. We believe that the device could be useful in certain surgical situations. …”
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Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification by Julia E. Poletaeva, Anastasiya V. Tupitsyna, Alina E. Grigor’eva, Ilya S. Dovydenko, Elena I. Ryabchikova

“…At the same time, we observed signs of a negative effect of the sucrose gradient on bio-NPs of intact and photomodified serum; when isolating these particles on a sucrose cushion, no negative effects were observed. We believe that the data we present will be useful to researchers using sucrose solutions to isolate bio-NPs and working on the properties of the protein corona. …”
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Genome wide association studies on seven yield‐related traits of 183 rice varieties in Bangladesh by Nilanjan Roy, Acramul Haque Kabir, Nourin Zahan, Shahba Tasmiya Mouna, Sakshar Chakravarty, Atif Hasan Rahman, Md. Shamsuzzoha Bayzid

“…This is the first known GWAS study on various yield‐related traits in the varieties of Oryza sativa available in Bangladesh—the fourth largest rice‐producing country. We believe this study will accelerate rice genetics research and breeding stable high‐yielding rice in Bangladesh.…”
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A Rare Case of Pneumonia Caused by Shewanella putrefaciens by Rajshree Patel, Albin Abraham, Johnson Thomas, Wanqing Zhi, Shadab Ahmed, Janice Verley

“…Patient’s pneumonia improved with treatment with cefepime. We believe that our patient developed pneumonia evidently caused by S. putrefaciens, after near drowning in sea water. …”
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Innovations in Nipple-areolar Complex Reconstruction: Evaluation of a New Prosthesis by Michele Riccio, MD, Angelica Aquinati, MD, Mario Fordellone, PhD, Nicola Carboni, MD, Andrea Marchesini, MD, Francesco De Francesco, MD, PhD

“…Encouraged by these auspicious outcomes that indicate a significant rate of safety and satisfaction, we believe that this straightforward, noninvasive, affordable medical device deserves consideration as a reconstructive option for all patients seeking breast reconstruction, promoting full body integrity.…”
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Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers by John Metzcar, Rachael Guenter, Yafei Wang, Kimberly M Baker, Kate E Lines

“…Through a cross-disciplinary approach, we believe that many currently difficult problems can be made more tractable by applying mathematical modeling and that the field of rare diseases in endocrine oncology is well poised to take advantage of these techniques.…”
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IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers by Figen Aydin, Ahmet Kaya, Levent Karapinar, Mert Kumbaraci, Ahmet Imerci, Hasan Karapinar, Cengiz Karakuzu, Mustafa Incesu

“…IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. …”
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Recurrent patellar dislocation: treatments and challenges by Fei Yang, Fei Yang, Changshun Chen, Changshun Chen, Rongjin Chen, Chenhui Yang, Hefang Xiao, Zhiwei Feng, Zhiwei Feng, Bin Geng, Yayi Xia

“…This article provides a comprehensive review of current treatments for RPD. We believe that regardless of the surgical method used, patellar dislocation should not occur at 0°–90° of postoperative knee flexion and extension, and the range of motion should not be limited. …”
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Diagnosis of Distal Cholangiocarcinoma after the Removal of Choledocholithiasis by Yasuhiro Ito, Takeshi Kenmochi, Tomohisa Egawa, Shinobu Hayashi, Atsushi Nagashima, Yuko Kitagawa

“…IDUS after stone removal may potentially help in the detection of unexpected tumors. Therefore, we believe that IDUS after stone removal will lead to improve outcome and prognosis.…”
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