Molecular imaging of viral pathogenesis and opportunities for the future by Brianna Kelly, Jeanette E. Boudreau, Steven Beyea, Kimberly Brewer

“…Since tools to study viral pathogenesis longitudinally and systemically are limited, molecular imaging is an attractive and largely unexplored tool. …”
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Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis by Jason Kerkvliet, Ramakrishna Edukulla, Moses Rodriguez

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Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis by Cristina Venturini, Judith Breuer

“…This review provides a comprehensive examination of CMV’s genetic diversity and evolution, focussing on the role of different genotypes in viral pathogenesis.…”
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TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses by Gilmara Barros de Lima, Everton Nencioni, Fábio Thimoteo, Camila Perea, Rafaela Fuzaro Alves Pinto, Sergio Daishi Sasaki

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Creation of transgenic mice susceptible to coronaviruses: a platform for studying viral pathogenesis and testing vaccines by N. R. Battulin, O. L. Serov

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Eastern equine encephalitis virus: Pathogenesis, immune response, and clinical manifestations by Bhumika Parashar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Sirajunisa Talath, Javedh Shareef

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Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice by Tianchan Peng, Jian Xiang, Yun Tian, Xiaogen Tang, Lina Wang, Lijuan Gao, Oscar Junhong Luo, Li’an Huang, Guobing Chen

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The mechanism-specific injury mortality burden associated with heatwave in China in a warming world by Jianxiong Hu, Shaoli Huang, Yulin Zhuo, Jianhua Zhang, Weiwei Gong, Guanhao He, Maigeng Zhou, Fangfang Zeng, Ruilin Meng, Tao Liu, Chunliang Zhou, Yize Xiao, Min Yu, Biao Huang, Guoxia Bai, Hua Guo, Wenjun Ma

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The Complex Role of STAT3 in Viral Infections by Suresh V. Kuchipudi

“…Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.…”
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Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility by Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin A. Yates, Ralf P. Richter, Marco Guerrini, Seraphine V. Wegner, Kay Grobe

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The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

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PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation. by Lujie Zhang, Yanni Gao, Haoran Zhou, Xiao Liang, Xiaolin Jiang, Wenqin Gong, Yangyang Sun, Desheng Zhang, Xianwei Wang, Hans Nauwynck, Juan Bai, Ping Jiang

“…The NLRP3 inflammasome is a fundamental component of the innate immune system, yet its excessive activation is intricately associated with viral pathogenesis. Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2), belonging to the family Arteriviridae, triggers dysregulated cytokine release and interstitial pneumonia, which can quickly escalate to acute respiratory distress and death. …”
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Sitagliptin: a potential drug for the treatment of COVID-19? by Bardaweel Sanaa K., Hajjo Rima, Sabbah Dima A.

“…Possible interaction of SARS-CoV-2 with DPP4 peptidase may partly contribute to the viral pathogenesis. An integrative bioinformatics approach starting with mining the biomedical literature for high confidence DPP4-protein/gene associations followed by functional analysis using network analysis and pathway enrichment was adopted. …”
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Mesenchymal Stromal Cells and Viral Infection by Maytawan Thanunchai, Suradej Hongeng, Arunee Thitithanyanont

“…However, the interplay between MSCs and virus is like a double-edge sword, and it also provides beneficial effects such as allowing the proliferation and function of antiviral specific effector cells instead of suppressing them, serving as an ideal tool for study of viral pathogenesis, and protecting hosts against viral challenge by using the antimicrobial activity. …”
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Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals by Yuanqing Wang, Yuanqing Wang, Xiaojie Jiang, Yuan Xi, Siqi Wei, Songyi Ning, Wen Zhang, Wen Zhang

“…Further research is needed to explore the functional roles of these cycloviruses in viral pathogenesis, particularly how they may influence host immunity and contribute to chronic infections. …”
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An Active-Learning Framework for Educating Medical Students on SARS-CoV-2 Variants and COVID-19 Epidemiology [version 1; peer review: 2 approved] by Samiksha Prasad, Amanda J Chase

“…The post-session survey data showed an increase in students’ understanding of the classification of COVID-19 variants and the role of genetic mutations in viral pathogenesis. Qualitative data yielded positive feedback for the session, notably in students' ability to interpret phylogenetic trees and understand the role of variants. …”
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The viral and cellular microRNA targetome in lymphoblastoid cell lines. by Rebecca L Skalsky, David L Corcoran, Eva Gottwein, Christopher L Frank, Dong Kang, Markus Hafner, Jeffrey D Nusbaum, Regina Feederle, Henri-Jacques Delecluse, Micah A Luftig, Thomas Tuschl, Uwe Ohler, Bryan R Cullen

“…To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. …”
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SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development by Fabrizio Angius, Silvia Puxeddu, Silvio Zaimi, Serena Canton, Sepehr Nematollahzadeh, Andrea Pibiri, Ilenia Delogu, Gualtiero Alvisi, Meng Ling Moi, Aldo Manzin

“…In the past four years, immense research efforts have contributed much to our understanding of the viral pathogenesis mechanism, the COVID-19 syndrome, and the host–microbe interactions, leading to the development of effective vaccines, diagnostic tools, and treatments. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…The non-structural protein p17 encoded by ARV induces cellular autophagy and facilitates viral proliferation, playing a pivotal role in viral pathogenesis. To further elucidate the pathogenic mechanism basis of ARV p17 protein function, we employed a yeast two-hybrid system to identify Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as an interacting host protein with p17. …”
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Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples by Gill Diamond, Erika L. Figgins, Denny Gao, Tanya O. Robinson, Kenneth Wilson, Jon D. Gabbard, Charles D. Anderson, Lalit Batra, Chithra Sreenivasan, Jian Zheng, Uyen Do, Braden Mulcahy, Lisa K. Ryan, Nathaniel McLaughlin, Anna H. Owings, Neha Dhaliwal, Haley B. Williams, T. Grant Wichman, Michelle Galeas-Pena, Sarah C. Glover

“…It also shows the coordinate regulation of these genes as a response to infection with SARS-CoV-2, possibly through viral pathogenesis, to increase infectivity in the gut.…”
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