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    Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins by Andrew Z. Ma, Yao Yu Yeo, Jean F. Lee, Colin M. Kim, Shahrzad Ezzatpour, Carolina Menchaca, Viraj Upadhye, Edward J. Annand, John-Sebastian Eden, Raina K. Plowright, Alison J. Peel, David W. Buchholz, Hector C. Aguilar

    Published 2025-02-01
    “…Our study reveals that HeV-g2 and HeV-g1 glycoproteins are highly conserved in identity, function, and receptor tropism, yet they differ in their abilities to induce the formation of multinucleated cells (syncytia), which is a potential marker of viral pathogenesis. By using heterotypic combinations of HeV-g2 with either HeV-g1 or NiV glycoproteins, as well as chimeric HeV-g1/HeV-g2 glycoproteins, we demonstrate that the differences in syncytial formation can be attributed to the intrinsic fusogenic capacities of each glycoprotein. …”
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