Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer: Where Are We Now? by Luís Lima, Mário Dinis-Ribeiro, Adhemar Longatto-Filho, Lúcio Santos

“…The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Guérin (the BCG vaccine). This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with high-grade tumours, T1 tumours, and in situ carcinomas. …”
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A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 by Zhe Chen, Leilei Feng, Lei Wang, Li Zhang, Binyang Zheng, Hua Fu, Fengdi Li, Ligai Liu, Qi Lv, Ran Deng, YanLi Xu, Yongfeng Hu, Jianhua Zheng, Chuan Qin, Linlin Bao, Xiangxi Wang, Qi Jin

“…With the constant evolution of the virus, Omicron and its subtypes BA.1, BA.2, BA.3, BA.4, and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or infection. This evasion highlights the urgency in discovering new monoclonal antibodies (mAbs) with neutralizing activity, especially broadly neutralizing antibodies (bnAbs), to combat the virus.In the current study, we introduced a fully human neutralizing mAb, CR9, that targets Omicron variants. …”
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De novo design of protein minibinder agonists of TLR3 by Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

“…Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and infectious disease, but present substantial manufacturing and formulation challenges. …”
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Studying immunotherapeutic properties of the conjugate based on BCG antigens with betulonic acid in guinea pigs infected with <i>Mycobacterium scrofulaceum</i> by I. N. Koshkin, V. S. Vlasenko, N. A. Dengis

“…The experiment showed that the inoculation of Mycobacterium scrofulaceum into guinea pigs activates cationic proteins and neutrophil myeloperoxidase, and on experiment day 42 (preceded by mycobacteria withdrawal from the body) their concentration reduced to the level of the control group. The vaccine administration induced a more active intracellular phagocyte metabolism during the entire observation period, which resulted in the elimination of nontuberculosis mycobacteria in animals as early as day 7 after treatment with the conjugate. …”
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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…This phenomenon, characterized by alterations in both innate and adaptive immunity, increases susceptibility to infections, reduces vaccine efficacy, and contributes to the development of age-related diseases. …”
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PHYLOGENETIC ANALYSIS OF FMDV ISOLATES RECOVERED IN POST-SOVIET STATES AND MONGOLIA IN 2016 by A. M. Timina, N. G. Zinyakov, A. V. Scherbakov, D. A. Lozovoy

“…The FGBI “ARRIAH's" objectives as a Regional Reference Laboratory/ Centre include continuous FMDV monitoring in post-Soviet states, detection of new genetic virus variants and matching their antigenic properties with antigenic properties of available vaccine virus strains. The paper demonstrates results of phylogenetic analysis of foot-and-mouth disease virus (FMDV) that caused the disease in Armenia, Zabaikalsky Krai (Russia), Middle Asia and Mongolia in 2016. …”
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Air Pollution Variation During COVID-19 Pandemic Using Satellite and On-site Measurement Data in Six Provinces in Iran by Maryam Zare Shahne, Amirhossein Noori, Mehdi Alizade Attar

“…Base on wavelet transform, implemented on ground-measurment of PM2.5, the PM2.5 concentration increased in early 2021 from the value in baseline period, due to eased restriction and expansion of public COVID-19 vaccine in all considered provinces.…”
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Serotypes and antimicrobial resistance of Streptococcus pneumoniae in Chinese pediatric population: a scoping review by Xu Han, Haiyang Yu, Niurka Molina Águila, María Eugenia Toledo Romaní

“…It is concluded that the pneumococcal conjugate vaccine 13 has high coverage in Streptococcus pneumoniae serotypes in children from mainland China, therefore its inclusion in the childhood vaccination program is recommended; at the same time, the occurrence of serotype substitution should be taken into account. …”
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Helicobacter pylori: From Bench to Bedside by N Chiba, A Matisko, P Sinclair, ABR Thomson

“…However, the role of H pylori in contributing to nonulcer dyspepsia or nonsteroidal anti-inflammatory drug gastropathy remains controversial. An effective vaccine against H pylori is years away. …”
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Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. …”
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Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells by Kleber Juvenal Silva Farias, Paula Renata Lima Machado, Benedito Antônio Lopes da Fonseca

“…Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. …”
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Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity? by Sin-Yeang Teow, Alif Che Nordin, Syed A. Ali, Alan Soo-Beng Khoo

“…Deeper understanding on how exosomes promote or abate HIV infection can significantly contribute to the development of new and potent antiviral therapeutic strategy and vaccine designs.…”
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A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts by Mustak Ibn Ayub

“…Laboratory research should focus on the bloc mutation to understand its true impacts on the course of the pandemic. Potential drug and vaccine development should also keep the 28881–28883 region of the N protein under consideration.…”
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A New Hope in Immunotherapy for Malignant Gliomas: Adoptive T Cell Transfer Therapy by Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong

“…Although recent clinical results from vaccine strategy for malignant gliomas are encouraging, these trials have some limitations, particularly their failure to expand tumor antigen-specific T cells reproducibly and effectively. …”
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Rotavirus in Calves and Its Zoonotic Importance by Umer Seid Geletu, Munera Ahmednur Usmael, Fufa Dawo Bari

“…So, the primary strategy is to reduce the burden of rotavirus infections by practicing early colostrum’s feeding in newborn calves, using vaccine, and improving livestock management. Rotaviruses have a wide host range, infecting many animal species as well as humans. …”
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Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. This immune response can be enhanced by the application of clinical hyperthermia as evidenced by randomised trial data in patients with melanoma. …”
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The dawn of preventing respiratory syncytial virus lower respiratory tract infections in children by Z Dangor, S A Madhi, H Zar, D Demopoulos

“…Recently, two new RSV prevention strategies have emerged: nirsevimab, a long-acting monoclonal antibody, and a maternal RSV vaccine. Both strategies have shown high efficacy in reducing RSV-LRTI hospitalisation in infants and are being considered for licensure in SA. …”
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Antibiotic Resistance of <i>Staphylococcus aureus</i> Strains—Searching for New Antimicrobial Agents—Review by Michał Michalik, Adrianna Podbielska-Kubera, Agnieszka Dmowska-Koroblewska

“…Researchers’ activities also focus on the potential use of plant extracts, honey, propolis, alkaloids, and essential oils. To date, no vaccine has been approved against <i>S. aureus</i> strains.…”
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Development and Validation of Chlamydia muridarum Mouse Models for Studying Genital Tract Infection Pathogenesis by Yihui Wang, Zixuan Han, Luying Wang, Xin Sun, Qi Tian, Tianyuan Zhang

“…Animal infection models play significant roles in the study of bacterial pathogenic mechanisms and host–pathogen interactions, as well as in evaluating drug and vaccine efficacies. Chlamydia trachomatis is responsible for infections in various mucosal tissues, including the eyes and urogenital, respiratory, and gastrointestinal tracts. …”
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Post-Pandemic Recovery of the Global Economy by E. N. Smirnov

“…In addition, it was found that the world retains a high potential for financial instability, and “vaccine nationalism” is getting worse. The main contradiction is the transboundary nature of the challenges to further economic development with a significant slowdown in global- ization pro-cesses. …”
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