Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities. by Kristina N Delgado, Melissa J Caimano, Isabel C Orbe, Crystal F Vicente, Carson J La Vake, André A Grassmann, M Anthony Moody, Justin D Radolf, Kelly L Hawley

“…The results support the use of ECL-based vaccines and suggest that loop-specific antibodies promote spirochete clearance via Fc receptor-independent as well as Fc receptor-dependent mechanisms.…”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…They have also contributed to groundbreaking discoveries, including the introduction of the first mRNA vaccine (against COVID-19), and have improved certain imaging and diagnostic techniques, too. …”
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A CRISPR-Cas12a-based universal rapid scrub typhus diagnostic method targeting 16S rRNA of Orientia tsutsugamushi. by Bum Ju Park, Sang Taek Heo, Misun Kim, Jeong Rae Yoo, Eun Jin Bae, Su Yeon Kang, Sunghoon Park, Kyeo Re Han, Keun Hwa Lee, Jae Myun Lee, Hyeyoung Lee, Yoon-Jae Song

“…Currently, there is no vaccine for O. tsutsugamushi, and its infection is treated with antibiotics such as doxycycline. …”
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Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions by Lu Yilong, Zhang Xiaoning, Guan Zhiyu, Ji Rui, Peng Fujun, Zhao Chunzhen, Gao Wei, Gao Feng

“…The treatment of cryptosporidiosis is challenging due to the current lack of an effective treatment or vaccine. Ongoing research is focused on understanding the molecular pathogenesis of Cryptosporidium and developing pharmacological treatments. …”
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Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 by Luciana D’Apice, Valerio Costa, Rossella Sartorius, Maria Trovato, Marianna Aprile, Piergiuseppe De Berardinis

“…The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. …”
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Comparison Of Bacillus anthracis Prepared Used Antigens As ‎Diagnostic kit Of Anthrax In Laboratoy Animals.‎ by Al- Jebouri A.J. ‎, Al- Khatib G.M.‎

“…A comparison was carried out among the prepared antigens using skin test in non- vaccinated guinea pigs which showed negative results. …”
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Nontypeable Haemophilus influenzae Otitis Media: Mastoiditis and Meningitis Complicated with Central Venous Thrombosis in an Immunocompetent Child by Erdem Gönüllü, Nesrin Özkan, Ahmet Soysal, Engin Acıoğlu, Emine Betül Tavil, Selin Nar Ötgün, Metin Karaböcüoğlu

“…Implementation of the Haemophilus influenzae type B (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but an increase in nontypeable strain infections. …”
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The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases by Nnamdi Ikemefuna Okafor, Omobolanle Ayoyinka Omoteso, Yahya E. Choonara

“…Abstract Some of the most crucial turning points in the treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with the introduction of antimicrobials and vaccines. Drug resistance and poor effectiveness are key limitations that need to be overcome. …”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Millions of infections every year pose a serious threat to worldwide public health, encouraging scientists to develop a better understanding of the pathophysiology and immune evasion mechanisms of these viruses for vaccine development and antiviral therapy. Extensive research has been conducted in developing effective antivirals for flavivirus. …”
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Passive Protection of Diabetic Rats with Antisera Specific for the Polysaccharide Portion of the Lipopolysaccharide Isolated from Pseudomonas pseudomallei by Larry E Bryan, Sallene Wong, Don E Woods, David AB Dance, W Chaowagul

“…The wide distribution of the polysaccharide antigen among isolates of P pseudomallei used in this study and the protective role of antibody to the conjugated polysaccharide antigen suggest potential as a vaccine.…”
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Optimal control of chikungunya disease: Larvae reduction, treatment and prevention by Djamila Moulay, M. A. Aziz-Alaoui, Hee-Dae Kwon

“…Three main efforts are considered in order to limit the virus transmission. Indeed, there is no vaccine nor specific treatment against chikungunya, that is why the main measures to limit the impact of such epidemic have to be considered. …”
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Mutation analysis of SHP2, SOS1, and SOS2 related to dysregulation of Ras/MAPK pathway in Noonan syndrome by Nihayatul Karimah

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Trafficked Proteins—Druggable in Plasmodium falciparum? by Jasmin Lindner, Kamila Anna Meissner, Isolmar Schettert, Carsten Wrenger

“…Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. …”
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Circulating Dynamics of SARS-CoV-2 Variants between April 2021 and February 2022 in Turkey by Murat Sayan, Ayse Arikan, Murat Isbilen

“…The diagnosis of new variants and monitoring their potential effects on diagnosis, therapeutics, and vaccines by genomic sequencing is essential to manage global public crises. …”
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Applied Comparison of Meta-analysis Techniques by Li Wang, Colin Lewis-Beck, Elyse Fritschel, Erdem Baser, Onur Baser

“…**Results:** All three techniques showed a statistically significant effects from the vaccination. However, once covariates were added, efficacy diminished. …”
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COVID-19 Pandemic in Brunei Darussalam by Wei Shan Ang, Jodi Woan-Fei Law, Vengadesh Letchumanan, Yong Sze Ong, Yatinesh Kumari, Long Chiau Ming, Loh Teng-Hern Tan

“…The key success factors are effective pandemic containment measures, public communication strategy, and enhanced surveillance mechanisms supported by the mass testing program and contact tracing. A national vaccination strategy ensuring adequate vaccine distribution and effective administration has been rolled out to render lasting protection against the infection. …”
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Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection by Christina J. Megli, Sophia M. Carlin, Elizabeth J. Giacobe, Gideon H. Hillebrand, Thomas A. Hooven

“…We conclude by addressing current efforts in vaccine development, underscoring the need for effective prevention strategies against this pervasive pathogen.…”
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B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal by Martyn A. Sharpe, Taylor L. Gist, David S. Baskin

“…The role of thimerosal containing vaccines in the development of autism spectrum disorder (ASD) has been an area of intense debate, as has the presence of mercury dental amalgams and fish ingestion by pregnant mothers. …”
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Hamster and Murine Models of Severe Destructive Lyme Arthritis by Erik Munson, Dean T. Nardelli, Brian K. Du Chateau, Steven M. Callister, Ronald F. Schell

“…However, severe destructive Lyme arthritis can be induced by infecting irradiated hamsters or mice and immunocompetent Borrelia-vaccinated hamsters, mice, and interferon-gamma- (IFN-γ-) deficient mice with viable B. burgdorferi. …”
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Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants by Franklyn Nonso Iheagwam, Solomon Oladapo Rotimi

“…The COVID-19 pandemic, which started in Wuhan, China, has spread rapidly over the world with no known antiviral therapy or vaccine. Interestingly, traditional Chinese medicine helped in flattening the pandemic curve in China. …”
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