Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study by Daya Zhang, Chen Chen, Yunqian Xie, Shuo Zhou, Da Li, Fan Zeng, Shimei Huang, Yanting Lv, Xianfeng Huang, Fengjiao Mao, Jinglei Kuang, Jin Gan, Xiaojing Xu, Shiju Chen, Runxiang Chen, Xiaodong Zhang, Sangni Xu, Minyu Zeng, Haoyue Ren, Feihu Bai

“…Independent risk factors included age over 65, moderate to severe infection, chronic diseases, irregular diet, late sleeping, anxiety, and fewer than 2 vaccinations (p < 0.05). While most individuals infected with COVID-19 fully recover, approximately 12.5% experience intermediate or long-term effects. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Abstract Iron surface determinant B (IsdB), a Staphylococcus aureus (SA) surface protein involved in both heme iron acquisition from host hemoglobin (Hb) and bacterial adhesion, is a proven virulence factor that can be targeted for the design of antibacterial molecules or vaccines. Recent single-molecule experiments on IsdB interaction with cell adhesion factors revealed an increase of the complex lifetime upon applying a stronger force (catch bond); this was suggested to favor host invasion under shear stress. …”
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Sealless Production Ultracentrifuge and Its Magnetically Self-Bearing Openable Motors for Purification in Viral Nanotechnology by Emanuel J. Hubmann, Daniel Steinert, Thomas Nussbaumer, Johann W. Kolar

“…Viral nanotechnology enables new possibilities for gene therapies and vaccines. However, the manufacturing of viral vectors lacks a satisfactory production capable method for purification of full capsids. …”
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Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses by Chukwudi A. Ofodile, Ikemefuna C. Uzochukwu, Fortunatus C. Ezebuo, InnocentMary Ejiofor, Mercy Adebola, Innocent Okpoli, Beatrice Cubitt, Haydar Witwit, Chetachi B. Okwuanaso, Ngozi Onyemelukwe, Juan Carlos de la Torre

“…Lassa fever (LF), a viral hemorrhagic fever disease with a case fatality rate that can be over 20% among hospitalized LF patients, is endemic to many West African countries. Currently, no vaccines or therapies are specifically licensed to prevent or treat LF, hence the significance of developing therapeutics against the mammarenavirus Lassa virus (LASV), the causative agent of LF. …”
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Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 by M. Bastard, D. Falzon, S. Bertagnolio, R. Silva, S.S. Thwin, C. Siquiera Boccolini, J. Rylance, J. Diaz, M. Zignol

“…Caveats for interpretation include changes during the data collection period (viral variation, vaccination coverage) and opportunistic sampling. However, the platform exemplifies how timely, coordinated global reporting can inform our understanding of health emergencies and the vulnerable populations affected.…”
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ANALYSIS OF CHANGES IN AFRICAN SWINE FEVER VIRUS GENETIC STRUCTURE AND BIOLOGICAL PROPERTIES DURING ADAPTATION TO CONTINUOUS CELL CULTURE by Ali Mazloum, N. G. Zinyakov, A. S. Pershin, I. V. Shevchenko, I. Yu. Zhukov, D. N. Fedoseyeva, D. V. Sharypova, A. S. Igolkin, N. N. Vlasova

“…Identifcation of such genes will enable preparation of deletion mutant ASF virus strains as well as development and testing of pilot safe vaccines based on the said virus strains. Comparative analysis of the virus biological characteristics and detection of differences in its genome structure affecting certain phenotypic features is a main method used for the virus basic pathogenicity and immunogenicity examination. …”
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Development of the test kit for detection of SARS-CoV-2 antibodies in sera of susceptible animals by M. A. Volkova, N. G. Zinyakov, P. S. Yaroslavtseva, I. A. Chvala, T. S. Galkina, D. B. Andreychuk

“…The high diagnostic sensitivity and specificity shown by testing of 50 serum samples from minks, foxes, cats and dogs with different immune status, allow us to recommend the developed test kit for screening and monitoring tests and post-vaccination immunity control.…”
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The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case by Rubens Carmo Costa-Filho, Felipe Saddy, João Luiz Ferreira Costa, Leandro Reis Tavares, Hugo Caire Castro Faria Neto

“…Routine incorporation of hMPV testing into clinical protocols could improve the diagnosis and resource use. The development of vaccines, such as the IVX-A12 in phase II trials, offers hope for targeted prevention, underscoring the need for further research and therapeutic innovations.…”
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Optimal control strategies for toxoplasmosis disease transmission dynamics via harmonic mean-type incident rate by Usman Khan, Farhad Ali, Ohud A. Alqasem, Maysaa E. A. Elwahab, Ilyas Khan, Ariana Abdul Rahimzai

“…This study investigates the impact of various optimal control strategies, such as vaccinations for the control of disease and the awareness of disease awareness, on the management of disease.…”
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Investigating the relationship between the immune response and the severity of COVID-19: a large-cohort retrospective study by Riccardo Giuseppe Margiotta, Emanuela Sozio, Fabio Del Ben, Fabio Del Ben, Antonio Paolo Beltrami, Antonio Paolo Beltrami, Daniela Cesselli, Daniela Cesselli, Marco Comar, Alessandra Devito, Martina Fabris, Martina Fabris, Francesco Curcio, Francesco Curcio, Carlo Tascini, Carlo Tascini, Guido Sanguinetti

“…Overall, our study sheds light on the immuno-inflammatory aspects observed in COVID-19 patients prior to vaccination, providing insights for guiding the clinical management of first-time infections by a novel virus.…”
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A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos by Phimpha Paboriboune, Thomas Vial, François Chassagne, Philavanh Sitbounlang, Sengaloun Soundala, Stéphane Bertani, Davone Sengmanothong, Francois-Xavier Babin, Nicolas Steenkeste, Paul Dény, Pascal Pineau, Eric Deharo

“…Public health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of HBV-associated diseases will be overwhelming for Laos in the near future.…”
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Expression of genes of cytokines, transcription factors and differentiation antigens in human dendritic cells activated by double-stranded DNA by A. S. Proskurina, K. E. Orishchenko, E. A. Potter, E. V. Dolgova, A. V. Spaselnikova, G. S. Ritter, N. A. Varaksin, T. G. Ryabicheva, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…One of the most important properties of extracellular double-stranded DNA related to the treatment of various diseases is its ability to activate effector cells of the immune system (anti-tumor and vaccinal immunity) through dendritic cells (DCs). The stimulatory effect of DNA on DCs is mediated by the TLR9 signaling pathway and/or through a system of cytosolic sensors and is manifested by increased expression of MHC class II antigens and costimulatory molecules and by increased synthesis of immunoregulatory cytokines. …”
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Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 M^pro by Jiayi Ren, Zhengfu Zhang, Yi Xia, Daqun Zhao, Dingqin Li, Shujun Zhang

“…There is an urgent need to identify a relatively stable target for the development of universal vaccines and drugs that can effectively combat both SARS-CoV-2 strains and their mutants. …”
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Loss-of-function variant in MAGT1 leading to XMEN disease in a Colombian patient with a common variable immunodeficiency by Sebastián Gutiérrez-Hincapié, Julio César Orrego, José Luis Franco, Claudia M. Trujillo-Vargas

“…Common variable immunodeficiency is a diagnosis of exclusion in immunodeficient patients with increased susceptibility to infections, hypogammaglobulinemia, deficient response to vaccination, or low percentages of switched memory B cells. …”
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Simple and Fail-safe Method to Transform Miniprep Escherichia coli Strain K12 Plasmid DNA Into Viable Agrobacterium tumefaciens EHA105 Cells for Plant Genetic Transformation by Beenzu Siamalube, Emmanuel Ehinmitan, Maina Ngotho, Justus Onguso, Steven Runo

“…Plants are genetically engineered to develop disease-free varieties, knock out unsettling traits for crop improvement, or incorporate an antigenic protein to make the plant a green factory for edible vaccines. The method’s robustness was validated through successful transformations, demonstrating its effectiveness as a standard approach for researchers working in plant biotechnology. …”
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FeLV-induced feline leukemia as a natural model for leukemia pathophysiology study (review) by T. V. Tabakaeva, A. V. Tsybulsky, K. A. Baranchugova, I. V. Galkina, M. Yu. Shchelkanov

“…Immunomodulators and chemotherapy are alsoused. Vaccination isusedas apreventive measure, but commercially available adjuvanted and non-adjuvanted vaccinesdo not confer effective protection from the infection. …”
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Serosurvey of Bovine Viral Diarrhea Virus in Cattle in Southern Japan and Estimation of Its Transmissibility by Transient Infection in Nonvaccinated Cattle by Norikazu Isoda, Satoshi Sekiguchi, Chika Ryu, Kosuke Notsu, Maya Kobayashi, Karin Hamaguchi, Takahiro Hiono, Yuichi Ushitani, Yoshihiro Sakoda

“…Neutralizing antibodies against BVDV-1 and BVDV-2 were detected more frequently in 18 vaccinated farms than in 17 nonvaccinated farms. In the nonvaccinated farms, 9.6%, 1.8%, and 13.8% of the cattle were estimated to have a history of infection with BVDV-1, BVDV-2, and both, respectively. …”
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Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus by Jinghang Zhou, Yuqi Duan, Menglan Liu, Jinyang Liu, Zenglei Hu, Zhiqiang Duan

“…This review aims to enhance our understanding of the complex functions of polymerase-associated proteins in NDV replication and pathogenesis and to contribute to the development of more effective vaccines and antiviral drugs against NDV challenges.…”
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Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation Thresholds In Vivo by Thorsten Peters, Wilhelm Bloch, Oliver Pabst, Claudia Wickenhauser, Claudia Uthoff-Hachenberg, Susanne V. Schmidt, Georg Varga, Stephan Grabbe, Daniel Kess, Tsvetelina Oreshkova, Anca Sindrilaru, Klaus Addicks, Reinhold Förster, Werner Müller, Karin Scharffetter-Kochanek

“…Our findings may stimulate further studies on a modification of vaccination strategies using highly haptenated antigens in individuals suffering from LAD1.…”
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Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months by Brenda Asiimwe-Kateera, Nienke Veldhuijzen, Jean Paul Balinda, John Rusine, Sally Eagle, Joseph Vyankandondera, Julie Mugabekazi, Pascale Ondoa, Kimberly Boer, Anita Asiimwe, Joep Lange, Peter Reiss, Janneke van de Wijgert

“…We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.…”
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