Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…Shuhan Liu,1– 3 Haisong Li,4 Shiwen Xi,1,2 Yuning Zhang,1,2,* Tianmeng Sun1,2,5,6,* 1Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, People’s Republic of China; 3Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 5International Center of Future Science, Jilin University, Changchun, People’s Republic of China; 6State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianmeng Sun; Yuning Zhang, The First Hospital of Jilin University, 71 Xinmin St, Changchun, Jilin, People’s Republic of China, Email tsun41@jlu.edu.cn; zhangyuning@jlu.edu.cnAbstract: Given the complexity of the central nervous system (CNS) and the diversity of neurological conditions, the increasing prevalence of neurological disorders poses a significant challenge to modern medicine. …”
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WALLABY Pilot Survey: Star Formation Enhancement and Suppression in Gas-rich Galaxy Pairs by Qifeng Huang, Jing Wang, Xuchen Lin, Se-Heon Oh, Xinkai Chen, B. Catinella, N. Deg, H. Dénes, B. -Q. For, B. S. Koribalski, K. Lee-Waddell, J. Rhee, A. X. Shen, Li Shao, K. Spekkens, L. Staveley-Smith, T. Westmeier, O. I. Wong, A. Bosma

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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…JiangFei Zhou,1,* SongSong Jiao,1,* Jian Huang,2,* TianMing Dai,3,* YangYang Xu,1,* Dong Xia,4,* ZhenCheng Feng,1 JunJie Chen,1 ZhiWu Li,5 LiQiong Hu,4 QingQi Meng1,3 1Department of Orthopedics, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 4Critical Care Medicine Department, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 5Department of Orthopedics, the 2nd People’s Hospital of Bijie, Guizhou, 551700, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiQiong Hu; QingQi Meng, Email 13929526981@163.com; mengqingqi@jnu.edu.cnBackground: Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. …”
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Association between Corneal Stiffness Parameter at the First Applanation and Keratoconus Severity by Kaili Yang, Liyan Xu, Qi Fan, Shengwei Ren

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Solar Coronal Mass Ejection and Post–Coronal Mass Ejection Blob Formation in Two-fluid Simulations by J. C. Du, Z. W. Ma

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Galaxies Lighting Up: Discovery of Seventy New Turn-on Changing-look Active Galactic Nuclei by Qian Yang, Paul J. Green, Xue-Bing Wu, Michael Eracleous, Linhua Jiang, Yuming Fu

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Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment by Deng Y, Fu T, Gao D, Zhou J, Nie X, Wang F, Yu Q

“…Yu’en Deng,1,2 Ting Fu,1 Dian Gao,3 Jianming Zhou,1 Xinhua Nie,1 Fenfen Wang,1 Qiongfang Yu1 1Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Huankui Academy, Jiangxi Medical College, Nanchang University, Nanchang, 330031, People’s Republic of China; 3Department of Pathogen Biology and Immunology, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: Qiongfang Yu, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Minde Road 1, Nanchang, 330006, People’s Republic of China, Email qiongfangyu@yeah.netPurpose: Crohn’s disease (CD) is a chronic inflammatory disorder with periods of exacerbation and remission. …”
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Implementing Cancer Pain Management Training for Pharmacists Using the Kirkpatrick Evaluation Model by Liu Y, Peng Y, Zhu B, Xia Z, Yuan Y, Zhang F

“…Yu Liu,1 Yang Peng,2 Bimin Zhu,2 Zhihua Xia,1 Yonghua Yuan,3 Fujun Zhang4 1Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Pharmacy, Dianjiang County People’s Hospital, Chongqing, 408300, People’s Republic of China; 3College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 4Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Fujun Zhang, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email cnzfj@cqmu.edu.cnPurpose: To develop a training program on cancer pain management for pharmacists and to evaluate the effectiveness of the training.Methods: The program developed a well-structured curriculum and subsequent evaluation of training effectiveness, guided by the Kirkpatrick four-tier evaluation model, including reaction, learning, behavior, and results. …”
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The Age–Velocity Dispersion Relations of the Galactic Disk as Revealed by the LAMOST-Gaia Red Clump Stars by Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu

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RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…Yuting Qin,1,* Shuanglin Liao,1,* Jianbo Sun,2 Huiyun Ye,1 Jiafu Li,1 Jiahui Pan,1 Junbing He,3 Zhengyuan Xia,4,5 Yiming Shao1,6 1Dongguan Key Laboratory of Sepsis Translational Medicine, The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 2Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 3The Key Laboratory of Organ Dysfunction and Protection Translational Medicine, Jieyang Medical Research Center, Jieyang People’s Hospital, Jieyang, Guangdong, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China; 5State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6The Key Laboratory of Sepsis Translational Medicine, Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiming Shao, Dongguan Key Laboratory of Sepsis Translational Medicine, the Intensive Care Unit,The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, Guangdong Province, 523710, People’s Republic of China, Tel +86 18826690188, Email sym@gdmu.edu.cn Zhengyuan Xia, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China, Tel +852-68798794, Email zyxia@hku.hkAbstract: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways and plays critical roles in septic inflammatory storms and vascular endothelial dysfunction. …”
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The Influence of General Relativity on the Spins of Celestial Bodies in Inclined Orbits by Huan-Rong Yuan, Ying Wang, Xin Wu, Ji-Wei Xie, Hui-Gen Liu, Ji-Lin Zhou, Wei Sun

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Effects of permafrost stability changes on vegetation dynamics in the middle part of the Greater Khingan Mountains by Jiaman Sun, Wei Shan, Chengcheng Zhang

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Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment by Jiang H

“…Hua Jiang Department of Urology, Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), Zhuhai, People’s Republic of ChinaCorrespondence: Hua Jiang, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), No. 1439, Zhufeng Road, Zhuhai, 519100, People’s Republic of China, Tel +8613726205880, Email jianghua426@zmu.edu.cnAbstract: Prostate cancer is prevalent among men aged 65 and older. …”
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In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing by Li J, Meng H, Guo W, Zhou L, Wu S, Gao G, Liu Q, You D, Qu W

“…Jianwen Li,1,2,* Hongqi Meng,3,* Wenlai Guo,3 Lubin Zhou,4 Siyu Wu,3 Guanghui Gao,4 Quanzhe Liu,3 Di You,5 Wenrui Qu2,3 1Gastroenteric Medicine and Digestive Endoscopy Center, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 2Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, Changchun, 130041, People’s Republic of China; 3Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 4Polymeric and Soft Materials Laboratory, Advanced Institute of Materials Science, School of Chemical Engineering, Changchun University of Technology, Changchun, 130012, People’s Republic of China; 5Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, 130012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Di You; Guanghui Gao, Email youdi1118@jlu.edu.cn; ghgao@ccut.edu.cnBackground: Diabetic foot ulcers (DFUs) are often associated with persistent inflammatory response, impaired macrophage polarization, and slow vascular regeneration. …”
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Family Function and Self-Management of Patients With Early Chronic Kidney Disease: The Mediating Roles of Self-Perceived Burden and Ego Depletion by Cui Y, Liu N, Guo Z, Liu Q, Zhang M, Li J, Mu H, Zhang Y, Chen X

“…Yi Cui,1 Na Liu,1 Zhihua Guo,2 Qin Liu,1 Man Zhang,3 Jiayao Li,1 Hezi Mu,4 Yinling Zhang,1,* Xia Chen5,* 1Department of Nursing, Air Force Medical University, Xi’an, People’s Republic of China; 2Department of Military Medical Psychology, Air Force Medical University, Xi’an, People’s Republic of China; 3Department of Nursing, Shaanxi Provincial People’s Hospital, Xi’an, People’s Republic of China; 4Department of Orthopedics, The Second Affiliated Hospital of Air Force Medical University, Xi’an, People’s Republic of China; 5Department of Nursing, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinling Zhang, Department of Nursing, Air Force Medical University, Xi’an, 710000, People’s Republic of China, Email zyl-ylz@163.com Xia Chen, Department of Nursing, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China, Email 1328219974@qq.comBackground: Effective self-management in the early stage of chronic kidney disease (CKD) is key to delaying disease progression. …”
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Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…Cunte Chen,1,2,* Kangjie Qiu,2,* Jie Chen,3,* Shunqing Wang,1 Yuping Zhang,1 Caixia Wang,1 Yangqiu Li2 1Department of Hematology, Guangzhou First People’s Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, 510180, People’s Republic of China; 2Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, People’s Republic of China; 3Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yangqiu Li, Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, People’s Republic of China, Email yangqiuli@hotmail.com Caixia Wang, Department of Hematology, Guangzhou First People’s Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, 510180, People’s Republic of China, Email wangcx225@163.comPurpose: Our previous study has demonstrated that high expression of immune checkpoints (ICs) was significantly associated with adverse clinical outcomes in patients with acute myeloid leukemia (AML). …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Yajuan Yan,1,* Ting Duan,1,* Xiaonan Xue,1,* Xiaojuan Yang,2 Miao Liu,2 Bin Ma,3,4 Xiangguo Duan,2 Chunxia Su1 1Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Inspection, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 3Department of Surgery, The First People’s Hospital of Yinchuan, Yinchuan, Ningxia, People’s Republic of China; 4The Second School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunxia Su; Xiangguo Duan, Email chunxiasu@qq.com; duanxiangguo@nxmu.edu.cnBackground: Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. …”
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Comparison of Nasopharyngeal Airway with Endoscopic Respiratory Mask for Hypoxemia in Painless Gastrointestinal Endoscopy in Obese Outpatients: Study Protocol for a Randomized Cont... by Xiang D, Deng L, Zhou R, Zhang X, Tian L, Jiang W, Zhou Y, Chen W, Peng Y

“…Dongmei Xiang,1,* Lei Deng,2,* Rui Zhou,3– 5 Xianjie Zhang,1 Lei Tian,1 Wencai Jiang,1 Yukai Zhou,1 Wenya Chen,1 Yanhua Peng1 1Department of Anesthesiology, the Deyang People’s Hospital, Deyang City, Sichuan Province, 618000, People’s Republic of China; 2Department of Gastroenterology, the Deyang People’s Hospital, Deyang City, Sichuan Province, 618000, People’s Republic of China; 3Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 4Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 5Clinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, 200434, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanhua Peng, Department of Anesthesiology, the Deyang People’s Hospital, No. 173 section 1 Mount Taishan North Road Jingyang District, Deyang City, Sichuan Province, People’s Republic of China, Email pyhuaa@163.comIntroduction: Sedatives and anesthetics can modify airway tone and induce respiratory depression, exacerbating the gas exchange impairments associated with obesity. …”
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Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciproc... by Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng

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Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro by Han T, Jia T, Wang J

“…Tala Han,1 Ting Jia,1 Junrui Wang1,2 1Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of China; 2Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, The Affiliated Hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of ChinaCorrespondence: Junrui Wang, Clinical Laboratory, Affiliated hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of China, Tel +86 04713451315, Email wangjunrui123@yeah.netBackground: Linezolid resistance in methicillin-resistant Staphylococcus aureus (MRSA) was reported frequently in recent years, but the mechanism underlying this process was less reported, especially for clinical isolates with different genetic background. …”
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