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Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study
Published 2025-01-01“…Gaia Zucca,1 Barbara Vigani,1 Caterina Valentino,1 Marco Ruggeri,1 Nicoletta Marchesi,1 Alessia Pascale,1 Giulia Giovilli,2 Lorenzo Malavasi,2 Giuseppina Sandri,1 Silvia Rossi1 1Department of Drug Sciences, University of Pavia, Pavia, 27100, Italy; 2Department of Chemistry and INSTM, University of Pavia, Pavia, 27100, ItalyCorrespondence: Silvia Rossi; Barbara Vigani, Department of Drug Sciences, University of Pavia, Via Taramelli 12, Pavia, 27100, Italy, Email silvia.rossi@unipv.it; barbara.vigani@unipv.itPurpose: The main purpose of the study was the formulation development of nanogels (NHs) composed of chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as a potential treatment for early-stage diabetic retinopathy.Methods: Different formulations of NHs were prepared by varying polymer concentration, lCH ratio, and pH and, then, characterized for particle size, zeta potential, particle concentration (particles/mL) and morphology. …”
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