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198781
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198783
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198784
UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research
Published 2025-01-01“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
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198785
Propagation of Interplanetary Shocks in the Inner Heliosphere
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198786
Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients
Published 2012-01-01Get full text
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198787
Asymmetric ion transport through heterogeneous bilayers of covalent organic frameworks
Published 2025-01-01“…Notably, this ionic current rectification property could be modulated by the salt concentration and the structural composition of the membrane, and it was universal for various COF heterojunctions with different chemical ingredients. …”
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198788
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198789
Dual-stream disentangled model for microvascular extraction in five datasets from multiple OCTA instruments
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198790
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198791
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198792
655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations
Published 2007-01-01Get full text
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198793
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198794
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198795
Detection of Invasive Species (Siam Weed) Using Drone-Based Imaging and YOLO Deep Learning Model
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198796
Diagnosis and treatment of descending optic neuritis developed as a manifestation of local viral encephalitis (a clinical case)
Published 2022-11-01“…Ulianov Chuvash State University, Cheboksary, Russian Federation </p> <p> <sup>2</sup>Cheboksary Branch of the S. …”
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198797
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198798
In vitro study of resveratrol as an antioxidant for boar semen preservation: A systematic review
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198799
Impact of training dairy farm personnel on milking routine compliance, udder health, and milk quality
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198800