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  1. 198781
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  4. 198784

    UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

    Published 2025-01-01
    “…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
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  5. 198785
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  7. 198787

    Asymmetric ion transport through heterogeneous bilayers of covalent organic frameworks by Xiaopeng Zhang, Shixian Xin, Qin Qian, Xiaoyi Xi, Munan Fang, Zhifei Sun, Yunyang Wang, Yulong Li, Yue Wang, Xingtao Tian, Yuntong Li, Siyu Wang, Jinlei Yang, Zhiyong Tang, Lianshan Li

    Published 2025-01-01
    “…Notably, this ionic current rectification property could be modulated by the salt concentration and the structural composition of the membrane, and it was universal for various COF heterojunctions with different chemical ingredients. …”
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  8. 198788
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  15. 198795
  16. 198796

    Diagnosis and treatment of descending optic neuritis developed as a manifestation of local viral encephalitis (a clinical case) by N.V. Korsakova, E.I. Korsakova

    Published 2022-11-01
    “…Ulianov Chuvash State University, Cheboksary, Russian Federation </p> <p> <sup>2</sup>Cheboksary Branch of the S. …”
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  17. 198797
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