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    Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

    Published 2025-02-01
    “…Xuanlin Wu, Tao Pan, Zhihao Fang, Titi Hui, Xiaoxiao Yu, Changxu Liu, Zihao Guo, Chang Liu Department of General Surgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of ChinaCorrespondence: Chang Liu, Department of General Surgery, Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang District, Harbin, Heilongjiang, 150001, People’s Republic of China, Tel +86-13313699697, Email lc19726666@163.comBackground: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), as a common chronic liver condition globally, is experiencing an increasing incidence rate which poses significant health risks. …”
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    Pharmacokinetics and Bioequivalence of Two Fixed-Dose Combination Tablets of Valsartan/Amlodipine (80/5 Mg) in Healthy Chinese Subjects by Tian M, Huang J, Chen Y, Jin Q, Jiang H, Shi C, Mei J, Xu M, Yu X, Yang S

    Published 2025-01-01
    “…Mengli Tian,1 Jinlong Huang,2 Yingrong Chen,1 Qiuyue Jin,1 Hong Jiang,2 Cunyuan Shi,2 Jue Mei,1 Min Xu,1 Xiang Yu,1 Shuixin Yang1 1Clinical Trial Center, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, 313000, People’s Republic of China; 2Zhejiang Jianfeng Pharmaceutical Co Ltd., Jinhua, 321025, People’s Republic of ChinaCorrespondence: Shuixin Yang, Clinical Trial Center, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, 1558, North Third Ring Road, Huzhou, 313000, People’s Republic of China, Tel +86-0572-2978254, Email ysx@hzhospital.comPurpose: The study aimed to investigate the pharmacokinetics and bioequivalence of coformulations of valsartan and amlodipine in healthy Chinese subjects under both fasting and fed conditions.Methods: The research was conducted under both fasting and fed studies and employed a single-center, randomized, open-label, single-dose, three-period design with partial-repeat and crossover elements. …”
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