The role of tribbles homolog 2 in cell proliferation by Wenkang Zhang, Mingkang Li, Minhao Zhang, Gaoliang Yan, Chengchun Tang

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DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer by Zhi-Zhi Yang, Bing Yang, Haiyan Yan, Xingyu Ma, Bin Tian, Bingqi Zheng, Yong-Xian Chen, Yi-Ming Dong, Jinsi Deng, Ziling Zhan, Yanmei Shi, Jing Yuan Zhang, Daning Lu, Jie-Hua He, Yin Zhang, KaiShun Hu, Shuang Zhu, Keda Zhou, Yu-Chan Zhang, Yiqing Zheng, Dong Yin, Jian-You Liao

“…Mechanistically, DCAF13 promotes Pol I transcription activity by facilitating the K63-linked ubiquitination of RPA194. This process stimulates global protein synthesis and cell growth. …”
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Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity by Jun-Zhou Li, Yi-Lin Gu, Wei Zhang, Shen Cong, Ruo-Na Wang, Yi-Nan Ma, Ya Jin, Hai-Lei Wei

“…HrpH suppresses salicylic acid (SA) signaling and interacts with the E3 ubiquitin ligase ATL2 via its SLT domain, independent of its catalytic glutamate. …”
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hUC-MSC extracellular vesicles protect against hypoxic-ischemic brain injury by promoting NLRP3 ubiquitination by Shanshan Xiao, Ying Lv, Xuejing Hou, Shuqiang Qu

“…These effects were linked to the inhibition of NLRP3 inflammasome activation and enhanced ubiquitination via the protein kinase A (PKA) pathway. …”
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tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination by Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu

“…Mechanistically, tRF-AspGTC binds to galectin-3, inhibiting tripartite motif 29-mediated ubiquitination and stabilizing galectin-3. This stabilization activates the toll-like receptor 4/MyD88/nuclear factor kappa B pathway, further driving phenotypic switching and inflammation. …”
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The E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia by Clément Larrue, Sarah Mouche, Jerome Tamburini

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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo by Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis

“…In this study, we used Caenorhabditis elegans to screen for E3 ubiquitin ligases regulating the activity of TFEB’s homolog, HLH-30, upon pathogenic infection. …”
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Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein. by Qian Qiu, Zihan He, Jing Liu, Huijun Xu, Jinyu Wang, Nannan Liu, Ning Kang, Shaokun Pan, Weien Yu, Zixiang Gao, Shimei Zhang, Yang Yang, Qiang Deng, Youhua Xie, Jiming Zhang, Zhongliang Shen

“…Mechanistically, MSX1 induces ubiquitin-independent proteasomal degradation of HBx, which is mediated through HBx C-terminal domain. …”
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Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins by Juliana Cristina Tobar da Silva, Mariângela Rangel Alves Nogueira, Yara Martins da Silva, Fábio César Sousa Nogueira, Nathalie Henriques Silva Canedo, Katia Carneiro, Denise de Abreu Pereira

“…Quantitative analysis identified significant changes in proteins associated with sarcomere organization and protein ubiquitination, such as myomesin, myozenin, and E3 ubiquitin-protein ligase rififylin, suggesting these as potential therapeutic targets.…”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…We confirmed ACTL6A as a novel downstream target for FBXW7. The in vivo ubiquitination assay showed that FBXW7 repressed HCC malignancy by regulating the oncogenic activity of ACTL6A in a ubiquitin-dependent manner. …”
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E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury by Qin Zhang, Hai‐Jin Huang, Jing‐Ling Zhang, Ying Tian, Ying Hu

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March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation by Osama A. Kishta, Antoine Sabourin, Leora Simon, Toby McGovern, Maxime Raymond, Tristan Galbas, Abdelilah Majdoubi, Satoshi Ishido, James G. Martin, Jacques Thibodeau

“…Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. …”
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Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

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Pan-Cancer Analyses of the Tumor Microenvironment Reveal That Ubiquitin-Conjugating Enzyme E2C Might Be a Potential Immunotherapy Target by Guang-zhao Huang, Ze-qun Chen, Juan Wu, Ting-ru Shao, Chen Zou, Yi-long Ai, Xiao-zhi Lv

“…Increasing evidence indicated that the tumor microenvironment (TME) played a crucial role in cancer initiation and progression. Ubiquitin-conjugating enzyme E2C (UBE2C) was differentially expressed in many cancer types. …”
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WAC Facilitates Mitophagy‐mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination‐Dependent Degradation by Shuai Fan, Jinteng Li, Guan Zheng, Ziyue Ma, Xiaoshuai Peng, Zhongyu Xie, Wenjie Liu, Wenhui Yu, Jiajie Lin, Zepeng Su, Peitao Xu, Peng Wang, Yanfeng Wu, Huiyong Shen, Guiwen Ye

“…Interestingly, WAC interacts with the TM domains of PINK1 and prevents the K137 site from ubiquitination modification. The study elucidates the mechanism by which WAC modulates MSC osteogenesis, binds to PINK1 to protect it from ubiquitination, and identifies potential therapeutic targets for osteoporosis and bone defect repair.…”
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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination by Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja-Katrin Bielinsky

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Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control by Christina Schmidt, Kunjan Harit, Stephan Traidl, Michael Naumann, Thomas Werfel, Thomas Werfel, Lennart M. Roesner, Lennart M. Roesner, Gopala Nishanth, Dirk Schlüter, Dirk Schlüter

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Trim13‐induced ubiquitination of RPS27A inhibits the progression of lung cancer by depending on the inactivation of NF‐κB signaling pathway by Lailing Li, Hui Zhou, Yayun Cui, Ke Xu

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Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…Curcumin reduces ubiquitination, inflammation in skeletal muscle by regulating the NF-KB/UPS axis and improves muscle malignant metabolic phenotype and mitochondrial dysfunction, to alleviate muscle atrophy and loss of function in mice with breast cancer cachexia.…”
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Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway by Tang Nannan, Li Jiatong, Wang Zhuo, Zuo Jinlu, Zhang Zifeng, Huang Di, Han Yannan, Chen Yuqing, Sun Yilin, Li Xiang, Mu Ruxue, Ma Qingxue, Zhang Jie, Wu Jiaying, Wang He, Zhao Hongxia, Dong Xingli, Wang Zhiguo, Liu Yu, Zhao Dan, Yang Baofeng

“…Small ubiquitin-like modifiers (SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer, diabetes, heart failure, and neurological diseases. …”
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