Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities by Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan

Subjects: “…ubiquitination…”
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E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration by Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu

“…Ubiquitin protein ligase E3 is the most critical molecule in the UPS system. …”
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Research progress on the antiviral immune regulation of ubiquitin ligase F-box family by MENG Xiangbo, LI Tianqi, ZHANG Tong

Subjects: “…f-box protein|scf complex|ubiquitin-protein ligases|antiviral|ubiquitination|natural immunity|immune evasion|interferons…”
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Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro by Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

“…In this study, the effects of single immunoglobin IL-1 receptor-related protein (SIGIRR) on tumor necrosis factor- (TNF-) receptor-associated factor 6 (TRAF6) ubiquitination in acute lung injury (ALI) were evaluated in both alveolar epithelial cells and alveolar macrophage cells in vitro. …”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

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Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. by Shuang Li, Yongbin Chen, Qing Shi, Tao Yue, Bing Wang, Jin Jiang

“…Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that Hh increases Smo cell surface expression by inhibiting its ubiquitination. …”
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A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma by Xiuyun Chen, SenLin Li, Lixue Cao, Shaoxian Chen, Qiuxiong Lin, Shilong Zhong

Subjects: “…Ubiquitin…”
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NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets by Heng Wu, Junhui Zuo, Yu Dai, Hairui Li, Song Wang

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A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation. by Wenjia Yu, Meng Li, Wenjun Wang, Haiyan Zhuang, Jiamin Luo, Yuying Sang, Cecile Segonzac, Alberto P Macho

“…Moreover, RipE1 associates with plant ubiquitin proteases, which contribute to RipE1 deubiquitination and stabilization. …”
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Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer by Athina Stravodimou, Gianluigi Mazzoccoli, Ioannis A. Voutsadakis

“…Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS). This paper will examine PPARγ in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.…”
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The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis. by Qiuling Li, Kayla Y Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua Martinez, Dion Dickman, Nicholas Stavropoulos

“…Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. …”
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Effect of ubiquitin-specific proteinase 43 on ovarian serous adenocarcinoma and its clinical significance by Qin Li, Wenhao Li, Jiahao Wang, Wenjing Shi, Taorong Wang

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Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…Using genetic code expansion and incorporation of commercially available unnatural amino acids, we have developed a highly accessible method whereby interactions between biotinylated ubiquitin-like protein (UBL) probes and their binding partners can be stabilised using ultraviolet (UV) light-induced crosslinks. …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…Mechanically, DES induced PPAR-γ ubiquitination and degradation in protein level, which can be totally reversed by PIO. …”
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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). …”
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The Role of the Cullin-5 E3 Ubiquitin Ligase in the Regulation of Insulin Receptor Substrate-1 by Christine Zhiwen Hu, Jaswinder K. Sethi, Thilo Hagen

“…IRS1 has been reported to be a substrate for ubiquitin-dependent proteasomal degradation. Given that SOCS proteins can function as substrate receptor subunits of Cullin-5 E3 ubiquitin ligases, we examined whether Cullin-5 dependent ubiquitination is involved in the regulation of basal IRS1 protein stability and signal-induced IRS1 degradation. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…Background. Ubiquitin-related proteins have garnered increasing attention for their roles in tumorigenesis. …”
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The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity by Yujia Li, Max Xuezhong Ma, Bo Qin, Liang-Tzung Lin, Christopher D. Richardson, Jordan Feld, Ian D. McGilvray, Limin Chen

“…Background and Aims. Ubiquitin-specific protease 18 (USP18) is involved in immunoregulation and response to interferon- (IFN-) based treatment in patients chronically infected with hepatitis C virus (HCV). …”
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TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis by Xinxing Wang, Mingze Ma, Shuai Shao, Xianwen Xu, Chuan Qin, Ruxin Gao, Zhenhai Zhang

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ASB1 engages with ELOB to facilitate SQOR ubiquitination and H2S homeostasis during spermiogenesis by Jinxing Lv, Tiantian Wu, Jiajia Xue, Cong Shen, Wenxin Gao, Xia Chen, Yueshuai Guo, Mingxi Liu, Jun Yu, Xiaoyan Huang, Bo Zheng

“…In this study, we demonstrate that ASB1, the substrate recognition subunit of a ubiquitin ligase, is highly expressed in the mouse testis. …”
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