Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

“…Using baseline data from a longitudinal study, we aimed to determine factors associated with sphincter tone and the accuracy of sphincter tonality to detect persons engaging in receptive anal intercourse.Methods Clinicians in Chicago, Houston and Milwaukee, USA conducted digital anal rectal examinations (DARE) to score sphincter resting tone (RT) and squeeze tone (ST). …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

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The prevalence of malaria in the five districts of Limpopo Province, South Africa, 2015 - 2017 by M T Lamola, A Musekiwa, A de Voux, C Reddy, M Morifi, P C Mutevedzi

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Monster Radio Jet (>66 kpc) Observed in Quasar at z ∼​​​​​ 5 by Anniek J. Gloudemans, Frits Sweijen, Leah K. Morabito, Emanuele Paolo Farina, Kenneth J. Duncan, Yuichi Harikane, Huub J. A. Röttgering, Aayush Saxena, Jan-Torge Schindler

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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

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MAMMOTH-Subaru. II. Diverse Populations of Circumgalactic Lyα Nebulae at Cosmic Noon by Mingyu Li, Haibin Zhang, Zheng Cai, Yongming Liang, Nobunari Kashikawa, Ke Ma, Xiaohui Fan, J. Xavier Prochaska, Bjorn H. C. Emonts, Xin Wang, Yunjing Wu, Shiwu Zhang, Qiong Li, Sean D. Johnson, Minghao Yue, Fabrizio Arrigoni Battaia, Sebastiano Cantalupo, Joseph F. Hennawi, Satoshi Kikuta, Yuanhang Ning, Masami Ouchi, Rhythm Shimakawa, Ben Wang, Weichen Wang, Zheng Zheng, Zhen-Ya Zheng

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Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases by Seyyed Ali Hosseini, Stijn Servaes, Brandon Hall, Sourav Bhaduri, Archith Rajan, Pedro Rosa-Neto, Steven Brem, Laurie A. Loevner, Suyash Mohan, Sanjeev Chawla

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Structural Vulnerability Factors and Gestational Weight Gain:  A Scoping Review on the Extent, Range, and Nature of the Literature by Labonté, Jocelyne M, Dumas, Alex, Clark, Emily, Savard, Claudia, Fournier, Karine, O’Connor, Sarah, Morisset, Anne-Sophie, Fontaine-Bisson, Bénédicte

“…Studies spanned 22 high-income countries, were predominantly conducted in the USA (77%), and most studies (60%) had a retrospective design. …”
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Men’s Attitudes Towards Participation in Organised Prostate Cancer Testing: An Abductive Thematic Analysis by Markus Arvendell, Lottie Phillips, Sara Delilovic, Moa Backman Enelius, Karin Olsson, Anetta Bolejko, Olof Akre, Sigrid Carlsson, Anne Richter, Anna Lantz

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A preliminary study of linear accelerator-based spatially fractionated radiotherapy by Young Kyu Lee, Yunji Seol, Byeong Jin Kim, Kyu Hye Choi, Ji Hyun Hong, Chan-beom Park, Sun Hwa Kim, Hyeong Wook Park, Wonjoong Cheon, Young Nam Kang, Byung‑Ock Choi

“…The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.MethodsA cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.0 treatment planning system (Varian, Palo Alto, USA). The plans were optimized employing a 3 × 3 × 3 lattice structure with vertex diameters ranging from 0.5 to 2.0 cm and separations from 1.0 to 5.0 cm. …”
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Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift by Erica Grasso, Francesco Certo, Mario Ganau, Giulio Bonomo, Giuseppa Fiumanò, Giovanni Buscema, Andrea Maugeri, Antonella Agodi, Giuseppe M. V. Barbagallo

“…Pre-operative MRI was elastically fused with an intraoperative CT scan (BodyTom; Samsung-Neurologica, Danvers, MA, USA) acquired at the end of the resection. Diagnostic specificity and the sensitivity of each tool was determined. …”
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Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments by Elizaveta Vinogradova, Zharkyn Jarmukhanov, Madiyar Nurgaziyev, Alibek Kossumov, Ayaulym Nurgozhina, Nurislam Mukhanbetzhanov, Shynggys Sergazy, Laura Chulenabyeva, Argul Issilbayeva, Sholpan Askarova, Aiym Kaiyrlykyzy, Saule Rakhimova, Ulan Kozhamkulov, Ulykbek Kairov, Zhanagul Khassenbekova, Dinar Tarzhanova, Ainur Akilzhanova, Joseph H. Lee, Joseph Terwilliger, Aliya Sailybayeva, Makhabbat Bekbossynova, Zhaxybay Zhumadilov, Samat Kozhakhmetov, Almagul Kushugulova

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Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D by Lihua Wang, Siyu Wang, Jason A. Anema, Vaha A. Moghaddam, Yanli Lu, Shiow Lin, E. Warwick Daw, Allison L. Kuipers, Iva Miljkovic, Michael Brent, Gary J. Patti, Bharat Thygarajan, Joseph M. Zmuda, Michael A. Province, Ping An

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Social determinants and follow-up care after emergency department discharge for traumatic intracranial hemorrhage by Meghan M. Dillan, Joseph Piktel, Adam Perzynski, Mary Jo Roach, Kristen K. Curtis, Yasir Tarabichi, Lance Wilson, Michael L. Kelly

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Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial by Yu Wang, Xiao Wang, Ying Lin, Chao-Qun Yan, Guang-Xia Shi, Cun-Zhi Liu, Jing-Wen Yang, Jian-Feng Tu, Shi-Yan Yan, Xin-Tong Su, Li-Qiong Wang, Si-Bo Kang, Bao-Hong Mi, He-Wen Li, Xue-Zhou Wang

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Sexual Practices and HIV Prevention Strategies Used by Female Sex Workers in Lagos, Nigeria: An Assessment of the Willingness to Use a Microbicide by Ekama SO, Sheth AN, Ilomuanya MO, Okwuzu JO, Musa AZ, Idigbe I, Ezeobi PM, Oladele DA, Ezechi OC, Salako BL

“…Sabdat Ozichu Ekama,1 Anandi N Sheth,2 Margaret O Ilomuanya,3 Jane Ogoamaka Okwuzu,1 Adesola Zaidat Musa,1 Ifeoma Idigbe,1 Paschal Mbanefo Ezeobi,1 David Ayoola Oladele,1 Oliver Chukwujekwu Ezechi,1 Babatunde Lawal Salako1 1Clinical Sciences Department, Nigerian Institute of Medical Research, Yaba, Lagos, P.M.B 2013, Nigeria; 2Department of Medicine, Division of Infectious Diseases, Emory School of Medicine, Atlanta, GA, USA; 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, Surulere, P.M.B 12003, NigeriaCorrespondence: Sabdat Ozichu Ekama, Clinical Sciences Department, Nigerian Institute of Medical Research, 6 Edmund Crescent, Yaba, Lagos, P.M.B 2013, Nigeria, Tel +2348033220908, Email sabdatekama@gmail.comBackground: Female sex workers have a 13-fold higher risk of acquiring HIV than women who do not engage in sex work. …”
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Effects of Local Heating and Whole-Body Hyperthermia on Neuromuscular and Cognitive Function in Young and Old Healthy Adults by Junli Wang

“…Ankle muscle torque production and contractile properties were determined by isometric torque of the ankle plantar flexion and the isokinetic (dynamic) torque of the ankle plantar flexion/dorsiflexion muscles using an isokinetic dynamometer (System 4; Biodex Medical Systems, Shirley, NY, USA). In the second study, body surface area, heart rate, muscle temperature, and thermal sensation were measured. …”
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3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules by Woo-Youl Maeng, Yerim Lee, Szu-Han Chen, Kyung Su Kim, Daeun Sung, Wan-Ling Tseng, Gyu-Nam Kim, Young-Hag Koh, Yuan-Yu Hsueh, Jahyun Koo

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American Society for Gastrointestinal Endoscopy guideline on gastrostomy feeding tubes: methodology and review of evidence by Divyanshoo Rai Kohli, MD, Natalie Cosgrove, MD, Wasif M. Abidi, MD, PhD, Jorge D. Machicado, MD, MPH, Madhav Desai, MD, MPH, Nauzer Forbes, MD, MSc, Neil B. Marya, MD, Nikhil R. Thiruvengadam, MD, Nirav C. Thosani, MD, MHA, Omeed Alipour, MD, Saowanee Ngamruengphong, MD, Sherif E. Elhanafi, MD, Sunil G. Sheth, MD, Wenly Ruan, MD, John C. Fang, MD, Stephen A. McClave, MD, Rodrick C. Zvavanjanja, MD, MSc, FRCR(UK), FSIR, DABR(DR/VIR), Dhruvil K. Radadiya, MBBS, Amir Y. Kamel, PharmD, BCNSP, Bashar J. Qumseya, MD, MPH

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Social disconnectedness, subsequent medical conditions, and, the role of pre-existing mental disorders: a population-based cohort study by L. M. Laustsen, M. Lasgaard, N. C. Momen, D. Chen, J. L. Gradus, M. S. Grønkjær, M. M. Jensen, O. Plana-Ripoll

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