Pharmacognostic analysis and antimalarial evaluation of quercetin in Ilex umbellulata bark using HPTLC, in vitro screening, molecular docking, and network pharmacology by James H. Zothantluanga, Dipak Chetia, Yasangam Umbon, T. C. Lalhriatpuii, Dhritiman Roy, Nidahun Lamare, Salem Lalvenhimi

“…JazQSAR web tool previously developed by us predicts the IC50 of quercetin against Plasmodium falciparum as 3.88 ± 0.35 µM, which was not far from the practically observed value for quercetin. …”
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The influence of walking accessibility on station-to-station passenger flow and its interaction with metropolitan race/class segregation: A case study of MARTA’s heavy-rail network... by Luis Enrique Ramos-Santiago, Luke Derochers

“…Segregation because of class and/or race prejudice, often found in US cities, might yield spatial heterogeneity in whole-network DDM model parameters and introduce bias that could potentially mislead transit analysts, policy makers, and systemwide effectiveness. …”
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms by Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu

“…Comprehensive understanding on changes of gut microbiota during aging, in particular gut microbiota characteristics of centenarians, can provide us possibility to achieving healthy aging or intervene pathological aging through gut microbiota-directed strategies. …”
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Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS) by Habibul Ahsan, Farzana Jasmine, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Liz Stepniak, Rajan Gopalakrishnan, Andrew Craver, Paul Zakin, Saira Tasmin, Karen E Kim, Kathleen H Goss, Marcy List, Michelle LeBeau

“…Over 50% reported earning less than US$15 000 yearly, 35% were obese and 47.8% were current smokers. …”
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Personality's Time Perspective as a Resource for Overcoming the Identity Crisis at Different Stages of Life Realization by E.M. Meshcheryakova, A.V. Seryy, M.S. Yanitskiy

“…</strong>A set of diagnostic techniques aimed at studying the features of a personality's time perspective and the specifics of the manifestations of experiencing identity crises allowed us to collect data on samples formed in accordance with age periods. …”
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Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States by Pablo D. Jimenez Castro, Jennifer L. Willcox, Haresh Rochani, Holly L. Richmond, Heather E. Martinez, Cecilia E. Lozoya, Christian Savard, Christian M. Leutenegger

“…We acquired fecal surveillance data from a large population of dogs in the United States (US). A diagnostic test using real-time PCR (qPCR) for Ancylostoma spp. and allele-specific qPCR detecting the SNP F167Y in the isotype 1 of the Beta-tubulin gene, was used in 885,424 randomized canine fecal samples collected between March 2022 and December 2023. …”
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Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

“…Estimated PNS-related weighted average costs for the 60-Day PNS cohort [US$17,344; 95% confidence interval (CI): $16,168–$18,527] were lower than the PNS-BT cohort ($24,392; 95% CI $22,865–$25,941) when considering the percent of patients who advanced to a permanently implanted PNS system. …”
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Case report: Illustrating associated malignancies in Paget’s disease using contrast-enhanced mammography by Luciano Mariano, Luca Nicosia, Luca Nicosia, Anna Bozzini, Filippo Pesapane, Francesca Magnoni, Giovanni Mazzarol, Lorenza Meneghetti, Adriana Sorce, Enrico Cassano

“…These cases involved imaging techniques, including Digital Mammography (DM), Breast Ultrasound (US), MRI and CEM, alongside histopathological confirmation through nipple-areolar complex (NAC) punch biopsies. …”
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Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling s... by Matthew D Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I Aoko, Erick M Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B Shade, Gabriel Chamie, Laura B Balzer, Maya L Petersen, Diane V Havlir, Moses R Kamya, Andrew N Phillips

“…For our primary analysis, we used a cost-effectiveness threshold of US $500 per disability-adjusted life-year (DALY) averted, a 3% annual discount rate, and a 50-year time horizon. …”
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Simulations suggest offshore wind farms modify low-level jets by D. Quint, D. Quint, J. K. Lundquist, J. K. Lundquist, J. K. Lundquist, D. Rosencrans

“…<p>Offshore wind farms are scheduled to be constructed along the East Coast of the US in the coming years. Low-level jets (LLJs) – layers of relatively fast winds at low altitudes – also occur frequently in this region. …”
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Well-being balance and lived experiences: understanding the impact of life situations on human flourishing by Christopher R. Brydges, Alexandra Thérond, Troy W. Norris

“…BackgroundThis study aimed to determine the most significant indicators of positive well-being and understand differences in sources of well-being across different life situations, age groups, genders, and income levels, utilizing a novel measure of positive well-being, the Well-being Balance and Lived Experiences (WBAL) Assessment, which evaluates the frequency of various positive experiences and feelings across a range of activation and arousal levels that have previously been demonstrated to affect subjective well-being and human flourishing.MethodsA sample of 496 evaluable subjects aged 20-69 and census-balanced for gender were recruited from a U.S. population panel. Differences in well-being and sources of well-being were analyzed across subgroups via MANOVA analysis followed by post-hoc ANOVA and Tukey’s HSD analyses using Cohen’s d to determine size and direction of effects between categorical subgroups.ResultsLife situations, including relationship, parenting and employment status, were shown to have a more significant effect on overall well-being than the demographic variables of age, gender and household income. …”
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Neoplasms in the Nasal Cavity Identified and Tracked with an Artificial Intelligence-Assisted Nasal Endoscopic Diagnostic System by Xiayue Xu, Boxiang Yun, Yumin Zhao, Ling Jin, Yanning Zong, Guanzhen Yu, Chuanliang Zhao, Kai Fan, Xiaolin Zhang, Shiwang Tan, Zimu Zhang, Yan Wang, Qingli Li, Shaoqing Yu

“…The overall accuracy of the model established by us achieved an overall accuracy similar to that of residents (0.9707 ± 0.00984), while slightly lower than that of rhinologists (0.9790 ± 0.00348). …”
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Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…We related bird richness and abundance to disturbance (measured as the disturbance fraction, i.e. canopy gap area in relation to the total forest area per monitoring plot) derived from a 30 m-resolution forest disturbance layer based on Landsat satellite data. This allowed us to assess effects of young canopy gaps (disturbance <5 years ago) and older canopy gaps (disturbance 5–10 years ago) on population trends of single species, combined trends across functional groups and bird diversity. …”
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Mach Number Scaling of Foreshock Magnetic Fluctuations at Quasi-parallel Bow Shocks and Their Role in Magnetospheric Driving Throughout the Solar System by Brandon L. Burkholder, Li-Jen Chen, Katariina Nykyri, Norberto Romanelli, Menelaos Sarantos, Dave Sibeck, Jaye Verniero, Gina A. DiBraccio, Daniel Gershman, Martin Lindberg, Erin Kincade

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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…These results provided us with the rationale for elicitation of CTL responses targeting the WT1 product for cancer immunotherapy. …”
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Environmental Factors Affecting the Phytoplankton Composition in the Lake of Tibetan Plateau by Qinghuan Zhang, Zijian Xie, Chunhua Li, Chun Ye, Yang Wang, Zishu Ye, Weiwei Wei, Hao Wang

“…A clear understanding of the influential environmental variables affecting phytoplankton composition could help us to make proper water quality protection strategies in future climate change scenarios.…”
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Performance analysis of Leica Biosystems p16 monoclonal antibody in oropharyngeal squamous cell carcinoma by Selvam Thavaraj, Max Robinson, Shubham Dayal, Claire Bowen

“…Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death globally, with newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) cases rising to 54,000 in the US alone in the year 2022. Recently, human papilloma virus (HPV) infection was more prevalent in OPSCC patients than the traditionally known carcinogens such as tobacco or alcohol. …”
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Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice by Thomas Guerbette, Vincent Ciesielski, Manon Brien, Daniel Catheline, Roselyne Viel, Mégane Bostoën, Jean-Baptiste Perrin, Agnès Burel, Régis Janvier, Vincent Rioux, Annaïg Lan, Gaëlle Boudry

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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer by Anne Mills, Leisha A Emens, Mary L Disis, Kunle Odunsi, John B Liao, Tyler Curiel, Margaret Gatti-Mays, Amir Jazaeri, Emese Zsiros, Marcus O Butler, Jyoti Bajpai, Katherine C Kurnit, Haider Mahdi, Laura Doherty, Claire F Friedman, Melissa A Geller, Sarah F Adams, Shelley A Dodt, Veena S John

“…Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration for the treatment of cervical cancer and endometrial cancer, offering durable responses for some patients. …”
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The impact of architectural modifications on relative resistance to fluid flow in ventricular catheters by Rajesh Kumar Madhavan, Ahmad Faryami, Nathan Tappen, Pranav Gopalakrishnan, Shaheer H. Ajaz, Carolyn A. Harris

“…Relative resistance impacts fluid outflow efficiency, which may translate to clinical outcomes for hydrocephalus patients. These findings help us understand catheter architectural effects on resistance and inform future designs for specific ventricle morphologies.…”
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