Cancer phylogenetic tree inference at scale from 1000s of single cell genomes by Salehi, Sohrab, Dorri, Fatemeh, Chern, Kevin, Kabeer, Farhia, Rusk, Nicole, Funnell, Tyler, Williams, Marc J., Lai, Daniel, Andronescu, Mirela, Campbell, Kieran R., McPherson, Andrew, Aparicio, Samuel, Roth, Andrew, Shah, Sohrab P., Bouchard-Côté, Alexandre

“…The sitka transformation allows us to design novel scalable Markov chain Monte Carlo (MCMC) algorithms. …”
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Identifying barriers and potential solutions to improve equitable access to community eye services: an exploratory sequential mixed methods study protocol by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, Sailesh Mishra, Shalinder Sabherwal, Luke Nelson Allen, Abhishek Roshan, Sarah Karanja, Ari Ho-Foster, Keneilwe Motlhatlhedi, Nigel Bolster, Mohd Javed, Malebogo Tlhajoane, Bakgaki Ratshaa, John Tlhakanelo

“…We aim to use rapid yet robust mixed methods that allow us to identify generalisable findings within each programme and testable service modifications to improve equitable access to care; delivering non-tokenistic findings within a matter of weeks.Methods and analysis This is a multiphased exploratory sequential mixed methods study. …”
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QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) by Osama Dasa, Eileen Handberg, Damini Dey, Pinaki Sarder, Margaret C. Lo, Balaji K. Tamarappoo, Steven M. Smith, Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine

“…Background: Cardiovascular disease is the leading cause of death among women in the US, predominantly due to ischemic heart disease (IHD). …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Conclusions: Our findings offer evidence for single and mixed associations of BFRs and NAFLD in ordinary US adults. Furthermore, oxidative stress and chronic inflammation may mediate the effects of BFR exposure on NAFLD development.…”
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Sensitivity to the Demethylation Inhibitor Difenoconazole Among Baseline Populations of Various <i>Penicillium</i> spp. Causing Blue Mold of Apples and Pears by Madan Pandey, Clayton L. Haskell, Juliette D. Cowell, Achour Amiri

“…., <i>P. solitum</i> (<i>n</i> = 52), <i>P. roqueforti</i> (<i>n</i> = 32), <i>P. commune</i> (<i>n</i> = 15), <i>P. paneum</i> (<i>n</i> = 9), <i>P. psychrosexuale</i> (<i>n</i> = 8), <i>P. crustosum</i> (<i>n</i> = 5), <i>P. carneum</i> (<i>n</i> = 3), <i>P. palitans</i> (<i>n</i> = 2), along with one isolate each of <i>P. citrinum</i>, <i>P. griseofulvum</i>, <i>P. raistrickii</i>, <i>P. ribium</i>, and <i>P. viridicatum</i>, were collected from multiple packinghouses in the U.S. Pacific Northwest. In vitro sensitivity assays showed similar sensitivities of spores and mycelia across species with the mean EC₅₀ values ranging from 0.01 for <i>P. psychrosexuale</i> (<i>n</i> = 8) to 1.33 μg mL⁻¹ for <i>P. palitans</i> (<i>n</i> = 2), whereas the mean EC_50s were 0.03, 0.12, 0.19, and 0.51 μg mL⁻¹ for <i>P. expansum</i> (<i>n</i> = 31), <i>P. paneum</i> (<i>n</i> = 9), <i>P. solitum</i> (<i>n</i> = 52), and <i>P. crustosum</i> (<i>n</i> = 5), respectively. …”
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Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided ca... by Ying Zhou, Chen Cheng, Qi Wang, Min Zheng, Pan Li, Yang Zhou, Yuting Cao, Li Wan, Xun Guo, Xiaohong Lin, Rui Tang, Hongye He, Nianhong Wu, Qiaoqi Chen, Yaqin Hu, Xialin Xiong, Faqi Li

“…Flow cytometry and immunofluorescence were used to clarify the potential mechanism of HIFU+M@P-SOP and their role in anti-programmed death ligand-1 (PD-L1) therapy.Results Guided by photoacoustic/MR/ultrasound (US) multimodal imaging, M@P-SOP was abundantly enriched in tumor, which greatly enhanced HIFU’s killing of tumor tissue in situ, induced stronger tumor immunogenic cell death, stimulated dendritic cell maturation and activated CD8+ T cells. …”
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Dissemination of the Russian emigrant literature and the literature of the Book Program in East Europe in 1950-1990 by Alvydas Kazakevičius

“…Alongside the Russian émigré organizations, Russian books abroad were published by the so-called Book Program, Book Exchange Program, religious missions, and some Russian émigré periodicals. In 1950-1956, U.S. governmental institutions adopted the main idea of NTS ideologist and one of its leaders, V. …”
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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis by Xiang Li, Gao He, Hui Jin, Xinyu Xiang, Dong Li, Renmiao Peng, Jing Tao, Xinping Li, Kaiyang Wang, Yu Luo, Xiaoan Liu

“…The external ultrasound (US) activates PpIX to generate ROS, which breaks the linker to release aPD‐L1 to induce sonodynamic therapy (SDT) and immunotherapy. …”
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Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People by Weiwei Hu, Jinwei He, Luyue Qi, Chun Wang, Hua Yue, Jiemei Gu, Hao Zhang, Yi Wang, Zhenlin Zhang

“…These results provide important information for us to further understand the etiology and genetic pathogenesis of osteoporosis. …”
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Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Anderson worked for the US Anti-Doping Agency, answering calls on the Drug Reference Line, creating drug information materials for elite athletes and the public, and leading the ingredient management for the search engine called Global DRO. …”
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Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort... by Raj Tummala, Richard A Furie, Laurent Arnaud, Eric F Morand, Martin Aringer, Stephanie Chen, Barnabas Desta, Alberta Hoi, Bo Ding, Christine Peschken, Jonatan Hedberg, Tina Grünfeld Eén, Alessandro Sorrentino, Danuta Kielar

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Investigating the association of traditional and non-traditional tobacco product use with subclinical and clinical cardiovascular disease: The Cross-Cohort Collaboration- Tobacco w... by Erfan Tasdighi, Kunal K. Jha, Zeina A. Dardari, Ngozi Osuji, Tanuja Rajan, Ellen Boakye, Michael E. Hall, Carlos J. Rodriguez, Andrew C. Stokes, Omar El Shahawy, Emelia J. Benjamin, Aruni Bhatnagar, Andrew P. DeFilippis, Michael J. Blaha

“…The Cross-Cohort Collaboration (CCC)-Tobacco is a harmonized dataset of 23 prospective cohort studies predominantly in the US. A priori defined variables collected from each cohort included baseline characteristics, details of traditional and non-traditional tobacco product use, inflammatory markers, and outcomes including subclinical and clinical CVD. …”
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Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center by Simona Fecarotta, Lorenzo Vaccaro, Alessandra Verde, Marianna Alagia, Alessandro Rossi, Chiara Colantuono, Maria Teresa Cacciapuoti, Patrizia Annunziata, Sara Riccardo, Antonio Grimaldi, Tonya Fusco, Rosa De Santis, Fernando Barretta, Lucia Albano, Daniela Crisci, Fabiana Vallone, Antonietta Tarallo, Marcella Cesana, Nicola Brunetti-Pierri, Giulia Frisso, Margherita Ruoppolo, Davide Cacchiarelli, Giancarlo Parenti

“…In total, we could identify 17 affected, 34 false positives, 12 individuals referred to us for maternal conditions. In 45 newborns the molecular analysis showed heterozygosity for mutations in one or more of the genes analyzed, with results compatible with the biochemical profile indicative of NBS positivity. …”
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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…More detailed investigations, with targeted knockouts of CWI and SIN signaling proteins, enabled us to identify crosstalk occurring between the CWI kinase, MpkA, and the SIN kinase, SepH. …”
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On the feasibility of monitoring the content of phenolic compounds in transformer oil by M. N. Lyutikova, S. V. Nekhoroshev, V. M. Muratova, P. R. Semenyuk, A. S. Gadzhiyeva

“…Changes in additive concentrations during oil aging are controlled using a new technique developed by us, based on IR spectroscopy. …”
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Health effects of mixed metal exposure on accelerating aging among the elderly population by Chuanli Yang, Jijun Zhang, Haohan Liu, Qin Hong, Yunhe Fan, Jie An, Haijia Zhang, Xiaobing Shen, Xiushan Dong

“…However, the effects of mixed heavy metal exposure on accelerated aging in the elderly U.S. population remains unclear. This study aims to investigate the association between heavy metal concentrations in blood and urine and the onset of accelerated aging. …”
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Associations between Prospective Memory, Executive Function and Physical Activity in Schoolchildren by Anouk Irina Glättli, Markus Gerber, Sebastian Ludyga

“… Introduction Prospective memory refers to a system that allows us to remember to perform an intended task without an explicit reminder. …”
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Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…To bridge this gap, we employed hidden Markov models to systematically search in a large-scale and high-quality search library comprising 28,813 RefSeq multi-kingdom microbial complete genomes, enabling us to construct a secondary bile acid production gene catalog. …”
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Point-of-care tests in the emergency medical services: a scoping review by T. H. M. Moore, S. Dawson, K. Kirby, R. Body, A. Thompson, Y. O. Adepoju, R. Perry, H. Nicholson, J. Dinnes, K. Mitchell, J. Savović, S. Voss, J. R. Benger

“…The majority of research was done in the UK (19%), US (17%), and the Netherlands (16%), mostly in land-based EMS (82%). …”
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Determinants of Parental Attitudes towards Children’s Vaccination in Lithuania: An Online Survey by Kamilė Čeponytė, Eglė Narkevičiūtė, Aušra Beržanskytė, Sigita Burokienė

“…Open-text survey responses gave us more in-depth insight about the parental decision-making process. …”
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