Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial by Mark Conaway, David R Boulware, Scott K Heysell, Stellah G Mpagama, Christopher C Moore, Alphonce Liyoyo, Conrad Muzoora, Catherine Gitige, Bibie Said, Edwin Nuwagira, Rinah Arinaitwe, Rhina Mushagara, Peter Buzaare, Anna Chongolo, Samuel Jjunju, Precious Twesigye, Megan Null, Tania A Thomas

“…The study is funded by the National Institutes of Health in the US. Institutional review board approval was conferred by the University of Virginia, the Tanzania National Institute for Medical Research, and the Uganda National Council for Science and Technology. …”
Get full text

Unraveling landslide failure mechanisms with seismic signal analysis for enhanced pre-survey understanding by J.-M. Chang, J.-M. Chang, C.-M. Yang, W.-A. Chao, W.-A. Chao, C.-S. Ku, M.-W. Huang, M.-W. Huang, T.-C. Hsieh, C.-Y. Hung

“…These techniques enable us to determine the physical processes, sliding direction, mass amount estimation, and location of the deep-seated landslide. …”
Get full text

Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions by Yan Zhang, Dou Du, Chao Fang, Xin Yu, Yujia Fang, Xinyu Liu, Di Ou, Haohao Yin, Hui Liu, Taixia Wang, Lu Lu, Xiaolong Li, Kun Zhang

“…Such a deubiquitination-engineered disruption approach finds an unprecedented pathway to disarm deubiquitination-induced resistances to SDT and other ROS-based anti-tumor means, which also enlightens us to establish other post-transcriptional epigenetic modification disruption strategies to re-program the tumor microenvironment and elevate the anti-tumor efficiency of various treatment methods (e.g., immunotherapy).…”
Get full text

Security and religion in democratizing Tunisia: re-enacting surveillance through religious narratives and gendered dynamics by Fabrizio Leonardo Cuccu, Alessandra Bonci

“…The analysis of the work of wa’ydhat allows us to highlight the connections between local and global narratives of security, which emphasize the role of women as central in the fight against terrorism due to their purported inherent “peaceful” qualities, and their actual role as watchers within a system of surveillance and control. …”
Get full text

Geographically widespread and novel hemotropic mycoplasmas and bartonellae in Mexican free-tailed bats and sympatric North American bat species by Daniel J. Becker, Kristin E. Dyer, Lauren R. Lock, Beckett L. Olbrys, Shawn A. Pladas, Anushka A. Sukhadia, Bret Demory, Juliana Maria Nunes Batista, Micaela Pineda, Nancy B. Simmons, Amanda M. Adams, Winifred F. Frick, M. Teague O'Mara, Dmitriy V. Volokhov

Get full text

The association of energy or macronutrient intake in three meals with depression in adults with cardiovascular disease: the United States National Health and Nutrition Examination... by Hongquan Xie, Yueying Chen, Jijiao Tang, Yuteng Ma, Ying Liu, Xiyun Ren

“…Methods The study population consisted of 3,490 U.S. adults with CVD (including 554 with depression) from the National Health and Nutrition Examination Survey 2003–2018. …”
Get full text

Rationale and design for Healthy Hearts in Manufacturing (HHM): A pragmatic single-arm hybrid effectiveness-implementation study for hypertension management and tobacco cessation by Hanzi Jiang, Yao Tian, Jennifer Bannon, Amy E. Krefman, Lawrence C. An, Dustin D. French, Claude R. Maechling, Jane Holl, Richard Chagnon, Theresa L. Walunas, Christopher Burch, Anthony Musci, Darce Latsis, Dawn Carey, Megan McHugh

“…The HHM intervention involves monthly coaching to assist WHCs with implementing evidence-based strategies for hypertension management and tobacco cessation advocated by the Million Hearts initiative and the U.S. Preventive Services Task Force. A pragmatic, Type II hybrid effectiveness-implementation study design is used to evaluate HHM. …”
Get full text

Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81 by Rehaiem Amel, Bouzouita Abderrazek, Ferjani Sana, Saadi Ahmed, Zrelli Mariem, Kanzari Lamia, Ferjani Asma, Mohamed Riadh Ben Slama, Boutiba Ben Boubaker Ilhem

“…Allelic variation allows us to report earliest the qnrB81 determinant in an E. coli isolate. …”
Get full text

Network Design and Route Analysis Using Outside Plant by Isaac Adjaye Aboagye, Nii Longdon Sowah, Wiafe Owusu-Banahene, Aryee Shaelijah, Margaret Ansah Richardson, Emmanuel Baah-Boadi

“…Also, the design methodology helped us to develop a backbone network to get closer to the various homes and premises. …”
Get full text

The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis by Shanshan Chen, Shanshan Chen, Changde Wu, Zhaojie Zhang, Lingjuan Liu, Yike Zhu, Dingji Hu, Chenhui Jin, Haoya Fu, Jing Wu, Songqiao Liu, Songqiao Liu, Songqiao Liu

“…Core authors and institutions, primarily from the U.S. and Germany, are driving research in this field. …”
Get full text

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure by Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

Get full text

Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…Specifically, imagery from Landsat-5 (2010−2013) and Landsat-8 (2014–2022), obtained from the US Geological Survey (USGS), was employed. Statistical analyses, including Pearson's correlation and linear regression, were conducted to assess relationships between these variables from 2010 to 2022. …”
Get full text

Shifts in the rhizosphere microbiome and exudation profile of avocado (Persea americana Mill.) during infection by Phytophthora cinnamomi and in presence of a biocontrol bacterial... by Frédérique Reverchon, Mariel García-Meléndez, Edgar Guevara-Avendaño, Oscar Mora-Chávez, Itzel A. Solís-García, Wesley Dáttilo, José A. Guererro-Analco, Alfonso Méndez-Bravo, Juan L. Monribot-Villanueva, Violeta Patiño-Conde, Fernando Pineda-García, Eria A. Rebollar

“…Understanding the effect of P. cinnamomi or a BCA on the avocado tree physiology and on the avocado rhizosphere microbiome and metabolome will direct our search for disease biomarkers or potential pathogen antagonists, help identify metabolites related to the recruitment of microorganisms, and assist us in developing integrated disease management strategies.…”
Get full text

High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…We utilised a high-throughput untargeted metabolomics approach in a total of 962 pigs that allowed us to detect and relatively quantify 722 metabolites from various biological classes. …”
Get full text

The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling by Wang C, Lu Z, She G, Chen K, Zhou H, Zhan X, Yu H, Pi L, Zuo L, Che D

“…We performed the proximity barcoding assay (PBA) to analyze single exosome surface proteins, which allowed us to identify individual exosomes related to the development of RA as well as the major subpopulations of exosomes. …”
Get full text

Evaluation of the influence of offshore wind farm noise on the fishes and dolphins in the Pearl River Estuary by Zhongchang Song, Weijie Fu, Hongquan Li, Yingnan Su, Zhanyuan Gao, Wenxin Fan, Jiangang Hui, Wenzhan Ou, Shengyao Sun, Teng Wang, Honghui Huang, Yu Zhang

“…Our findings underscore the importance of increasing our understanding on hearing sensitivities of the local inhabitants in the Pearl River Estuary and identify their core habitats. This approach enabled us to use the model to estimate impact zones and better protect the local marine life from the effects of pile driving noise radiation.…”
Get full text

Regional climatic changes and their impact on the level of avalanche hazard in East Kazakhstan by Olga Petrova, Natalya Denissova, Gulzhan Daumova, Yelena Ivashchenko, Evgeny Sergazinov

“…The results obtained in the study will help us to better understand the regional manifestations of climate change. …”
Get full text

Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…Funding: This research was supported by US National Cancer Institute grant R37CA248289, and Sylvester Comprehensive Cancer Center. which receives funding from the National Cancer Institute award P30CA240139. …”
Get full text

Blood proteomics and multimodal risk profiling of human volunteers after incision injury: A translational study for advancing personalized pain management after surgery by Daniel Segelcke, Julia R. Sondermann, Christin Kappert, Bruno Pradier, Dennis Görlich, Manfred Fobker, Jan Vollert, Peter K. Zahn, Manuela Schmidt, Esther M. Pogatzki-Zahn

“…A combinatorial set of distinct features enabled us to predict outcome measures with increased accuracy compared to using single features. …”
Get full text

Exploraciones personales sobre las condiciones precedentes de la violencia sexual en el marco del conflicto armado enColombia by Paula Natalia Rincón Chitiva, Juan Felipe Monroy Simbaqueba

“…The research invokes the use of literary tools (four short stories written by us) and states through non-academic language of the personal repercussions during the realization of this investigation.…”
Get full text