Assessing the Health and Economic Outcomes of a 9-Valent HPV Vaccination Program in the United Kingdom by Kwame Owusu-Edusei, Cody Palmer, Olga Ovcinnikova, Giampiero Favato, Vincent Daniels

“…**Objective:** To estimate and compare the health and economic outcomes of 2 HPV vaccination programs in the UK targeting girls and boys aged 12-13 years from the perspective of the UK National Health Service. …”
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Interrogating green social prescribing in South Wales; A multi-stakeholder qualitative exploration. by Menna Brown, Katharine Sarah Aylett

“…Globally healthcare systems are struggling to cope with the increasing demands of an ageing population and the NHS (UK) is no exception. Social prescribing is heralded as a means to relieve the burden on primary care and provide support for the 20% of patients whose needs are non-medical. …”
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Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis by Paul Roderick, Peter Clive Hayes, Julie Parkes, Ryan Buchanan, Oliver John Kennedy, Jonathan Andrew Fallowfield

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Return to play following craniotomy for non-traumatic brain lesions by Jovanna A. Tracz, Matthew L. Farmer, Mark Hughes, Debraj Mukherjee, Paul M. Brennan

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Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study by Neil A Harrison, Hugo D Critchley, Jessica Eccles, Kevin A Davies, Lisa Quadt, Rod Bond, Jenny Csecs

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New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

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Comparisons of risk factors and outcomes between abdominal aortic aneurysm and peripheral arterial disease: a case-control study by Ian Beeton, Jay Acharya, Bengisu Kesin Meric, James Hobden, Tahir Ali, Thang S. Han

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Neighbourhood socioeconomic conditions and emergency admissions for ambulatory care sensitive conditions in children: a longitudinal ecological analysis in England, 2012–2017 by Bernie Carter, Enitan D Carrol, David Taylor-Robinson, Konstantinos Daras, Tanith Rose, Kate Mason, Courtney Franklin, Lateef Akanni

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Difficulties faced by physicians from four European countries in rebutting antivaccination arguments: a cross-sectional study by Fernanda Rodrigues, Cornelia Betsch, Pierre Verger, Harriet Fisher, Philipp Schmid, Dawn Holford, Angelo Fasce, Amanda Garrison, Linda Karlsson, Frederike Taubert, Stephan Lewandowsky, Anna Soveri

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Association between guidelines and medical practitioners’ perception of best management for patients attending with an apparently uncomplicated acute sore throat: a cross-sectional... by Alastair D Hay, Mark H Ebell, Ronny Gunnarsson, Pär-Daniel Sundvall, Katarina Hedin, Hannelore Wächtler, Naveen Manchal, Lynne Reid, Stefan Malmberg, Sean Hawkey

“…The UK guideline was the only one actively discouraging the use of throat swabs. …”
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Changing the trajectories of mental health difficulties in Norfolk and Suffolk: a research-priority-setting project with patients, the public, clinicians, policymakers and other st... by Caitlin Notley, Jayati Das-Munshi, Craig Morgan, Kristy Sanderson, Sherifat Oduola, Zarnie Khadjesari, Helen Parretti, Niall Broomfield, Amy Zile, Sol Morrissey, Joni Holmes

“…Consisting of largely coastal and rural communities, the populations of Norfolk and Suffolk, UK, have elevated burdens of mental health problems, areas with high levels of deprivation and an increasing migrant population. …”
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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination... by Abhishek Abhishek, Jonathan A Cook, Helen M Parry, Anne Francis, Lelia Duley, Vicki S Barber, Paul Moss, Nicholas Peckham

“…This study aims to determine in patients with chronic lymphocytic leukaemia (CLL) if a 3-week pause in Bruton tyrosine kinase inhibitor therapy (BTKi) starting 1 week before delivery of SARS-CoV-2 vaccine booster, improves vaccine immune response when compared with continuation of BTKi.Methods and analysis An open-label, randomised controlled superiority trial will be conducted in haematology clinics in approximately 10 UK National Health Service (NHS) hospitals. The sample size is 120, randomised 1:1 to intervention and usual care arms. …”
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Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis by Peter Anderson, Eileen F S Kaner, Jakob Manthey, Jürgen Rehm, Amy O'Donnell, Eva Jané Llopis

“…Objective To assess the immediate impact of the introduction of minimum unit pricing (MUP) in Scotland on alcohol consumption and whether the impact differed by sex, level of alcohol consumption, age, social grade and level of residential deprivation of respondents.Design Primary controlled interrupted time series analysis and secondary before-and-after analysis of the impact of introducing MUP in Scotland using alcohol consumption data for England as control.Setting Data from Kantar Worldpanel’s Alcovision survey, a continuous retrospective online timeline follow-back diary survey of the previous week’s alcohol consumption.Participants 53 347 women and 53 143 men.Interventions Introduction of a minimum price of 50 pence per UK unit (6.25 pence/g) for the sale of alcohol in Scotland on 1 May 2018.Main outcome measures Number of grams of alcohol consumed per week, in total, in off-trade (eg, at home) and in on-trade (eg, in pubs, restaurants).Results Primary interrupted time series analyses found that the introduction of MUP was associated with a drop in reported weekly total alcohol consumption of 5.94 g (95% CI 1.29 to 10.60), a drop in off-trade consumption of 3.27 g (95% CI −0.01 to 6.56) and a drop in on-trade consumption of 2.67 g (95% CI −1.48 to 6.82). …”
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Giacomo Bonan and Katia Occhi (eds), Environment and Infrastructure. Challenges, Knowledge and Innovation from the Early Modern Period to the Present by Sebastian De Pretto

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Reviewer acknowledgement by Fares S. Haddad

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Digital Engagement in the Public Sector by Ece Dündar, Zeynep Tuba Sungur

“…In-depth examination of how UK Government Departments are engaging digitally with their stakeholders and wider public.…”
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Role of psychiatrists in early diagnosis and treatment of OCD by Ilenia Pampaloni

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Editorial: Our Creative Selves by Emma Gillaspy, Anna Hunter, Neil Withnell, Chrissi Nerantzi

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Transcription factor networks de-liver insight into improving organoid-derived hepatocyte culture by Katie Pickup

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