Adverse events and overall health and well-being after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study by Thomas M MacDonald, Andrew Duncan, Amy Rogers, Greg Guthrie, Alex Doney, Steve Morant, Isla Mackenzie, Evelien Rooke, Rebecca Barr, Filippo Pigazzani, Krists Zutis

“…Objectives To describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health and well-being after COVID-19 vaccination.Design VAC4COVID is an ongoing prospective, active observational, post-authorisation cohort safety study (PASS) of UK-approved vaccines for COVID-19 disease.Setting The study is conducted through a secure website (www.vac4covid.com) by MEMO Research, University of Dundee, UK.Participants 16 265 adult (18 years or older) UK residents with a valid email address and internet access.Interventions Any UK-authorised COVID-19 vaccination.Main outcome measures The outcomes reported in this interim analysis include AEs, reactogenicity-type AEs (headache, fatigue, muscle or joint pain, fever, nausea, dizziness or local vaccine reaction), menstrual changes and reported improvement in overall health and well-being.Results 11 475 consented participants (mean age 54.8 years) provided follow-up data between 2 February and 5 October 2021 (mean follow-up duration 184 days), by which date 89.2% of participants had received two vaccine doses. 89.8% of 5222 participants who completed a follow-up questionnaire in the 7 days after any COVID-19 vaccination reported no AEs. …”
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HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol by Neil Ashman, Ben Caplin, David Wheeler, Tahseen Ahmad Chowdhury, Kieran Mccafferty, Sinead Knight, Paul Hockings, Stanley L Fan, Johannes Hulthe, Robert Kleta, Vasilios Papastefanou, Hemal Mehta, Alan Salama, Sinela Hadzovic, Lisa Jarl, Robert Unwin, Benjamin Challis, Anna K Sundgren, Muhammad Magdi Yaqoob

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A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

“…Background: UK clinical guidelines recommend supervised exercise training and support for health behavior change for patients with peripheral arterial disease (PAD). …”
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Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial by Yongli Tao, Yuan Gao, Lu Zhao, Yafang Xu, Chenyang Jiang, Kai Liu, Hui Fang, Lulu Pei, Xin Wang, Rui Zhang, Jun Wu, Jing Yang, Xinsheng Han, Hongling Guo, Baoguo Xue, Jinlou Li, Yuqian Liu, Hongqiu Gu, Kejin Du, Xin Cheng, Qiang Dong, Duolao Wang, Ferdinando S. Buonanno, MingMing Ning, Yuming Xu, Bo Song, the TRUST Trial Investigators

“…Eligible patients were randomized to the UK group (1,000,000 U) or the best medicine treatment group. …”
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Bringing the words out of the Montessori box: Towards a Montessori system for enhancing language development from birth to six years by Helen Prochazka

“… Anecdotal evidence from early years practitioners in the UK reflects a perception of gradual, but per­sistent, decline in the extent of native English-speaking children’s vocabulary and oral communication skills when they start nursery aged 2–3 years. …”
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Biomechanical disparities in pankration: A comparative computational analysis of ancient and contemporary techniques by Bourantanis Andreas G., Nomikos Nikitas N., Nikolaidis Pantelis T., Yiannakopoulos Chris K., Aggelousis Nikolaos G., Wang Weijie W.

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Constructions of Space: Exploring Photographic Images in Forest School by Ange Garden

“…Working with the same group of 32 Key Stage 2 children selected from two UK primary schools, the research explored the images captured on iPad cameras during the follow-on session. …”
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Partition regularity of Pythagorean pairs by Nikos Frantzikinakis, Oleksiy Klurman, Joel Moreira

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Author Correction: Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

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COVID-19 and Scottish Independence: The Instrumentalisation of the Pandemic in the Constitutional Debate by Nelly Gérard

“…The Covid-19 pandemic unfolded in the UK in a specific context where, in the aftermath of the Brexit referendum, much of the political scene had been dominated by constitutional politics. …”
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On well-posedness of the nonlocal boundary value problem for parabolic difference equations by A. Ashyralyev, I. Karatay, P. E. Sobolevskii

“…We consider the nonlocal boundary value problem for difference equations (uk−uk−1)/τ+Auk=φk, 1≤k≤N, Nτ=1, and u0=u[λ/τ]+φ, 0<λ≤1, in an arbitrary Banach space E with the strongly positive operator A. …”
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