Impact on staff of providing non-invasive advanced respiratory support during the COVID-19 pandemic: a qualitative study in an acute hospital by David Wenzel, Christina Faull, Eleanor Wilson, Lucy Bleazard

“…Objectives To explore the experiences of healthcare workers providing non-invasive advanced respiratory support (NARS) to critically unwell patients with COVID-19.Design A qualitative study drawing on a social constructionist perspective using thematic analysis of semistructured interviews.Setting A single acute UK National Health Service Trust across two hospital sites.Participants Multidisciplinary team members in acute, respiratory and palliative medicine.Results 21 nurses, doctors (juniors and consultants) and physiotherapists described the provision of NARS to critically unwell COVID-19 patients as extremely challenging. …”
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Meta-models for transfer learning in source localization by Lawrence A. Bull, Matthew R. Jones, Elizabeth J. Cross, Andrew Duncan, Mark Girolami

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Improving eating disorder care for underserved groups: a lived experience and quality improvement perspective by Alykhan Asaria

“…As I live in the UK, my lived and QI experiences are of the UK’s National Health Service (NHS). …”
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‘We are not trained to do clinical work’: security staff providing physical restraint for NGT feeding in English paediatric wards—a qualitative multi-informant study by Dasha Nicholls, Jacinta Tan, Sarah Fuller, Emerie Sheridan

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The Present and the Future of the Special Relationship: The Debate in the United States and the United Kingdom by A. O. Mamedova

“…Since World War II U.S.–UK relations, despite occasional ups and downs, have been characterized by an unprecedented level of mutual trust and cooperation. …”
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Life expectancy of cats in Britain: moggies and mollies live longer by Fernando Mata

“…This study aims to expand on previous UK research by analyzing these interactions and highlighting the potential negative impacts of pure breeding on cat health. …”
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Relationships between sodium, fats and carbohydrates on blood pressure, cholesterol and HbA1c: an umbrella review of systematic reviews by Sarah Abraham, Katie Sworn, Anna Cantrell, Penny Breeze, Ellen McGrane

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Generation of an induced pluripotent stem cell line (UCLi026-A) from a patient with ADCY5-related disease carrying the heterozygous variant c.1253G > A; (p. Arg418Gln) by Sharmin Alhaque, Dimitri Budinger, Barbara Garavaglia, Giovanna Zorzi, Serena Barral, Manju A. Kurian

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Reflections at the Crossroads by Terry McDonough

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Multicentre, randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates (Petal) by Eleri Adams, Daniel Crankshaw, Ria Evans Fry, Rebeccah Slater, Caroline Hartley, Maria M Cobo, Fiona Moultrie, Annalisa G V Hauck, Vaneesha Monk, Shellie Robinson, Marianne van der Vaart, Luke Baxter, Ravi Poorun, Aomesh Bhatt

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Surgical Treatment Intensity at the End of Life in Patients With Cancer: A Systematic Review by Samuel Lawday, BMBS, MByRes, Benjamin E. Zucker, MA, MBBS, MRCS, Shona Gardner, MBChB, MRCS, James Robb, MBChB, MA, Lorna Leandro, MA, BM, BCh, William Hollingworth, PhD, Jane Blazeby, MBChB, MD, Angus G.K. McNair, PhD, FRCS, Charlotte Chamberlain, PhD, MRCP

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Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…Digital technologies may help address this, and this trial will evaluate the feasibility and acceptability of two electronic-rehabilitation interventions: ‘My Knee UK’ and ‘Group E-Rehab’.Methods and analysis This protocol describes a non-blinded, randomised feasibility trial with three parallel groups. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…Prehypertension is a warning of development of hypertension as well as a risk for cardiovascular disease, heart attack and stroke. In the UK, non-pharmacological interventions are recommended for prehypertension management but no reviews have focused on the effectiveness of these types of interventions solely in people with prehypertension. …”
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Measures of social connectedness in adult populations: a systematic review by Ruth Plackett, Joe Hulin, Clara Mukuria, Mark Clowes, Sheena E. Ramsay, Liam Spencer, Emma A. Adams, Jennifer Dykxhoorn, Kate Walters, David P. J. Osborn, Victoria Zamperoni, Oliver Jones, Scott Weich

“…Conclusions This review identified ten social connectedness measures, and identified UCLA-3, MSPSS, F-SozUK-6, SPS-10, and SPS-5 as having the most robust psychometric properties for the UK adult population. …”
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Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…Objective To confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.Design A nested case–control study.Setting 1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.Participants Baseline cohort included 16.8 million individuals aged 18 years and over without a diagnosis of MND at study entry and with more than 3 years of digitalised information available. …”
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Obesity in pregnancy: infant health service utilisation and costs on the NHS by Ronan A Lyons, Ashrafunnesa Khanom, Sinead T Brophy, Kelly L Morgan, Muhammad A Rahman, Rebecca A Hill

“…Objective To estimate the direct healthcare cost of infants born to overweight or obese mothers to the National Health Service in the UK.Design Retrospective prevalence-based study.Setting Combined linked anonymised electronic data sets on a cohort of mother–child pairs enrolled on the Growing Up in Wales: Environments for Healthy Living (EHL) study. …”
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Efficacy of Adjunctive Antiseptic Lavage Solution in Managing Acute Hip/Knee Prosthetic Joint Infection: A Comparative Study in a Tertiary Revision Center by Jonathan Quinn, FRACS, Bernard H. van Duren, DPhil, FRCS, Reshid Berber, PhD, FRCS, Mark Higgins, FRCS, Hosam E. Matar, FRCS, Andrew R. Manktelow, FRCS, Benjamin V. Bloch, FRCS

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Considering best practice standards for routine whole-genome sequencing for TB care and control by J.T. Denholm, G. de Vries, R. Anthony, E. Robinson, M. Backx, I.F. Laurenson, A.L. Seagar, H. Modestil, L. Trieu, J.S. Meissner, D.H.L. Ng, J.Y. Tay, H.H. Lin, R. Lee, V. Sintchenko, B.J. Marais, E.J. Donnan

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