Exploring public support for novel tobacco and alcohol control policies in Great Britain 2021–2023: A population-based cross-sectional survey by Vera Helen Buss, Lion Shahab, Sharon Cox, Loren Kock, Melissa Oldham, Linda Bauld, Hazel Cheeseman, Garth Reid, Jamie Brown

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Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carbo... by Michelle Lockley, Kathy Robinson, Rowan Miller, Charlie Gourley, Nicholas Counsell, Iain Mcneish, Trevor Graham, Uma Anne Mukherjee, Helen Hockings, Apini Patel, Priya Narayanan, Katie Wilkinson, Harjot Dhanda, Alexander R A Anderson

“…ACTOv is open to National Health Service hospitals throughout the UK, recruitment is anticipated to take 36 months across 10 sites and will be managed by the Cancer Research UK and University College London Cancer Trials Centre.Ethics and dissemination The trial has been reviewed and received approval from the London—Dulwich Research Ethics Committee (REC). …”
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Nurture-U student mental health longitudinal survey: a study protocol by Kate E Saunders, Samuel R Chamberlain, Jemima Dooley, Edward R Watkins, Liz Forty, Sarah Rees, Anne C Duffy, Anthony Quinn, Ellen Marshall, Lucy Dorey, Kevin A Matlock, Alexandra Newbold, Lucy J Robinson

“…This study aims to address gaps in longitudinal data on student mental health in the UK and to identify risk and protective factors across diverse student populations.Methods and analysis The current Nurture-U survey is developed from the U-Flourish biannual survey study piloted at Queen’s and Oxford universities in Canada and the UK, respectively. …”
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BSG 2024 IBD guidelines protocol (standard operating procedures) by Philip Smith, Rachel Cooney, Jimmy Limdi, Sreedhar Subramanian, Polychronis Pavlidis, Ajay Verma, Said Din, Gordon W Moran, Naila Arebi, Shahida Din, Morris Gordon, Kamal V Patel, Klaartje Bel Kok, Dennis McGonagle, Matthew Shale, Ana-Maria Darie, Vasiliki Sinopoulou, Newton A C S Wong

“…Based on the available evidence, some of the recommendations will be based on GRADE while others will be best practice statements.A full Delphi process will be used to make recommendations using online response systems.This set of procedures has been approved by the Clinical Services and Standards Committee, the British Society of Gastroenterology executive board and aligned with IBD UK standards.…”
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Reply to: “Understanding virologic heterogeneity in chronic hepatitis B treatment” by Philippa C. Matthews, Tingyan Wang, Eleanor Barnes

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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Introduction Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (allo-SCT), affecting 30–70% of patients (representing 800 new patients per year in the UK). The risk is higher in patients undergoing unrelated allo-SCT. …”
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AI-assisted detection for chest X-rays (AID-CXR): a multi-reader multi-case study protocol by Fergus Gleeson, Alex Novak, Indrajeet Das, Ruchir Shah, Edwin van Beek, Sarim Ather, Howell Fu, Nabeeha Salik, Alan Campbell, Farhaan Khan, Abdala Trinidad Espinosa Morgado, Marusa Kotnik, Louise Wing, John Murchison, Jong Seok Ahn, Sang Hyup Lee, Ambika Seth

“…The study is currently ongoing with a planned end date of 31 December 2024.Ethics and dissemination The study has been approved by the UK Healthcare Research Authority. The use of anonymised retrospective CXRs has been authorised by Oxford University Hospital’s information governance teams. …”
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Clinical remission among severe asthmatics on monoclonal antibody therapy: real-world outcomes at 2 years by Fred Fyles, Rachel Burton, Amy Nuttall, Hannah Joplin, Laura Watkins, Hassan Burhan

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Recommendations for improving accessibility of digital health interventions for cardiometabolic disease for ethnically diverse populations by Mel Ramasawmy, Nushrat Khan, David Sunkersing, Madiha Sajid, Shivali H Modha, Manoj Mistry, Wasim Hanif, Fiona Stevenson, Kiran Patel, Kamlesh Khunti, Paramjit Gill, Lydia Poole, Amitava Banerjee

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The role of mesenchymal cells in cholangiocarcinoma by Mireia Sueca-Comes, Elena Cristina Rusu, Jennifer C. Ashworth, Pamela Collier, Catherine Probert, Alison Ritchie, Marian Meakin, Nigel P. Mongan, Isioma U. Egbuniwe, Jesper Bøje Andersen, David O. Bates, Anna M. Grabowska

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KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency by Samah W. Awwad, Colm Doyle, Josie Coulthard, Aldo S. Bader, Nadia Gueorguieva, Simon Lam, Vipul Gupta, Rimma Belotserkovskaya, Tuan-Anh Tran, Shankar Balasubramanian, Stephen P. Jackson

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Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study by Andrew Carson-Stevens, Maria Panagioti, Adrian Edwards, Jenny Shaw, Stephen Campbell, Carl de Wet, Kate Davies, Anthony Avery, Stuart Hellard, Melanie Jordan, Caroline Sanders, Isobel Joy McFadzean, Jane Senior, Darren M. Ashcroft, Caroline Stevenson, Tim Millar, Saied Ibrahim, Thomas Hewson, Sandra Flynn, Thomas Purchase, Florian Walter, Sioned Gwyn, Richard N. Keers, Ellie Thompson, Verity Wainwright

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Isolation of Burkholderia cepacia complex in adults with primary ciliary dyskinesia by Giulia Spoletini, Connie Webster, Nicola Burke, Emma Farrell, Evie Robson, Miles Denton, Daniel Peckham

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Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis by Peter M. George, Christian Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, Finja A. Ottink, Wassim Bou-Zeid, Roberta E. Ledda, Roqia F. Abul Kadir, Bushra Johari, Claire Fernandez, George W.J. Harston, Olivier Joly, Stephen Gerry, Anand Devaraj

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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

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Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…The aim of this qualitative research was to inform the design of the first adaptive platform trial for paediatric intensive care in the UK with young people, parents/carers and paediatric intensive care unit (PICU) staff.Design Qualitative semistructured focus group study. …”
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Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study by Simon Thom, Alice Stanton, Jamil Mayet, Amit Kaura, Darrel Francis, Anoop SV Shah, Andrew Sharp, Alun D Hughes, Neil R Poulter, Anenta Ratneswaren, Tong Wu, Somayeh Rostamian, Devan Wasan, PS Sever

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Comparison of different nebulisation systems for capsaicin cough challenge testing by Kimberley J. Holt, Joanne Mitchell, Rachel J. Dockry, Shilpi Sen, Jaclyn A. Smith

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