IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

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Dopamine agonists for restless legs syndrome  by Pran Phakdeekitcharoen, Michael J Keogh

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Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism by Hongbo Jiang, Xunling Wang, Yingwei Liang, Yinghan Hou, Xinping Yue, Zhiyi Zhang, Dan Chen, Xinyi Fan, Ailin Du

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Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L by Smith AB, Greenwood DC, Williams P, Kwon J, Petrou S, Horton M, Osborne T, Milne R, Sivan M

“…Adam B Smith,1 Darren C Greenwood,1,2 Paul Williams,3 Joseph Kwon,4 Stavros Petrou,4 Mike Horton,5 Thomas Osborne,5 Ruairidh Milne,6 Manoj Sivan5,7,8 On behalf of LOCOMOTION Consortium1Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, United Kingdom; 2Leeds Institute for Data Analytics, University of Leeds, Leeds, UK; 3COVID Assessment and Rehabilitation Service, Hertfordshire Community NHS Trust, Welwyn Garden City, UK; 4Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; 5Academic Department of Rehabilitation Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; 6Person with Long COVID; Public Health, University of Southampton, Southampton, UK; 7COVID Rehabilitation Service, Leeds Community Healthcare NHS Trust, Leeds, UK; 8National Demonstration Centre of Rehabilitation Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UKCorrespondence: Adam B Smith, Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, United Kingdom, Email a.b.smith@leeds.ac.ukBackground: Long COVID (LC) is a clinical syndrome with persistent, fluctuating symptoms subsequent to COVID-19 infection. …”
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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

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Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analys... by Catey Bunce, Gwyn Samuel Williams, David Owens, Wen Xing, Rhianon Reynolds, Antra Zekite, Declan Flanagan, RL Thomas, Rebecca John

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Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes by Yuanyuan Liu, Xueli Yang, Wei Zhou, Jinguo Yu, Song Chen, Tiangeng He, Caiyun You, Xiangda Meng, Mengyu Liao, Yi Lei, Hua Yan

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Health benefits of pedestrian and cyclist commuting: evidence from the Scottish Longitudinal Study by Paul Kelly, David Walsh, Bruce Whyte, Zhiqiang Feng, Chris Dibben, Graham Baker, Ruth Dundas, Evangelia Demou, Catherine Friel

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Multinational comparison of new antidepressant use in older adults: a cohort study by Robyn Tamblyn, David Westfall Bates, David L Buckeridge, Will Dixon, Alan J Forster, Nadyne Girard, Jennifer Haas, Bettina Habib, Siyana Kurteva, Jack Li, Therese Sheppard

“…Objectives We used an international pharmacosurveillance network to estimate the rate and characteristics of antidepressant use in older adults in countries with more conservative (UK) and liberal depression guidelines (Canada, USA).Setting Electronic health records and population-based administrative data from six jurisdictions in four countries (UK, Taiwan, USA and Canada).Participants A historical cohort of older adults (≥65 years) who had a new episode of antidepressant use between 2009 and 2014.Outcome measures The age and sex-standardised cumulative incidence of new episodes of antidepressant use in older adults was measured. …”
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Syrian refugee and diaspora healthcare professionals: Case studies from the eastern mediterranean and European regions by Aula Abbara, Munzer Alkhalil, Kinan Wihba, Omer Abdrabbuh, Diana Rayes, Andrew Ghobrial, Manar Marzouk, Fadi Halabi, Mahmoud Hariri, Abdulkarim Ekzayez

“…Results: We explore through case studies from countries near Syria (Turkey, Lebanon, Jordan, Egypt) and in Europe (Germany, UK) different policies which support or restrict entry into the health workforce. …”
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Renewable Energy Consumption and Economic Growth in Nine OECD Countries: Bounds Test Approach and Causality Analysis by Lin Hung-Pin

“…The co-integration and causal relationships are found in five countries—United States of America (USA), Japan, Germany, Italy, and United Kingdom (UK). The overall results indicate that (1) a short-run unidirectional causality runs from EG to RE in Italy and UK; (2) long-run unidirectional causalities run from RE to EG for Germany, Italy, and UK; (3) a long-run unidirectional causality runs from EG to RE in USA, and Japan; (4) both long-run and strong unidirectional causalities run from RE to EG for Germany and UK; and (5) Finally, both long-run and strong unidirectional causalities run from EG to RE in only USA. …”
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Uptake and 4-week outcomes of an ‘opt-out’ smoking cessation referral strategy in a London-based lung cancer screening setting by Anthony Edey, Neal Navani, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Tanya Patrick, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Samuel M Janes, Esther Arthur-Darkwa, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Geoff Bellingan, Nick Screaton, Priyam Verghese, William M Ricketts, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Andrew Crossingham, Tanita Limani, Kate Gowers, Andrew Perugia, James Rusius, Anne-Marie Hacker, Monica L Mullin, Evangelos Katsampouris, Chuen R Khaw, Chuen Khaw, Sheetal Karavadra, Alan Shaw, Chris Valerio, Ali Mohammed, Lynsey Gallagher, Mehran Azimbagirad, Burcu Ozaltin, Maureen Browne, Eleanor Hellier, Catherine Nestor

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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

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Comparative temporal response of toxicity for the neonicotinoid clothianidin and organophosphate dimethoate insecticides in two species of solitary bee (Osmia bicornis and Osmia co... by Helen Hesketh, Jan Baas, Elma Lahive, Alexander G. Robinson, David J. Spurgeon, Matthew S. Heard

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Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making by Oliver Härmson, Isaac Grennan, Brook Perry, Robert Toth, Colin G. McNamara, Timothy Denison, Hayriye Cagnan, Sanjay G. Manohar, Mark E. Walton, Andrew Sharott

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Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…The aim of this study was to establish a consensus on the thoughts and opinions related to refractory proctitis disease burden and best practice for management.Methods A three-round Delphi consensus survey was conducted among patients living with refractory proctitis and the healthcare experts with knowledge on this disease from the UK. A brainstorming stage involving a focus group where the participants came up with an initial list of statements was completed. …”
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One step further: improving paediatric TB diagnosis through user-centred research approaches by F.W. Basile, E.M. Bijker, M. Sekadde, S.E. Dorman, J.J. Ellner, N. Engel, M. Ruhwald, R. Song

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PMMB COVID-19 Bulletin: United Kingdom (22nd April 2020) by Loh Teng-Hern Tan, Vengadesh Letchumanan, Hooi-Leng Ser, Jodi Woan-Fei Law, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…Despite the lockdown is in place to slow the spread of COVID-19, UK death toll continues to surge. As of 21st April 2020, more than 120,000 confirmed COVID-19 cases and 16,000 deaths had been recorded in UK.…”
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Investigation of Uncoordinated Coexisting IEEE 802.15.4 Networks with Sleep Mode for Machine-to-Machine Communications by Chao Ma, Jianhua He, Zuoyin Tang, Wenyang Guan, Yue Li

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CEO Characteristics and Earnings Management: A Study of Manager Tenure, Age, Gender, and Overconfidence by Chen Sitao, Tzavara Dionisia, Argyropoulou Maria, Koufopoulos Dimitrios, Argyropoulou Rachel

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