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Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials
Published 2025-01-01“…Further head-to-head trials of tenecteplase and reteplase are needed to determine the optimal thrombolytic agent and dosing.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO CRD42024566146.…”
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Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging
Published 2025-02-01“…We utilized three datasets comprising 1372 female bilateral breast MRI exams from institutions in three countries: the United States (US), Switzerland, and the United Kingdom (UK) to train models. These models were then validated on two external datasets consisting of 649 bilateral breast MRI exams from Germany and Greece. …”
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Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study
Published 2025-01-01“…Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM2.5 and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods. …”
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Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins...
Published 2025-03-01“…Methods: We conducted population-based nested case–control studies of AD, PD, and ALS using electronic medical records in Europe (France, the UK, and Sweden) and Australia. We retrieved data on medication use, diagnosed health conditions, and measured blood biomarkers from electronic medical records or biomedical cohorts. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper
Published 2025-01-01“…Thus, the present project aimed to (i) test for syndemic interactions between social adversity (socioeconomic adversity and traumatic events) and mental, physical and oral multimorbidity using the syndemic theoretical framework; and (ii) determine whether the syndemic relationships vary by age, sex and ethnicity.MethodsData from three large-scale population-based databases: UK BioBank, US National Health and Nutrition Examination Survey (NHANES) and the Research with East London Adolescents Community Health Survey (RELACHS) will be analysed. …”
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Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model
Published 2025-02-01“…Methods We conducted a prospective cohort study that included 376,083 adults free of T2D and diabetes-related events at baseline in UK Biobank. PhenoAgeAccel > 0 and ≤ 0 were defined as biologically older and younger than chronological age. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition
Published 2025-02-01“…Methods: Data on in utero tobacco smoke exposure (IUTSE) status and age of tobacco use initiation from the UK Biobank were used to estimate early-life tobacco smoke exposure. …”
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Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])
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Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials
Published 2025-01-01“…However, further high-quality, multicenter randomized controlled trials are essential to confirm these findings and strengthen the evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024566739.…”
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A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023
Published 2025-02-01“…Among these publications, the USA, Spain, and UK emerged as the predominant contributing nations. …”
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Editorial
Published 2020-06-01“…The issue concludes with three book reviews focused on the pan-European context, the US context, and the UK context, respectively. Two are provocative reviews that identify the key merits of the books, and all three note just how complicated the intergenerational housing picture really is. …”
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