Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

“…Pharmacokinetic analysis revealed a dose‐related increase in LH011 and its metabolite WX‐UK1 exposure from 100 to 400 mg but not in the 600 mg group. …”
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Association of leukocyte telomere length with the risk of digestive diseases: A large-scale cohort study by Hongqun Yang, Lanlan Chen, Yahui Liu, Jinjiao Li

“…A cohort analysis of over 500,000 participants from the UK Biobank (UKB) between 2006 and 2021 was conducted to estimate the associations of LTL with more than 90 common digestive diseases. …”
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Effects of physical exercise on anxiety depression and emotion regulation in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis by Yagang Song, Shuqi Jia, Xing Wang, Aiwei Wang, Tao Ma, Shufan Li, Jiwei Chen, Zhaohui Guo, Feng Ding, Yuxi Ren, Man Qin

“…A dose-response relationship is evident, correlating with the type, duration, intensity, frequency, and overall exercise duration.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO identifier (CRD42024571577).…”
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Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography by Guruprasad P Aithal, Indra Neil Guha, Stephen D Ryder, Emilie A Wilkes, David J Harman, Martin W James, Matthew Jelpke, Dominic S Ottey, Timothy R Card

“…Objectives To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting.Design Prospective cross-sectional study.Setting Two primary care practices (adult patient population 10 479) in Nottingham, UK.Participants Adult patients (aged 18 years or over) fulfilling one or more selected risk factors for developing chronic liver disease: (1) hazardous alcohol use, (2) type 2 diabetes or (3) persistently elevated alanine aminotransferase (ALT) liver function enzyme with negative serology.Interventions A serial biomarker algorithm, using a simple blood-based marker (aspartate aminotransferase:ALT ratio for hazardous alcohol users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE).Main outcome measures Diagnosis of clinically significant liver disease (defined as liver stiffness ≥8 kPa); definitive diagnosis of liver cirrhosis.Results We identified 920 patients with the defined risk factors of whom 504 patients agreed to undergo investigation. …”
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Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial by Lauren Powell, Fiona O’Sullivan, Pramoda Jayasinghe, Basia Rogula, Feng Dai, Jessica Cirillo, Samantha Sweeney, Lucy Abraham, Jessica Ailani

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Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study by Hendrik Schulze-Koops, Tsutomu Takeuchi, Daniel Aletaha, Maya H Buch, Yoshiya Tanaka, Ricardo Blanco, Paul Emery, Jacques-Eric Gottenberg, Bernard G Combe, Roberto Caporali, Patrick Verschueren, Vijay Rajendran, Anna Zubrzycka-Sienkiewicz, Edmund V Ekoka Omoruyi, Francesco De Leonardis

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Autistic and transgender/gender diverse people’s experiences of health and healthcare by Kate Green, Elizabeth Weir, Lily Wright, Carrie Allison, Simon Baron-Cohen

“…As our sample was biased towards white individuals, UK residents, relatively highly educated individuals, those assigned female at birth, and those who currently identify as female, our findings may be less applicable to individuals of differing demographics. …”
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Geographic and socioeconomic variation of sodium and potassium intake in Italy: results from the MINISAL-GIRCSI programme by Simona Giampaoli, Francesco P Cappuccio, Chen Ji, Luigi Palmieri, Diego Vanuzzo, Chiara Donfrancesco, Renato Ippolito, Pasquale Strazzullo

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Breeding results for Echinacea purpurea (L.) Moench in Moscow Province by I. N. Korotkikh, E. Yu. Babaeva, A. E. Burova

“…Breeding accessions (Nos. 1-09, 2-09 and 22-09) were obtained by individual selection based on the biological collection of VILAR (Nos. 79, 80 and 38) received in 1998 from the UK (Exchange Seed Fund). Seeds were sown into plots (total area of 9.6 m2 ) with a 4-fold replication. …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…No life-threatening AEs were reported.ConclusionThe HAIC-L-P regimen correlated with enhanced tumor responses and prolonged survival, alongside manageable adverse effects, indicating its potential as a viable therapeutic strategy for individuals afflicted with uHCC.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024594109.…”
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Impact of subgingival periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome: a systematic review of randomized clinical trials by Marie Chavez, Asshly Ramirez, Akram Hernández-Vásquez, Daniel Comandé, Diego Azañedo

“…However, larger RCTs with standardized methods and longer follow-up are needed to confirm these results.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022366056, PROSPERO (CRD42022366056).…”
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Considerations for determining warm-water coral reef tipping points by P. Pearce-Kelly, A. H. Altieri, J. F. Bruno, C. E. Cornwall, M. McField, A. I. Muñiz-Castillo, J. Rocha, R. O. Setter, C. Sheppard, R. M. Roman-Cuesta, C. Yesson

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Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…Based on these findings, KATS will be further optimised before evaluating effectiveness in a randomised controlled trial.Trial registration number and protocol availability ISRCTN 13704805 https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/keeping-active-with-texting-after-stroke-kats/Protocol available https://www.isrctn.com/ISRCTN13704805?…”
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An analysis of controlled human infection studies registered on ClinicalTrials.gov by James Wilkinson, Joshua Osowicki, Euzebiusz Jamrozik, Ian J Saldanha, Meta Roestenberg, Danny Toomey, Jupiter Adams-Phipps, John Pietro, Jake Littman, Steffen Kamenicek, Daniel Kaufman

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Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis by Yuchen Wang, Yuchen Wang, Mengqi Li, Mengqi Li, Yuye Jiang, Yuye Jiang, Qiuhong Ji

“…To further validate the efficacy and safety of neuroprotective agents, future studies should involve larger sample sizes and conduct multicenter, large-scale randomized controlled trials.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=601346, identifier CRD42024601346.…”
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Impact of tele-exercise on quality of life, physical fitness, functional capacity and strength in different adult populations: a systematic review of clinical trials by Nuno Domingos Garrido, Nuno Domingos Garrido, Victor Machado Reis, Victor Machado Reis, José Manuel Vilaça-Alves, José Manuel Vilaça-Alves, Gabriela Chaves Lucas, Ismael Lima Godinho, Rafael Peixoto, Alberto Fucarino, Manuela Cantoia, Enzo Iuliano, Andrea De Giorgio, Antonio Fabbrizio, Martina Suasa, Giovanna Zimatore, Carlo Baldari, Filippo Macaluso

“…The review followed the PRISMA guidelines, ensuring a systematic approach to study selection, data extraction, and bias assessment.ResultsThe results indicate that tele-exercise, especially synchronous, has the potential to primarily improve physical fitness, functional capacity, and pain perception, being effective for the elderly and individuals with specific conditions such as multiple sclerosis and obesity.DiscussionHowever, the methodological heterogeneity of the studies and the lack of consistent data limit the generalisation of the findings, highlighting the need for more high-quality research.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024563241, PROSPERO (CRD42024563241).…”
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A case-matched series comparing functional outcomes for robotic-assisted unicompartmental knee arthroplasty versus functionally aligned robotic-assisted total knee arthroplasty by Jonathan R. Manara, Macdaniel Nixon, Beth Tippett, Wil Pretty, Dermot Collopy, Gavin W. Clark

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Healthy dietary patterns and the incidence of chronic kidney disease: results from a prospective cohort study by Yong-Ping Lu, Bin Xia, Xiao-Hua Wang, Qiang-Sheng He, Chang-Bo Qu, Ying-Ying Xie, Tian-Jiao Cui, Si-Qing Wu, Jin-Yu Zhao, Zhi-Hua Zheng, Ting Zhu, Jin-Qiu Yuan, Chun Tang

“…Abstract Background Unhealthy diets contribute to the onset and progression of chronic kidney disease (CKD), with poor dietary habits identified as significant lifestyle factors that elevate CKD risk. Methods Data from the UK Biobank cohort, which included over 500,000 participants aged 40–69 from diverse regions of England, Wales, and Scotland, were analyzed. …”
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Risk of diabetic ketoacidosis caused by sodium glucose cotransporter-2 inhibitors in patients with type 1 diabetes: a systematic review and network meta-analysis of randomized cont... by Ying Liu, Shiwen Yang, Aidou Jiang, Dan Zou, Zhaoyang Chen, Na Su, Na Su

“…However, SGLT2 inhibitors for treating T1DM are off label in China, and adverse reactions should be closely monitored during administration.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#loginpage, identifier CRD42023416227.…”
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Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants by Shujing Ma, Xue Liu, Ruilang Lin, Ye Yao, Min Zhao, Yongfu Yu, Costan G. Magnussen, Bo Xi

“…Methods A total of 180,527 participants from the UK Biobank aged 37 to 73 years were included. Associations of childhood body size or adulthood adiposity status as well as child–adult weight status change with incident adulthood hypertension were estimated by multivariate Cox proportional regression models. …”
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