Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case–control evidence from the British COVID Symptom Study Biobank by Hugo D Critchley, Dorina Cadar, Claire J Steves, Kevin A Davies, Alan J Hakim, Nicholas Gall, Jessica A Eccles, Vicky Bowyer, Lisa Quadt, Nathan Cheetham

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Feasibility study of a randomised controlled trial of preoperative and postoperative nutritional supplementation in major lung surgery by Amelia Swift, Sebastian T Lugg, Babu Naidu, Nikolaos Efstathiou, Amy Kerr, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Salma Kadiri, Ehab Bishay, Krishna Kholia, Venessa Rogers

“…The intervention involved preoperative carbohydrate-loading drinks (4×200 mL evening before surgery and 2×200 mL the morning of surgery) and early postoperative nutritional protein supplement drinks two times per day for 14 days compared with the control group receiving an equivalent volume of water.Setting Single adult thoracic centre in the UK.Participants All adult patients admitted for major lung surgery. …”
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The diagnostic accuracy of point-of-care nucleic acid-based isothermal amplification assays for scrub typhus: a systematic review and meta-analysis by Rashi Dixit, Sandeep Manikandan, John Antony Jude Prakash, Manisha Biswal, Dharitri Mohapatra, Natarajan Gopalan, G. Gnanamani, Sujit Kumar Behera

“…Active research and development focused on optimization of novel molecular diagnosis that are efficient, rapid, and cost-effective shall foster timely diagnosis and aid in reduction of the overall burden of scrub typhus.Protocol and registrationA detailed protocol of this review is registered and available in Prospero at: https://www.crd.york.ac.uk/prospero/. (registration number CRD42024511706).…”
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Microbial profile of burn wound injuries in the Northern West Bank − A retrospective cohort study by Sameh Natsha, Hester Lacey, Souad Belkebir, Ann Attili, Aya Atatra, Rawand Daragmeh, Anas Abu-Safa, Baljit Dheansa, Rasha Khayyat

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Technology usage and glycaemic outcomes in a single tertiary centre with an ethnically diverse and socioeconomically deprived cohort of children with type 1 diabetes mellitus by India Dickinson, Ankita Gupta, Gar Mun Lau, Pranav Viswanath Iyer, John Stuart Pemberton, Suma Uday, Suma Uday

“…BackgroundThe UK National Paediatric Diabetes Audit (NPDA) data reports disparities in Haemoglobin A1c (HbA1c) levels among children and young people (CYP) with Type 1 Diabetes (T1D), with higher levels in those of Black ethnic background and lower socioeconomic status who have less access to technology. …”
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Supramolecular Organic Framework with Multidimensional Storage Spaces for Ultrahigh-Capacity Iodine Capture from Seawater by Lijuan Feng, Jun Zhang, Jiacheng Zhang, Xuewen Cao, Zhanhu Guo, Yihui Yuan, Ning Wang

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Assessment of ante mortem welfare indicators and the pathophysiology of captive-bolt trauma in equids at slaughter by Katharine A Fletcher, Barbara Padalino, Martina Felici, Daniele Bigi, Georgina Limon-Vega, Andrew Grist, Troy J Gibson

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Ground-based contrail observations: comparisons with reanalysis weather data and contrail model simulations by J. Low, R. Teoh, J. Ponsonby, E. Gryspeerdt, M. Shapiro, M. E. J. Stettler

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Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis by Xinyue Yang, Lin Zhang, Jing Yu, Meng Wang

“…Caution is needed in interpreting our results, and high-quality RCTs are urgently required for more reliable insights.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, identifier CRD42024432912.…”
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Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development by Baranasic Jurica, Niazi Yasmeen, Chattopadhyay Subhayan, Rumora Lada, Ćorak Lorna, Dugac Andrea Vukić, Jakopović Marko, Samaržija Miroslav, Försti Asta, Knežević Jelena

“…We extracted summary data of variants in 1511 immune-related genes from COPD and LC genome-wide association studies (GWAS) from the UK Biobank. The LC data had 203 cases, patients diagnosed with LC, and 360 938 controls, while COPD data had 1 897 cases and 359 297 controls. …”
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High-performance UWB Vivaldi antenna on FR4: A cost-effective solution for wearable technologies by Sahar Saleh, Tale Saeidi, Nick Timmons, Bader Alali, Faroq Razzaz, Ayman A. Althuwayb

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Sex-specific differences in children attending the emergency department: prospective observational study by Joany M Zachariasse, Henriette A Moll, Ian K Maconochie, Ewout W Steyerberg, Daan Nieboer, Dorine M Borensztajn, Claudio F Alves, Frank J Smit, Susanne Greber-Platzer, Claudia M G Keyzer-Dekker

“…Objective To assess the role of sex in the presentation and management of children attending the emergency department (ED).Design The TrIAGE project (TRiage Improvements Across General Emergency departments), a prospective observational study based on curated electronic health record data.Setting Five diverse European hospitals in four countries (Austria, The Netherlands, Portugal, UK).Participants All consecutive paediatric ED visits of children under the age of 16 during the study period (8–36 months between 2012 and 2015).Main outcome measures The association between sex (male of female) and diagnostic tests and disease management in general paediatric ED visits and in subgroups presenting with trauma or musculoskeletal, gastrointestinal and respiratory problems and fever. …”
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A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair by Shan An, Claudio Intini, Donagh O'Shea, James E. Dixon, Yiran Zheng, Fergal J. O'Brien

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Sickness absence trajectories among young employees in their first full-time employment and subsequent long-term sickness absence: a Danish register-based cohort study by Naja Hulvej Rod, Tea Lallukka, Ida Madsen, Ute Bültmann, Maria Melchior, Reiner Rugulies, Jacob Pedersen, Stephen Stansfeld, Jeppe Karl Sørensen, Karl Bang Christensen, Jimmi Mathisen

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Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…We collected data through desk reviews, stakeholder interviews and focus group discussions with stakeholders from government, academia and civil society from six purposefully selected countries: Nigeria, Singapore, South Africa, Bangladesh, Jordan and the UK.Results Regardless of political, geographic and economic context, all six countries adopted common strategies to make decisions under three types of uncertainties. …”
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Humanizing processes after harm part 1: patient safety incident investigations, litigation and the experiences of those affected by Lauren Ramsey, Laura Sheard, Justin Waring, Siobhan McHugh, Ruth Simms-Ellis, Ruth Simms-Ellis, Gemma Louch, Katherine Ludwin, Jane K. O’Hara

“…Nonetheless, there remains little UK-based evidence exploring how this relates to the experiences of those affected over time, including the factors influencing decisions to litigate.AimsWe aimed to explore the experiences of patients, families, staff and legal representatives affected by safety incidents over time, and the factors influencing decisions to litigate.MethodsParticipants were purposively recruited via (i) communication from four NHS hospital Trusts or an independent national investigator in England, (ii) relevant charitable organizations, (iii) social media, and (iv) word of mouth to take part in a qualitative semi-structured interview study. …”
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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

“…In this study, we acquired 731 immune cell phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data from the research by Handan Melike Dönertaş et al. (3,731 cases, 480,867 controls), and aggregated statistics of 1,400 blood metabolites from UK Biobank (n = 115,078). Bidirectional MR analysis was performed to explore the causal relationships between the immune cell phenotypes and HD, and two-sample and multi-variable MR were conducted to identify the potential plasma metabolites mediating in HD. …”
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Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries: Protocol for a Systematic Review and Meta-Analysis by Maria Beatriz Mourato, Nuno Pratas, Andreia Branco Pereira, Filipa Taré, Raphael Chança, Inês Fronteira, Rui Dinis, Miguel Areia

“…Trial RegistrationPROSPERO CRD42024502174; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=502174 International Registered Report Identifier (IRRID)DERR1-10.2196/56791…”
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A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study by Ian D Cameron, Ilaria Pozzato, Ashley Craig, Bamini Gopinath, Mark Gillett, Annette Kifley, Kim Van Vu, Susanne Meares, Anthony Liang

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Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease by Shuo Zhang, Yuxin Liu, Jike Qi, Yu Yan, Tongyu Gao, Xin Zhang, Dong Sun, Ting Wang, Ping Zeng

“…Methods: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM2.5, PM10, PM2.5–10, NO2 and NOx, and the incidence of CKD by calculating an air pollution score. …”
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