Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

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Effect of perioperative esketamine use on emergency delirium in children undergoing tonsillectomy and adenoidectomy: a systematic review and meta-analysis of randomized controlled... by Junfeng Liu, Jinming Liu, Hong Sun, Xue Cheng, Chunhui Wang, Daoyun Lei, Chao Han

“…However, the optimal dose and timing of esketamine administration for preventing ED remains to be explored.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=558560, PROSPERO: CRD42024558560.…”
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Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabet... by Mohsin Azam, Lindsey Marwood, Khalida Ismail, Tyrrell Evans, Sobha Sivaprasad, Kirsty Winkley, Stephanie Anne Amiel

“…WHO’s recommendation of HbA1c≥48 mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. …”
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Shaping Treatment Expectation to Optimize Efficacy of Interleukin 17A Antagonist Secukinumab in Psoriasis Patients by Hölsken S, Krefting F, Mühlhaus S, Bese D, Schedlowski M, Sondermann W

“…Stefanie Hölsken,1 Frederik Krefting,2 Senta Mühlhaus,2 Daniela Bese,2 Manfred Schedlowski,1,3 Wiebke Sondermann2 1Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 2Department of Dermatology, Venereology and Allergology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 3Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, 171 77, SwedenCorrespondence: Stefanie Hölsken, Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Hufelandstraße 55, Essen, 45147, Germany, Email Stefanie.Hoelsken@uk-essen.dePurpose: Patients’ treatment expectations significantly influence the effectiveness of medical and pharmacological treatments. …”
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Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety by Víctor Mayoral, Rafael Galvez, Marta Ferrándiz, Xoán Miguéns Vázquez, Carlos Cordero-García, Antonio Alcántara Montero, Concepción Pérez, María Pérez-Páramo

“…Additionally, it improved patient-reported outcomes, resulted in lower opioid consumption, and led to fewer adverse events.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=565208, PROSPERO (CRD42024565208).…”
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Call for Papers: Intergenerational Justice Prize 2020 by FRFG, IF (Foundation for the Rights of Future Generations, Intergenerational Foundation)

“…For full entry requirements (details of required formatting, addresses for submissions etc, and an official entry form) email Maria Lenk (kontakt@srzg.de) or Antony Mason (awards@if.org.uk). Closing date for prize submissions: 1 July 2020, 23:59 (GMT+1) …”
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Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

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Association of iron status indicators with thyroid hormone concentrations during pregnancy: a systematic review and meta-analysis by Mohammadamin Parsaei, Mohadese Dashtkoohi, Elahe Amirkhalili, Mohammadreza Chashmyazdan, Tim I. M. Korevaar, Tim I. M. Korevaar, Pantea Nazeri

“…This suggests that monitoring hemoglobin could enhance the early detection and management of thyroid dysfunction during pregnancy.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD4202451820.…”
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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

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Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis by Paik B, Chua CH, Yip LW, Yip VC

“…Benjamin Paik,1 Chun Hau Chua,2 Leonard W Yip,1,2 Vivien CH Yip1,2 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, SingaporeCorrespondence: Vivien CH Yip, TTSH Medical Centre, 11 Jalan Tan Tock Seng, Level 1, Singapore, 308433, Singapore, Email vyip82@yahoo.co.ukTopic: To analyse the safety and efficacy of minimally invasive glaucoma surgeries (MIGS) in lowering IOP and medication burden in primary angle closure (PAC) or primary angle closure glaucoma (PACG).Clinical Relevance: MIGS is off-label in angle closure, as implantation of the device is difficult when there is iridotrabecular contact. …”
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Physicians’, pharmacists’, and nurses’ education of patients about antibiotic use and antimicrobial resistance in primary care settings: a qualitative systematic literature review... by Lavinia Bianca Balea, Ragnhild J. A. Gulestø, Hongxuan Xu, Hongxuan Xu, Stinne Glasdam

“…Addressing gaps in education on antibiotic use and AMR requires acknowledging these multifaceted challenges, with future efforts focusing on better supporting healthcare professionals in this context.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD4202455761.…”
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Efficacy of electroacupuncture for insomnia in cancer patients: a systematic review and meta-analysis by Xiaodong Liu, Ning Xu, Shangpei Wang, Qingjun Jia

“…However, additional high-quality studies are necessary to validate these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=567567, Identifier CRD42024567567.…”
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Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Summary statistics for plasma proteins were obtained from genome-wide association studies performed using SomaLogic (N = 35,559; deCODE) and Olink (N = 34,557; UK Biobank; UKB) proteomic platforms and for MM risk from a meta-analysis of UKB and FinnGen (case = 1649; control = 727,247) or FinnGen only (case = 1085; control = 271,463). …”
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Machine learning for the diagnosis accuracy of bipolar disorder: a systematic review and meta-analysis by Yi Pan, Pushi Wang, Bowen Xue, Yanbin Liu, Xinhua Shen, Shiliang Wang, Xing Wang

“…Therefore, in future studies, we anticipate the development of more multi-class classification tasks to enhance the clinical applicability of these methods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023427290, identifier CRD42023427290.…”
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Measurement report: The ice-nucleating activity of lichen sampled in a northern European boreal forest by U. Proske, U. Proske, U. Proske, M. P. Adams, G. C. E. Porter, M. A. Holden, M. A. Holden, J. Bäck, B. J. Murray

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Serum Levels of Epithelial-Derived Cytokines as Interleukin-25 and Thymic Stromal Lymphopoietin after a Single Dose of Mepolizumab in Patients with Severe Non-Allergic Eosinophilic... by Virginija Kalinauskaite-Zukauske, Andrius Januskevicius, Ieva Janulaityte, Skaidrius Miliauskas, Kestutis Malakauskas

“…The fractional exhaled nitric oxide (FeNO) level was analysed using an electrochemical assay (NIOX VERO®, Circassia, UK). Serum IL-25 and TSLP levels were measured by ELISA. …”
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A systematic review on gut microbiota in type 2 diabetes mellitus by Serena Chong, Serena Chong, Mike Lin, Mike Lin, Deborah Chong, Slade Jensen, Slade Jensen, Slade Jensen, Namson S. Lau, Namson S. Lau, Namson S. Lau

“…Future research should incorporate age, diet and medication-matched controls, and include functional analysis of these gut microbes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023459937.…”
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Dorsal cortex line is more reliable than transepicondylar axis for rotation in revision total knee arthroplasty with severe bone loss by Mikhail Salzmann, Ellen Kropp, Robert Prill, Nikolai Ramadanov, Marco Adriani, Roland Becker

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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment by Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun

“…Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.MethodsThe publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively. We first conducted a bidirectional two-sample Mendelian randomization (MR) analysis to examine the susceptibility of insulin resistance on cognitive phenotypes. …”
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Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis by Fenfang Wu, Chunhua Xu, Xinlei Si, Fei He, Kang Xu, Yu Zhang, Shan Lin

“…It may improve the function of glomeruli and tubules, promote the recovery of tubular function, and thus enhance the clinical therapeutic effects.Systematic review registrationwww.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42024559042.…”
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