Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis by Huang P, Zhao Y, Wei H, Wu W, Guo Z, Ma S, Xu M, Wang Q, Jia C, Xiang T, Li H

“…Additionally, extensive UK Biobank data pertaining to blood lipid profiles within European cohorts included measurements for low-density lipoprotein cholesterol (LDL-C) with 440,546 individuals, high-density lipoprotein cholesterol (HDL-C) with 403,943 individuals, triglycerides (TG) with 441,016 individuals, total cholesterol (TC) with 187,365 individuals, apolipoprotein A-I (apoA-I) with 393,193 individuals, and apolipoprotein B (apoB) with 439,214 individuals. …”
Get full text

Ursodeoxycholic Acid at 18–22 mg/kg/d Showed a Promising Capacity for Treating Refractory Primary Biliary Cholangitis by Xinyu Xiang, Xiaoli Yang, Mengyi Shen, Chen Huang, Yifeng Liu, Xiaoli Fan, Li Yang

“…Additionally, the risk score predicted by the UK-PBC model was lower in high-dosage UDCA-treated patients than in the standard dosage group (all P<0.05). …”
Get full text

How have interventions targeting pregnant women from refugee, migrant and culturally and linguistically diverse backgrounds living in high-income countries been developed or tailor... by Sweekriti Sharma, Gayathri Jegadeesh, Camille Raynes-Greenow, Adrienne Gordon, Gayani Gunawardhana, Danielle Marie Muscat

“…Studies were conducted in Australia, the UK, US and Denmark between 1986 and 2021, with multi-ethnic populations (n = 6) or specific cultural and language groups (n = 3) (e.g. …”
Get full text

Cohort profile: Anhui Maternal–Child Health Study in China by Yunxia Cao, Ruoling Chen, Weiju Zhou, Xiaofeng Xu, Xiaoqing Peng, Jiaqian Yin, Chunmei Liang, Ranjit Khutan, Fang-Biao Tao

Get full text

Palaeoproteomic identification of a whale bone tool from Bronze Age Heiloo, the Netherlands by Dekker, Joannes A. A., Mylopotamitaki, Dorothea, Verbaas, Annemieke, Sinet-Mathiot, Virginie, Presslee, Samantha, McCarthy, Morgan L., Olsen, Morten Tange, Olsen, Jesper V., van den Hurk, Youri, Brattinga, Joris, Welker, Frido

Get full text

Awareness of lung cancer among urban residents in Sichuan Province and its impact on their willingness to choose medical institutions for cancer screening by Qi Chai, Ruicen Li, Ting Bao, Zhibo Yang, Qing Liu, Feng Chen

“…Only 33.5% of the participants had undergone lung cancer screening, with the main reasons being periodic physical examinations (54%) and physician recommendations (23%). (2) Binary logistic regression analysis revealed that knowledge of lung cancer was significantly associated with the participants’ willingness to undergo lung cancer screening at county-level or lower-level medical institutions [OR = 1.185, 95% CI (1.113 -1.263), p &lt; 0.001]. (3) Using PSM, it was found that the willingness of residents who had good knowledge of lung cancer-related topics increased by 2.8% after using kernel matching, by 3.1% after using one-to-one nearest neighbor matching, and by 2.4% after using radius matching with a caliper size of 0.001. (4) After stratifying by psychological status, we found that among residents with unstable psychological status, the willingness of those who had good knowledge of lung cancer increased by 5.3% after using kernel matching, by 3.6% after using one-to-one nearest neighbor matching, and by 4.9% after using radius matching with a caliper size of 0.001.DiscussionImproving urban residents’ understanding of the disease could help improve the current situation of hierarchical diagnosis and treatment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024556625.…”
Get full text

Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis by Jiapeng Jing, Jiapeng Jing, Qinzhi Zheng, Qinzhi Zheng, Hongfei Dong, Yan Wang, Peiji Wang, Di Fan, Zhuo Xu

“…It is necessary to formulate reasonable exercise programs according to the characteristics of different demographic groups.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024555514.…”
Get full text

Systematic review and bayesian network meta-analysis: comparative efficacy and safety of six commonly used biologic therapies for moderate-to-severe Crohn’s disease by Haohang Su, Haohang Su, Shengwei Xiao, Zhiqing Liang, Zhiqing Liang, Tianrong Xun, Jinfang Zhang, Jinfang Zhang, Xixiao Yang, Xixiao Yang

“…Adalimumab and the 10 mg/kg regimen of Infliximab have maintenance efficacy benefits for responders to induction therapy.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=458609, Identifier CRD42023458609.…”
Get full text

Participation in a pre-registration student interprofessional education (IPE) society: influence on subsequent professional practice by Christine Hirsch, Emily Audet, Emily Audet, Ekrahh Dawood, Freya Beardmore, Nafeesa Hussain, Wing Chi Wong, Robert J. Barry, Sharon Buckley

“…Resulting themes were reviewed for relevance to the University of Birmingham (UK) IPE Framework, which uses the competency domains of the Canadian Interprofessional Health Collaborative Competency Framework as the required learning outcomes for IPE at Birmingham.ResultsEight interviews with former KASE members were conducted between November 2022 and March 2023. …”
Get full text

Changes in glycosphingolipid levels in plasma and cerebrospinal fluid of individuals with Lysosomal Free Sialic Acid Storage Disorder by Marya S. Sabir, Lynne Wolfe, David R. Adams, Carla Ciccone, Forbes D. Porter, William A. Gahl, Marjan Huizing, Frances M. Platt, May Christine V. Malicdan

Get full text

Development and Validation of the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS) by Leng J, Cai H, Liu F, Shi X, Fan Z

“…Jiaqi Leng,1 Huilin Cai,1 Fei Liu,2 Xiaoli Shi,3 Zhiguang Fan4 1School of English, Jilin International Studies University, Changchun, 130117, People’s Republic of China; 2Section of Student Affair, ChangChun Vocational School of Technology, Changchun, 130117, People’s Republic of China; 3Department of Psychology, University of Exeter, Exeter, EX4 4 QG, UK; 4Department of Psychology, Shaoxing University, Shaoxing, 312000, People’s Republic of ChinaCorrespondence: Zhiguang Fan, Department of Psychology, Shaoxing University, Shaoxing, 312000, People’s Republic of China, Tel +86-0431-84924101, Fax +86 1 594-831-4623, Email fanyqm@126.comBackground: Stigma can not only threaten the self-identity of secondary vocational students, but also have negative effects on their mental health and behavior.Objective: This study aimed to develop the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS) and test its reliability and validity.Patients and Methods: This study formed a scale based on the stigma conceptualization model and open questionnaire. …”
Get full text

Assessing the impact of sewage and wastewater on antimicrobial resistance in nearshore Antarctic biofilms and sediments by Melody S Clark, Benjamin H Gregson, Carla Greco, Harisree Paramel Nair, Marlon Clark, Claire Evans, Kevin A. Hughes, Kudzai Hwengwere, Marcus Leung, Lloyd S Peck, Caray A. Walker, William Chow

“…This study takes a sequencing discovery-led approach to investigate levels and extent of AMR around the Rothera Research Station (operated by the UK) on the Antarctic Peninsula. Results Amplicon sequencing of biofilms and sediments from the vicinity of Rothera Research Station revealed highly variable and diverse microbial communities. …”
Get full text

Ethnic disparities in HbA1c and hypoglycemia among youth with type 1 diabetes: beyond access to technology, social deprivation and mean blood glucose by Suma Uday, John Stuart Pemberton, Zhide Fang, Stuart A Chalew

“…Introduction The UK national pediatric diabetes audit reports higher HbA1c for children and young people (CYP) with type 1 diabetes (T1D) of Black ethnicity compared with White counterparts. …”
Get full text

New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

Get full text

Changes in the shape of the lumbar curve during growth: a geometric morphometric approach by Ruth Pelleg-Kallevag, Sarah Borgel, Einat Kedar, Nathan Peled, Hila May

Get full text

Occurrence and management of thrombosis recurrence and bleeding in low-molecular-weight heparin-treated patients with cancer-associated thrombosis: a French nationwide cohort study by Isabelle Mahé, Gaelle Gusto, Nadia Quignot, Artak Khachatryan, Jose Chaves, Audrey Moniot, Lucas Andre, Sylvain Van Roy, Ruth Mokgokong, Laurent Bertoletti

Get full text

Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials by Yang Fang, Yang Fang, Bai Xiaoling, Li Huan, Li Huan, Guan Yaping, Zhang Binying, Wang Man, Wu Juan, Liu Xinyu

“…No notable disparities were noted in the effects of exercise duration or patient age on depression outcomes between the subgroups (p = 0.86, p = 0.48).ConclusionExercise interventions that exhibit high adherence to the ACSM guidelines prove to be more efficacious in alleviating depression among hemodialysis patients as compared to those with low or uncertain adherence levels.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero…”
Get full text

Early Intervention for Children With Developmental Disabilities and Their Families via Telehealth: Systematic Review by Yoomi Shin, Eun Ju Park, Anna Lee

“…Trial RegistrationPROSPERO CRD42024551286; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=551286…”
Get full text

Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=470268, identifier CRD42024470268.…”
Get full text

Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study by Danielle van der Windt, Milada Cvancarova Småstuen, Kjersti Storheim, Margreth Grotle, Zinajda Zolic-Karlsson, Ørjan Nesse Vigdal, Rikke Munk Killingmo, Lise Kretz

Get full text