Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…We performed a bidirectional Mendelian randomization and mediation study based on randomly allocated instrumental variables to infer causality, followed by external validation with UK Biobank data and Bayesian colocalization. Results We demonstrated that an elevated level of CD27 on IgD + CD24 + B cell, a subset of B cells expressing both IgD and CD24, was associated with a higher risk of SS (OR = 1.119, 95% CI: 1.061–1.179, P < 0.001), while CD3 on CD45RA + CD4 + Treg was a protective factor (OR = 0.917, 95%CI: 0.877–0.959, P < 0.001). …”
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Inequalities in colorectal cancer diagnosis by ethnic group: a population-level study in the English National Health Service by Amy Downing, Mo Thoufeeq, James Turvill, Eva J A Morris, Phil Quirke, John C Taylor, Rebecca J Birch, Nick E Burr

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Patients’ and caregivers’ perspectives on access to kidney replacement therapy in rural communities: systematic review of qualitative studies by Allison Tong, Stephen May, Jonathan Craig, Martin Howell, Talia Gutman, Rachel Chalmers, David J Tunnicliffe, Nicole Jane Scholes-Robertson, Amanda Baumgart, Victoria SInka

“…This study aims to describe the perspectives of patients and caregivers on access to KRT in rural communities to inform strategies to maximise access to quality care, and thereby reduce disadvantage, inequity and improve health outcomes.Setting 18 studies (n=593 participants) conducted across eight countries (Australia, Canada, the UK, New Zealand, Ghana, the USA, Tanzania and India).Results We identified five themes: uncertainty in navigating healthcare services (with subthemes of struggling to absorb information, without familiarity and exposure to options, grieving former roles and yearning for cultural safety); fearing separation from family and home (anguish of homesickness, unable to fulfil family roles and preserving sense of belonging in community); intense burden of travel and cost (poverty of time, exposure to risks and hazards, and taking a financial toll); making life-changing sacrifices; guilt and worry in receiving care (shame in taking resources from others, harbouring concerns for living donor, and coping and managing in isolation).Conclusion Patients with CKD in rural areas face profound and inequitable challenges of displacement, financial burden and separation from family in accessing KRT, which can have severe consequences on their well-being and outcomes. …”
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Using machine learning models to plan HIV services: Emerging opportunities in design, implementation and evaluation by T Dzinamarira, E Mbunge, I Chingombe, D F Cuadros, E Moyo, I Chitungo, G Murewanhema, B Muchemwa, G Rwibasira, O Mugurungi, G Musuka, H Herrera

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The efficacy and safety of CD7 chimeric antigen receptor T-cell therapy for hematologic malignancies: a systematic review and meta-analysis by Jile Liu, Yuxin An, Rui Sun, Xiaomei Zhang, Shujing Guo, Xuejin Gao, Mingfeng Zhao

“…This suggests that gene edited CD7 CAR-T cells may pose some potential risks that limit the long-term survival of patients.ConclusionOur study confirms the efficacy and safety of CD7 CAR-T cells and provides research directions for the subsequent treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=502896, identifier CRD42024502896.…”
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Inequalities in children’s tooth decay requiring dental extraction under general anaesthetic: a longitudinal study using linked electronic health records by Carol Dezateux, Nicola Firman, Vanessa Muirhead

“…We investigated inequalities in DGA in an ethnically diverse, disadvantaged school-age population and associations of DGA with prior excess weight.Methods We identified 608 278 children aged 5–16 years in 2017–2022 from linked hospital and primary care electronic health records (EHRs) for a London, UK region. We estimated ORs (95% CI) for DGA, adjusting for sex, ethnicity, locality and deprivation. …”
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Public health economic modelling in evaluations of salt and/or alcohol policies: a systematic scoping review by Joseph Prince Mensah, Chloe Thomas, Robert Akparibo, Alan Brennan

“…The included studies evaluated alcohol and/or salt interventions in a combined total of 64 countries. Policies from the UK (23%) and Australia (18%) were the most frequently evaluated. …”
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Spatial identification of regions exposed to multi-hazards at the pan-European level by T.-E. Antofie, T.-E. Antofie, S. Luoni, A. Tilloy, A. Sibilia, S. Salari, G. Eklund, D. Rodomonti, C. Bountzouklis, C. Corbane

“…Based on the RDH data, we propose a methodology for the identification of regions with multi-hazard exposure at the pan-European level (EU27+UK). This methodology aims to support disaster risk management (DRM) decision-making processes at both national and subnational levels in the EU. …”
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Feasibility of implementing a rapid-learning methodology to inform radiotherapy treatments: key professional stakeholders’ views by Corinne Faivre-Finn, Kevin Franks, Fiona McDonald, David P French, Daniel Johnson, Arbaz Kapadi, Gareth Price, Rebecca Holley, Kate Wicks, Kathryn Banfill, Gareth Webster

“…This study investigated key professional stakeholders’ perceptions and opinions of rapid-learning and real-world data (RWD).Methods and analysis Twenty-three interviews were conducted with key professional stakeholders based across five UK radiotherapy cancer centres. Centres varied in size and reflected different healthcare environments. …”
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Describing randomization in trials included in systematic reviews in orthopaedic surgery by Matthew Tang, Kimberley K. Lun, Adriane M. Lewin, Ian A. Harris

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Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

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Can real-time surveillance systems of suspected suicide accurately reflect national suicide rates? Age-specific and sex-specific findings from the first two years of the COVID-19 p... by Nav Kapur, Louis Appleby, Pauline Turnbull, Su-Gwan Tham, Saied Ibrahim, Cathryn Rodway

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Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? by Qi Chen, Yifei Gao, Yunhui Tang, Luling Lin, Mingzhi Zhao, George Qiaoqi Chen, Shouzhen Chen

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Revize vzdělávacího obsahu bezpečnostní problematiky pohledem klíčových aktérů kurikulární reformy by Miroslava Kovaříková

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Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthe... by Emily Eisner, Sophie Faulkner, Stephanie Allan, Hannah Ball, Daniela Di Basilio, Jennifer Nicholas, Aansha Priyam, Paul Wilson, Xiaolong Zhang, Sandra Bucci

“…Trial RegistrationPROSPERO CRD42021282871; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871…”
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Deaths in children in England from SARS-CoV-2 infection during the first 2 years of the pandemic: a cohort study by Shamez N Ladhani, Peter Fleming, Tom Williams, Karen Luyt, Godwin Oligbu, David Odd, Sylvia Stoianova, Anna Thursby-Pelham

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Genomic Insights Into Red Squirrels in Scotland Reveal Loss of Heterozygosity Associated With Extreme Founder Effects by Melissa M. Marr, Emily Humble, Peter W. W. Lurz, Liam A. Wilson, Elspeth Milne, Katie M. Beckmann, Jeffrey Schoenebeck, Uva‐Yu‐Yan Fung, Andrew C. Kitchener, Kenny Kortland, Colin Edwards, Rob Ogden

“…., 1758), is endangered in the UK. Scotland represents a key stronghold, but Scottish populations have been subjected to intense anthropogenic influence, including widespread extirpations, reintroductions and competition from an invasive species. …”
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What about the donor site morbidity – how invasive is the free latissimus dorsi flap? by Nikolaus Wachtel, Riccardo E. Giunta, Marc Hellweg, Maximilian Hirschmann, Constanze Kuhlmann, Nicholas Moellhoff, Denis Ehrl

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Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study by Sweta Pathak, Tom G. Richardson, Eleanor Sanderson, Bjørn Olav Åsvold, Laxmi Bhatta, Ben M. Brumpton

“…We used summary statistics from a genome-wide association study (GWAS) of UK Biobank (n = 453,169) and large-scale consortia of anxiety (Million Veteran Program) and depression (Psychiatric Genomics Consortium) (n = 175,163 and n = 173,005, respectively). …”
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The Cost-effectiveness of Celecoxib versus Non-steroidal Anti-inflammatory Drugs plus Proton-pump Inhibitors for Treating Osteoarthritis in Algeria by Nadir Hammoumraoui, Sid Ahmed Kherraf, Joaquin Mould-Quevedo, Tarek A. Ismail

“…**Methods:** The National Institute for Health and Clinical Excellence (NICE) health economic model from UK, updated with relative risks of adverse events using CONDOR trial data, was adapted for costeffectiveness analysis in OA patients aged ≥65 years. …”
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