Downsystem grain-size trends and mass balance of an ancient wave-influenced sediment routing system: Middle Jurassic Brent Delta, northern North Sea, offshore UK and Norway by Ikenna C. Okwara, Gary J. Hampson, Alexander C. Whittaker, Gareth G. Roberts

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Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred randomised controlled trial, a UK qualitative study by Michael Skovdal Rathleff, Phillipa Logan, Marcus Bateman, Benjamin E Smith, Fiona Moffatt, Paul Hendrick, James Selfe, Toby O Smith

“…The trial investigated a loaded self-managed exercise intervention, which included education and advice on physical activity versus usual physiotherapy as the control.Design Qualitative study, embedded within a mixed-methods design, using semi-structured interviews.Setting A UK National Health Service physiotherapy clinic in a large teaching hospital.Participants Purposively sampled 20 participants within a feasibility RCT study; 10 patients with a diagnosis of patellofemoral pain, aged between 18 and 40 years, and 10 physiotherapists delivering the interventions.Results In respect to barriers and facilitators, the five overlapping themes that emerged from the data were: (1) locus of control; (2) belief and attitude to pain; (3) treatment expectations and preference; (4) participants’ engagement with the loaded self-managed exercises and (5) physiotherapists’ clinical development. …”
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Exploring the experiences of minoritised groups at life sciences conferences in the UK: new perspectives and actions to improve inclusivity in the sector [version 3; peer review: 1 approved, 2 approved with reservations] by Tinu Cornish, Hayley Clissold, Ashlee Christoffersen, Janice Prentice, Kathlyn Wilson, Victor Penda, Ireena Dutta, Julian C. Rayner, Michelle Bishop, Saher Ahmed, Treasa Creavin

“…Attending and participating in scientific research meetings and conferences is a key mechanism for researchers to share information and knowledge, build networks, and establish relationships and collaborations to support career development. In the UK, researchers from minoritised or underrepresented groups may have a different experience at a conference than their peers. …”
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Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–control analyses from UK primary care by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). …”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in the UK biobank by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…The present study was conducted to explore how single-nucleotide polymorphism (SNP) impacts the development of fibrosis in those suffering from NAFLD.Materials and methods Utilizing the UK Biobank dataset, we conducted a nested case-control analysis among NAFLD participants, defining the case group as those with liver fibrosis and cirrhosis during follow-up. …”
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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

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Planning for the unexpected: Exploring the 2024 Global IT Outage (GITO) impact on critical infrastructures by Jaime Santos-Reyes

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Airborne Transmission of the SARS-CoV-2 Delta Variant and the SARS-CoV-2 Omicron Variant by Byung Uk Lee

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Mediation of the effect of prenatal maternal smoking on time to natural menopause in daughters by birthweight-for-gestational-age z-score and breastfeeding duration: analysis of two UK birth cohorts born in 1958 and 1970 by Darina Peycheva, Leah Li, Mary Fewtrell, Richard Silverwood, Rebecca Hardy

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Two managerial public relations roles in the South African context by Benita Steyn, Tery Everett

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Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes by Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

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Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic biomarkers: an analysis of the UK Biobank cohortResearch in context by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Findings: Of the total 23,856 patients with T2DM in the UK Biobank, 13,706 participants (61% males) were eligible and included in this study. …”
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Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III trial by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

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The development of a food-group, tree classification method and its use in exploring dietary associations with metabolic dysfunction-associated Steatotic liver disease (MASLD) and other health-related outcomes in a UK population by Amina A. Alawadi, Amrita Vijay, Jane I. Grove, Moira A. Taylor, Guruprasad P. Aithal

“…Background: Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects up to one in five people in the UK, with persistent overeating and a sedentary lifestyle being significant risk factors. …”
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Evaluation of the diagnostic accuracy of two point-of-care tests for COVID-19 when used in symptomatic patients in community settings in the UK primary care COVID diagnostic accuracy platform trial (RAPTOR-C19). by Brian D Nicholson, Philip J Turner, Thomas R Fanshawe, Alice J Williams, Gayatri Amirthalingam, Sharon Tonner, Maria Zambon, Richard Body, Kerrie Davies, Rafael Perera, Simon de Lusignan, Gail N Hayward, F D Richard Hobbs, RAPTOR-C19 Study Group and the CONDOR Steering Committee

“…<h4>Methods</h4>Adults and children with symptoms consistent with suspected current COVID-19 infection were prospectively recruited from 19 UK general practices and two COVID-19 testing centres between October 2020 and October 2021. …”
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Exploring how PRIME-Parkinson care is implemented and whether, how and why it produces change, for who and under what conditions: a protocol for an embedded process evaluation within the PRIME-UK randomised controlled trial by Yoav Ben-Shlomo, Sabi Redwood, Judi Kidger, Emma Tenison, Heather Brant, Emily J Henderson, Fiona Lithander, Katherine Lloyd, Safi Smith

“…Introduction The PRIME-UK randomised controlled trial (RCT) aims to establish whether a model of care that seeks to be proactive, integrated and empower participants, caregivers and healthcare professionals can improve outcomes in people with parkinsonism. …”
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Prevalence of High Fat Sugar Salt Products, Labeling Characteristics, and Categories of Foods Sold within In-Store Restricted Areas: A Survey in 3 UK Supermarkets after the 2022 Implementation of the Food (Promotion and Placement) Regulations by Ella Hurst, Sally G Moore, Lewis W Wallis

“…Identified via the online supermarket, product nutrition and ingredient data were collected and used to categorize each as either “in” or out-of-scope of the regulations. The UK Nutrient Profiling Model was used to determine product HFSS status and the FOPNL multiple traffic light criteria used to calculate the number of inherent red traffic lights (iRTLs) possessed. …”
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