Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

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The JADES Transient Survey: Discovery and Classification of Supernovae in the JADES Deep Field by Christa DeCoursey, Eiichi Egami, Justin D. R. Pierel, Fengwu Sun, Armin Rest, David A. Coulter, Michael Engesser, Matthew R. Siebert, Kevin N. Hainline, Benjamin D. Johnson, Andrew J. Bunker, Phillip A. Cargile, Stephane Charlot, Wenlei Chen, Mirko Curti, Shea DeFour-Remy, Daniel J. Eisenstein, Ori D. Fox, Suvi Gezari, Sebastian Gomez, Jacob Jencson, Bhavin A. Joshi, Sanvi Khairnar, Jianwei Lyu, Roberto Maiolino, Takashi J. Moriya, Robert M. Quimby, George H. Rieke, Marcia J. Rieke, Brant Robertson, Melissa Shahbandeh, Louis-Gregory Strolger, Sandro Tacchella, Qinan Wang, Christina C. Williams, Christopher N. A. Willmer, Chris Willott, Yossef Zenati

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Mind the perception gap: Identifying differences in views among stakeholder groups of shared mobility services through bayesian best-worst method by Ehsan Amirnazmiafshar, Marco Diana

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Advancements in Managing Anthracycline-Induced Cardiotoxicity: Insights from Interventional Clinical Trials by Zhao M, Zhang X, Zhou D, Song J

“…Mei Zhao,1 Xiaohong Zhang,1 Dongyang Zhou,2 Junxian Song3– 5 1Department of Pharmacy, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; 3Department of Cardiology, Peking University People’s Hospital, Beijing, People’s Republic of China; 4Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, People’s Republic of China; 5Center for Cardiovascular Translational Research, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Junxian Song, Department of Cardiology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Email sjx221@163.comPurpose: Anthracycline-induced cardiotoxicity (AIC) is a significant complication in cancer treatment, impacting long-term health outcomes. …”
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Medicinal plants as alternatives for the management of hypertension and diabetes in Nigeria: Analysis of the structured interview of Nigerian patients by Rosemary A. Sylver-Francis, Olavi Pelkonen

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Temporal relationship between hospital admissions for pneumonia and weather conditions in Shanghai, China: a time-series analysis by Yuan Liu, David Rogers, Yue Zhang, Haidong Kan, Weibing Wang, Jianming Xu, Renjie Chen, Xiaofang Ye, Li Peng

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Unleashing the power of internet of things and blockchain: A comprehensive analysis and future directions by Abderahman Rejeb, Karim Rejeb, Andrea Appolloni, Sandeep Jagtap, Mohammad Iranmanesh, Salem Alghamdi, Yaser Alhasawi, Yasanur Kayikci

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Telehealth and people with disabilities in the United Kingdom: a scoping review by Mezhen Ko, Mezhen Ko, Matthew Azzopardi, Constantinos Loizou, Abison Logeswaran, Benjamin Ng, Agata Pacho, Yu Jeat Chong

“…This scoping review explores the needs, experiences, and difficulties people with disabilities face when accessing telehealth services in the United Kingdom’s (UK) National Health Service (NHS).MethodsA systematic search was conducted using the PRISMA for Scoping Reviews (PRISMA-ScR) guidelines. …”
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The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective... by Changfu Lin, Fabin Lin, Kaitai Yang, Yuxuan Zhong, Yan Luo, Hanchen Chen, Wenjing Zhang, Xuanjie Chen, Qinyong Ye, Yuqi Zeng, Guoen Cai

“…Methods We used data from the UK Biobank (UKB) to assess early-life tobacco exposure, including in utero exposure and the age at which smoking was initiated. …”
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Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics by Ruijie Xie, Teresa Seum, Sha Sha, Kira Trares, Bernd Holleczek, Hermann Brenner, Ben Schöttker

“…Methods Data from 10,257 to 1,039 patients with type 2 diabetes from the UK Biobank (UKB) and the German ESTHER cohort, respectively, were used for model derivation, internal and external validation. …”
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Reasons why osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model by George Peat, Martin J Thomas, Milica Blagojevic-Bucknall, Ross Wilkie, Simran Singh Parmar, Diane Smith, Bethany Jane Seale, Gemma Mansell

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Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics by Ilias Doulamis, Despina N. Perrea, Panagiotis E. Chatzistergos, Athanasios S. Mitousoudis, Stavros K. Kourkoulis

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The efficacy of hypothermia combined with thrombolysis or mechanical thrombectomy on acute ischemic stroke: a systematic review and meta-analysis by Dan Wang, Dan Yan, Mingmin Yan, Hao Tian, Haiwei Jiang, Bifeng Zhu, Yu Chen, Tao Peng, Yue Wan

“…Patients undergoing hypothermia for 24–48 h experienced a higher rate of overall complications (RR = 1.37, 95% CI 1.01–1.86, p = 0.04) and pneumonia (RR = 2.84, 95% CI 1.05–7.66, p = 0.04).ConclusionThe preliminary evidence supports the safety and feasibility of hypothermia combined with reperfusion therapy, which should be further investigated in randomized controlled studies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024556625.…”
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Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

“…AADCd is an ultrarare, underdiagnosed neurometabolic disorder for which a screening test (3-OMD dosing on dried blood spot (DBS)) and targeted gene therapy (authorized in the EU and the UK) are available. Therefore, it is mandatory to raise awareness of presenting symptoms and signs among practitioners. …”
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Prevalence, risk and resilience factors of mental health conditions among female sex workers: a systematic review and meta-analysis by Olivia Kalinowski, Anastasiia Lotysh, Gizem Kaya, Franziska Kroehn-Liedtke, Lena Karoline Zerbe, Hristiana Mihaylova, Krisztina Sipos, Wulf Rössler, Meryam Schouler-Ocak

“…Future research should focus on under-researched regions and subgroups within this population to enhance understanding and support the development of comprehensive health services.Systematic review registrationPROSPERO, CRD42022312737, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022312737.…”
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The PDC30 Chatbot—Development of a Psychoeducational Resource on Dementia Caregiving Among Family Caregivers: Mixed Methods Acceptability Study by Sheung-Tak Cheng, Peter H F Ng

“…Chatbot-B was constructed using PDC30 Chatbot’s architecture but replaced the latter’s knowledge base with a collection of authoritative sources, including the World Health Organization’s iSupport, By Us For Us Guides, and 185 web pages or manuals by Alzheimer’s Association, National Institute on Aging, and UK Alzheimer’s Society. In the next phase, to assess the acceptability of the PDC30 Chatbot, 21 family caregivers used the PDC30 Chatbot for two weeks and provided ratings and comments on its acceptability. …”
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Observational Signatures of Dust Traffic Jams in Polar-aligning Circumbinary Disks by Jeremy L. Smallwood, Rebecca Nealon, Hsi-Wei Yen, Christophe Pinte, Cristiano Longarini, Hossam Aly, Min-Kai Lin

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Are interventions for low-income groups effective in changing healthy eating, physical activity and smoking behaviours? A systematic review and meta-analysis by Stephan U Dombrowski, Marie Johnston, Nicola McCleary, Eleanor R Bull

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The Impact of Stigma of Loneliness on Psychological Distress in Older Adults: The Chain Mediating Effect by Fan Z, Shi X, Leng J, Cui D, Li D

“…Zhiguang Fan,1 Xiaoli Shi,2 Jiaqi Leng,3 Dan Cui,3 Deming Li4 1Department of Psychology, Shaoxing University, Shaoxing, People’s Republic of China; 2Department of Psychology, University of Exeter, Exeter, UK; 3School of English, Jilin International Studies University, Changchun, People’s Republic of China; 4Shanghai Municipal Institute for Lifelong Education, East China Normal University, Shanghai, People’s Republic of ChinaCorrespondence: Deming Li, Email lideming0513@163.comObjective: Loneliness and psychological distress are serious challenges for older adults to cope with and factors threatening life quality and happiness during their remaining years. …”
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Prevalence, determinants and knowledge about herbal medicine and non-hospital utilisation in southwest Nigeria: a cross-sectional study by Olujimi Aina, Lata Gautam, Padam Simkhada, Sarah Hall

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