Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Margherita Ambrosini, Michael J Overman, Alice Boilève, Lisa Salvatore, Rosine Guimbaud, Priya Jayachandran, Frank A Sinicrope, Thibault Mazard, Javier Ros, Vincenzo Nasca, Simon Pernot, Emily Alouani, Marie Decraecker, Emilie Hafliger, Pauline Parent

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Artificial Intelligence in Science and Society: The Vision of USERN by Tommaso Dorigo, Gary D. Brown, Carlo Casonato, Artemi Cerda, Joseph Ciarrochi, Mauro da Lio, Nicole D'Souza, Nicolas R. Gauger, Steven C. Hayes, Stefan G. Hofmann, Robert Johansson, Marcus Liwicki, Fabien Lotte, Juan J. Nieto, Giulia Olivato, Peter Parnes, George Perry, Alice Plebe, Idupulapati M. Rao, Nima Rezaei, Fredrik Sandin, Andrey Ustyuzhanin, Giorgio Vallortigara, Pietro Vischia, Niloufar Yazdanpanah

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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

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Eskişehir İl Halk Kütüphanesi Dermesinde Bulunan Resimli Çocuk Kitaplarının Fiziksel ve İçerik Özelliklerinin Ödünç Alınma Üzerinde Etkisi by Gözde Yılmaz, Bülent Yılmaz

“…Bulgular: Çalışmada elde edilen bulgulara göre, Eskişehir İl Halk Kütüphanesindeki resimli çocuk kitaplarının %60,8’inin yılda ortalama 1-3 kez ödünç alındığı; kalın karton kapaklı kitapların %56,2’si yılda ortalama 7 kez ve daha fazla ödünç alınırken, bu oranın ince kartonlu kapağa sahip kitaplar için %5,3 olduğu; özgün çocuk kitaplarının %81,9’unun, çeviri çocuk kitaplarının ise %96,6’sının ödünç alındığı; kapağı görsel çekiciliği sahip resimli çocuk kitaplarının %96,6’sı ödünç alınırken, bu oranın kapağı görsel açıdan çekici olmayan kitaplar için %81,7’ye düştüğü; çocuğun ilgi ve gereksinimlerine uygun olan kitapların %94,7’si ödünç alınırken, çocuğun gelişimine uygun olmadığı belirlenen kitaplarda ödünç alınma oranının %66,7’ye, kısmen uygun olanlarda ise %81,2’ye düştüğü; çocukta okuma isteği uyandıracak nitelikte olan resimli çocuk kitaplarının %98,2’si, kısmen bu nitelikte olanların %89,5 ve niteliksiz çocuk kitaplarının da %72,3’ü yılda en az 1 kez ödünç alındığı anlaşılmıştır. …”
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homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

“…Findings: Between June 2021 and April 2022, 68 participants across 26 U.S. states completed the study and self-collected a total of 691 and 466 longitudinal blood and nasal swab samples along with 688 symptom surveys. …”
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Peira ve Logos’un İzinde: Galenos’un Bilim Metodunun Ahlâk Felsefesine Yansıması by Hümeyra Özturan

“…Bu bağlamdaki gözlemleri Galenos’u, beden ve ahlak ilişkisini incelemeye yönlendirmiş ve bir tabip olarak beden ile ruhun birbirini etkilediğini, tecrübe ettiği vakalardan örneklerle ortaya koymuştur. …”
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β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease by Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

“…The CSF β-syn levels were measured by a commercial microfluidic ELISA. The Mann–Whitney U test and Kruskal–Wallis H test were employed to analyze two or more sets of continuous variables. …”
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Whole genome sequencing of a novel carrageenan-degrading bacterium Photobacterium rosenbergii and oligosaccharide preparation by Jing Chen, Jing Chen, Runmin Chen, Kit-Leong Cheong, Zhuo Wang, Rui Li, Xuejing Jia, Qiaoli Zhao, Xiaofei Liu, Bingbing Song, Saiyi Zhong, Saiyi Zhong

“…GDSX-4 exhibited remarkable carrageenan-degrading activity, with a specific enzyme activity of 46.94 U/mg. Optimal hydrolysis conditions were determined to be 40°C and pH 7.0, with the enzyme retaining 80% of its activity below 30°C and across a pH range of 4.0–10.0. …”
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Altitudinal patterns of bacterial communities across soil layers in the alpine meadows of the Qinghai-Tibet Plateau by Zhiyuan Chen, Yeteng Xu, Xinyue Wang, Tong Ma, Yang Liu, Xiang Qin, Wei Zhang, Tuo Chen, Guangxiu Liu, Binglin Zhang

“…The α-diversity of surface soil bacteria demonstrated a hump-shaped altitudinal trend (P < 0.05), whereas subsurface bacterial α-diversity followed a U-shaped distribution along the altitude gradient (P < 0.001). …”
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Implication of Galaxy-scale Negative Feedback by One of the Most Powerful Multiphase Outflows in a Hyperluminous Infrared Galaxy at Intermediate Redshift by Xiaoyang Chen, Masayuki Akiyama, Kohei Ichikawa, Yoshiki Toba, Toshihiro Kawaguchi, Takuma Izumi, Toshiki Saito, Daisuke Iono, Masatoshi Imanishi, Kianhong Lee, Hiroshi Nagai, Hirofumi Noda, Abdurro’uf, Mitsuru Kokubo, Naoki Matsumoto

“…Ultra- and hyperluminous IR galaxies (U/HyLIRGs) are thought to represent a transition phase of galaxies from a rapidly growing period to a quiescent status as gas is swept out by outflows, providing a laboratory in which to investigate outflows and their feedback effects on hosts. …”
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No Emergence of Colistin Resistance in the Respiratory Tract of Lung Transplant Patients Treated With Inhaled Colistin by Nathalie Grall, Nathalie Grall, Maksud Assadi, Marina Esposito-Farese, Brice Lortat-Jacob, Sébastien Tanaka, Sébastien Tanaka, Enora Atchade, Jonathan Messika, Jonathan Messika, Jonathan Messika, Vincent Bunel, Hervé Mal, Hervé Mal, Pierre Mordant, Pierre Mordant, Pierre Mordant, Yves Castier, Yves Castier, Bastien Garnier, Signara Gueye, Marie Petitjean, Erick Denamur, Laurence Armand-Lefevre, Laurence Armand-Lefevre, Charles Burdet, Philippe Montravers, Philippe Montravers, Alexy Tran-Dinh, Alexy Tran-Dinh

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Vak’anüvis Naîmâ’ya Ait Bir Ahkâm Defterinin Değerlendirilmesi by Muhammet Okudan

“…Ancak, içindeki “ahkâm” ifadesi nedeniyle birçok ilim adamı bilimler tasnifinde, İlm-i aḥkâm-ı nücûm’u, astronomiden ayrı tutmuş onu doğal ilimlerden saymamışlardır. …”
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Infrared illumination for difficult peripheral venous catheterisation in critically ill adult patients: the prospective, randomised, multicentre ICARE trial by Étienne Audureau, Sophie Demeret, Nicolas Mongardon, Damien Contou, Matthieu Schmidt, Muriel Fartoukh, Armand Mekontso Dessap, Daniel Da Silva, Frédérique Schortgen, Rachida Ouedraogo, Aline Alves, Amélie Bruant, Oumar Sy, Cécilia Tabra Osorio, Amélie Chenal, Laurence Krzyzaniak, Marianne Le Joncour, Latifa Ait Benaissa, Meriem Bouguerra, Stéphanie Tanguy Dubois, Eric Starczala, Chirine Petyt, Séverine Dezellus, Jean Francois Georger, Ann-Cécile Pallud, Damien Carras, Fabien Boussely

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Prevalence and characterization of IncQ1α-mediated multi-drug resistance in Proteus mirabilis Isolated from pigs in Kunming, Yunnan, China by Hongmei Liu, Hongmei Liu, Hongmei Liu, Na Xia, Fanan Suksawat, Bundit Tengjaroenkul, Yue Hu, Xiaofeng Zhou, Xiaojiang Li, Cuiqin Huang, Yinli Bao, Qiong Wu, Chunrong Zhang, Sunpetch Angkititrakul, Bin Xiang, Xin Wu

“…Genome analysis revealed that the repC gene was primarily associated with IncQ1α, with structural genes from other F-type plasmids (TraV, TraU, TraN, TraL, TraK, TraI, TraH, TraG, TraF, TraE/GumN, and TraA) also present. …”
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Polysaccharides from sea buckthorn — Ultrasound-assisted enzymatic extraction, purification, structural characterization, and antioxidant activity analysis by Jing Wen, Ruijie Huang, Shi Li, Lin Jiang, Liheng Shao, Qin Zhang, Chunhui Shan

“…The SBP extraction parameters were optimized, the following optimal parameters were identified: solid–liquid ratio of 1:32 g/mL, ultrasound duration of 26 min, ultrasound temperature of 52 °C, and composite enzyme concentration of 6000 U/100 mL, and the maximum extraction yield of SBP was 24.07 ± 0.15 %. …”
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Exploring the effect of cold stress on the semen quality parameters of buffalo bulls by Karpenahalli Ranganatha Sriranga, Pawan Singh, Ravinder Singh, Tejeshwari Satpute, Prince Vivek, Tushar Kumar Mohanty, Pradeep Kumar, Ranjit Singh Kataria, Megha Pande, Manishi Mukesh

“…Serum hormones such as Triiodothyronine (5.23±0.16 vs. 4.41±0.14 ng/mL, p=0.000), testosterone (0.99±0.12 vs. 1.68±0.17 ng/mL, p=0.002), cortisol (3.66±0.43 vs 2.29±0.12 ng/mL, p=0.004), and LDH (1078.54±12.32 vs 988.23±13.54 U/L, p=0.000) were affected by the cold weather. …”
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The Cognitive integrators: an Experience of the Modeling of Social Dynamics by K. E. Koktysh

“…Обозначив наличествовавшие уровни интеграции как А, В и С соответственно, а обретенные - как А1, В1 и С1, мы получим следующую принципиальную схему алгоритмов эволюции сетей, где U - изначальное «ядерное» состояние социального субъекта, когда новая иерархия и новые сети существуют исключительно в чистой потенции, а U1 - обретенное в ходе эволюции новое «ядерное» состояние, когда после сетевого периода эволюции возникает полноценная институализированная иерархия:…”
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Alternate partial root-zone irrigation combined with nitrogen fertilizer: An adaptive surge root irrigation and nitrogen strategy to improve apple yield, water-nitrogen use efficie... by Kun Hao, Wei Zhang, Shijiang Zhu, Youliang Peng, Yun Zhong, Feilong Jie, Lihua Liu, Yalin Gao, Lin Zhou, Chuang Liu, Fangyuan Shen

“…The three irrigation methods were unilateral fixed surge root irrigation (U), alternating surge root irrigation (A), and bilateral fixed surge root irrigation (B). …”
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Real-time Detection Algorithm of Expanded Feed Image on the Water Surface Based on Improved YOLOv11 by ZHOU Xiushan, WEN Luting, JIE Baifei, ZHENG Haifeng, WU Qiqi, LI Kene, LIANG Junneng, LI Yijian, WEN Jiayan, JIANG Linyuan

“…The mean average precision (mAP50) at an intersection over union (IoU) threshold of 0.5 was as high as 80.00%, and the F1-Score had also reached 79.00%. …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

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