MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer by Kari S. Wagner-Larsen, Njål Lura, Ankush Gulati, Stian Ryste, Erlend Hodneland, Kristine E. Fasmer, Kathrine Woie, Bjørn I. Bertelsen, Øyvind Salvesen, Mari K. Halle, Noeska Smit, Camilla Krakstad, Ingfrid S. Haldorsen

“…Prognostic performance of the radiomic signatures, 2018 International Federation of Gynecology and Obstetrics (FIGO) stage (I–IV), and baseline MRI-derived maximum tumor diameter (Tumormax: ≤2 cm; >2 and ≤ 4 cm; >4 cm) was evaluated by area under time-dependent receiver operating characteristics (tdROC) curves (AUC) in cohortT and cohortV (AUCT/AUCV). Mann–Whitney U tests assessed differences in radiomic delta features. …”
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Health effects of mixed metal exposure on accelerating aging among the elderly population by Chuanli Yang, Jijun Zhang, Haohan Liu, Qin Hong, Yunhe Fan, Jie An, Haijia Zhang, Xiaobing Shen, Xiushan Dong

“…However, the effects of mixed heavy metal exposure on accelerated aging in the elderly U.S. population remains unclear. This study aims to investigate the association between heavy metal concentrations in blood and urine and the onset of accelerated aging. …”
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Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics by ZHANG Yutong, HOU Guojun, SHEN Nan

“…Flow cytometry and RT-qPCR confirmed that approximately 23.1% of IPSDMs expressed CD14, and IPSDMs exhibited higher expression of monocyte-macrophage marker genes compared to the U-937 cell line. All cells in the PBDM dataset were annotated as macrophages. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

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荧光素酶标记转基因人胚胎干细胞的活体观察

“…【目的】 研究荧光素酶作为报告基因在活体定量和定位监测转基因人胚胎干细胞移植的动向的可行性65377; 【方法】 酶切pGL3 base质粒获得荧光素酶基因,酶切LTBR-uGIP获得载体骨架,连接荧光素酶基因和载体骨架构建慢病毒载体pULP,按照常规方法包装和扩增65377;ULP转导293T细胞以检测其荧光素酶的表达65377;人胚胎干细胞H9 (P40)以W3R细胞为饲养层常规培养,人胚胎干细胞转导iDuet101-IDO (吲哚胺2,3双氧化酶,IDO) 或iDuet101-CTLA4Ig(细胞毒性T细胞相关分子4免疫球蛋白,CTLA4Ig),经过筛选后再次转导ULP,即iDuet101-ULP(有荧光素酶表达)65380;iDuet 101-CTLA4Ig-ULP(有荧光素酶和CTLA4Ig表达),iDuet101-IDO-ULP(有荧光素酶和IDO表达)65377;经过2次转导的3组人胚胎干细胞分别移植于5只BALB/C小鼠(实验组,共15只)和2只RAG-/- γC-/-小鼠(对照组,共6只),在注射后当日65380;365380;565380;765380;1465380;21 d和28 d检测荧光素酶信号65377; 【结果】 在体外最少22 000个两次转导外源基因的人胚胎干细胞可检测到荧光信号65377;异种移植只需要5 × 106的细胞即可检测到荧光信号,iDuet 101-CTLA4Ig-ULP组与iDuet101-IDO-ULP组RAG-/- γC-/-小鼠在移植后荧光信号逐渐增强,观察期间逐渐上升到3 × 107电子和1.5 × 107电子, iDuet101-ULP组两只RAG-/- γC-/-小鼠在移植后第7天因伤口感染退出实验65377;3组BALB/C小鼠在第7天荧光信号消失,直到移植后两个月信号没有恢复65377; 【结论】 构建慢病毒载体共表达抗生素抗性基因和目的基因,结合W3R细胞作为饲养层细胞以筛选细胞保证外源基因的表达65377;在细胞移植免疫缺陷小鼠后,荧光素酶基因可用于活体定量和定位监测转基因人胚胎干细胞移植的动向65377;…”
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Disproportionate Distribution of HBV Genotypes A and D and the Recombinant Genotype D/E in the High and Low HBV Endemic Regions of Uganda: A Wake-Up Call for Regional Specific HBV... by Hussein Mukasa Kafeero, Dorothy Ndagire, Ponsiano Ocama, Charles Drago Kato, Eddie Wampande, Henry Kajumbula, David Kateete, Abdul Walusansa, Ali Kudamba, Kigozi Edgar, Fred Ashaba Katabazi, Maria Magdalene Namaganda, Jamilu E. Ssenku, Hakim Sendagire

“…Pearson’s chi-square, multinomial logistic regression, and Mann–Whitney U tests were used for the analysis. All the analyses were done using SPSS version 26.0 and MedCalc software version 19.1.3 at 95% CI. …”
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Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study by Camille Windsor, Adrien Joseph, Stephanie Pons, Djamel Mokart, Frederic Pène, Achille Kouatchet, Alexandre Demoule, Fabrice Bruneel, Martine Nyunga, Edith Borcoman, Matthieu Legrand, Michael Darmon, Lara Zafrani, Elie Azoulay, Virginie Lemiale

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Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

“…Furthermore, studies published after 2014 and placebo-controlled trials showed a slower rate of NRS reduction, indicating a more cautious approach to tapentadol dosing titration post the U.S. opioid crisis and in placebo-controlled contexts. …”
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Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults by Wenxin Bian, Raaj K. Biswas, Matthew N. Ahmadi, Yu Sun Bin, Svetlana Postnova, Andrew J. K. Phillips, Nicholas A. Koemel, Jean-Philippe Chaput, Shantha M. W. Rajaratnam, Peter A. Cistulli, Emmanuel Stamatakis

“…Results Over a mean follow-up of 7.9 years, 694 incident dementia cases occurred. We observed a U-shaped association between sleep duration and incident dementia, with only short sleep (< 7 h) being significantly associated with a higher risk of dementia. …”
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抑制<italic>miR</italic>-<italic>4321</italic>减轻脓毒症相关急性肾脏损伤的作用和机制研究 by 张春敏, 陈飞燕, 杨文敏, 林永敏, 毛碧涛, 陈洁, 武志远, 梁宇峰

“…利用<italic>miR-4321</italic>-Inhibitor抑制LPS诱导的HK2细胞损伤模型中<italic>miR-4321</italic>的表达，分别通过CCK-8分析、EdU染色分析和western blotting评估<italic>miR-4321</italic>对细胞增殖、细胞活力、细胞因子和凋亡相关蛋白水平的影响。…”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…Frequency distribution, dependent and independent sample t-test, Wilcoxon test, repeated measures analysis of variance, Mann Whitney U, and chi-square analysis were used to evaluate the data. …”
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The ASK-16 motorized glider: an airborne eddy covariance platform to measure turbulence, energy, and matter fluxes by I. Wiekenkamp, A. K. Lehmann, A. Bütow, J. Hartmann, S. Metzger, S. Metzger, T. Ruhtz, C. Wille, M. Zöllner, T. Sachs, T. Sachs

“…The uncertainty of <span class="inline-formula"><i>w</i></span> is between 0.15 and 0.27 m s<span class="inline-formula">⁻¹</span> (median <span class="inline-formula">=</span> 0.23 m s<span class="inline-formula">⁻¹</span>), and the uncertainty of <span class="inline-formula"><i>u</i></span> and <span class="inline-formula"><i>v</i></span> ranges between 0.16 and 0.55 m s<span class="inline-formula">⁻¹</span> (median <span class="inline-formula">=</span> 0.25 m s<span class="inline-formula">⁻¹</span>). …”
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Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…In the meantime, the prognostic value of BATF was evaluated using univariate and multivariate analyses, receiver operating characteristic (ROC) curve (AUC) analysis, and Kaplan-Meier (KM) survival analysis. EdU, colony formation, and CCK-8 assays were employed to evaluate the proliferation of cells. …”
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Comparing the Institution-based Supervision and Tele-based Supervision for Task-oriented Exercises on Upper Limb Motor Performance and Functional Ability among Stroke Patients: A R... by Neha, Subhasish Chatterjee

“…An Independent t-test or Mann-Whitney U-test will be applied based on normality to compare the changes in mean values of the outcome measures between Group A and Group B at baseline, the 4th week, and the 8th week of intervention. …”
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Şerhu Muhtasari’t-Tahâvî ve Şerhu Muhtasari’l-Kerhî’nin Şer‘î Deliller Açısından Mukayesesi by İslam Ak, Tayip Nacar

“…Cessâs şer‘î deliller bağlamında Kudûrî’den farklı olarak şer‘u men kablenâ deliline müracaat etmiştir. Cessâs’ın naklî şer‘î delilleri daha etkili kullanmasında usulcü kimliğinin önemli etkisinin olduğu anlaşılmaktadır. …”
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Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities by Ashima Thakur, Sweety Pal, Usha Sharma, Ajit Sharma, Meenakshi Choudhary, Mukesh C. Joshi, Herma Dina Setiabudi, Prabal Pratap Singh, Atheesha Singh, Sudheesh K. Shukla

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Reproductive performance of female largemouth bass (Micropterus salmoides) broodstock was enhanced by dietary small peptides by Jie Wei, Mingwei Tao, Jiaming Huang, Hangxian Zhou, Qiyou Xu

“…The contents of vitellogenin (VTG, 318.15 ± 26.15 μg/L), estradiol (E2, 42.90 ± 0.31 ng/L) and follicle-stimulating hormone (FSH, 23.04 ± 0.74 U/L) in serum were higher in the HS group than those in other groups (P < 0.05). …”
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ORGANIZACIÓN TERRITORIAL Y ACTIVIDAD GANADERA EN EL NORESTE DEL DEPARTAMENTO ALUMINÉ by Marcos D. Mare

“…La escasa infraestructura rural y la percepción del área como una zona de tránsito u obstáculo montañoso para alcanzar los destinos turísticos occidentales más promocionados, constituye un factor, hasta ahora, condicionante para una mayor diversificación socioeconómica. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

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Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…Statistical analyses included t-tests, ANOVA, and non-parametric tests like the Mann–Whitney U test or Kruskal–Wallis test. Results WMW significantly mitigates the adverse effects of a HFD on body weight and glucose metabolism in obese mice. …”
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