Simultaneous detection of human neutrophil elastase and cathepsin G on a single substrate using a fluorometric quantum dots probe and chemometric models by Fátima A.R. Mota, Rafael C. Castro, David S.M. Ribeiro, João L.M. Santos, Ricardo N.M.J. Páscoa, Marieta L.C. Passos, M. Lúcia M.F.S. Saraiva

“…These second-order data were processed using various chemometric models, including unfolded partial least-squares with residual bilinearization (U-PLS/RBL), radial basis function artificial neural network (RBF-ANN), and partial least squares-discriminant analysis (PLS-DA), to guarantee a detailed and precise analysis. …”
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Self-assessed depressive symptoms in adolescents comparing two Swedish cohorts born 15 years apart by Carl Wikberg, Pia Augustsson, Marcus Praetorius Björk, Tord Ivarsson, Gudny Sveinsdottir, Eiríkur Örn Arnarson, W. Edward Craighead, Ina Marteinsdottir, Josefine Lilja

“…The study employed a comparative analysis, using independent samples t-tests, ANOVA, and the Mann-Whitney U test for item-specific comparisons. Results: The analysis revealed no significant differences in total CDI scores between the 2004 and 2019/20 cohorts. …”
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Anomaly Detection in High Mobility MDT Traces Through Self-Supervised Learning by J. M. Sanchez-Martin, C. Gijon, M. Toril, S. Luna-Ramirez, V. Wille

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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…Atsushi Itsukaichi,* Fukumi Yoshikawa,* Ayako Fuchigami, Yoko Iwata, Genki Sato, Masahiko Miyagi, Takahisa Hirose, Hiroshi Uchino Department of Diabetes, Metabolism and Endocrinology, Toho University Graduate School of Medicine, Tokyo, Japan*These authors contributed equally to this workCorrespondence: Hiroshi Uchino, Department of Diabetes, Metabolism, and Endocrinology, Toho University Graduate School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan, Tel +81-3-3762-4151, Fax +81-3-3765-6488, Email h.uchino@med.toho-u.ac.jpPurpose: Imeglimin is a novel oral antidiabetic agent that improves glucose tolerance. …”
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Optimization of Preparation of Bioactive Peptide by Enzymatic Hydrolysis in <italic>Katsuwonus pelamis </italic>Using Response Surface Methodology and its Anti-fatigue Effect on Mi... by LI Shoujiang, KONG Xiangjia, LIU Zhiyu, ZHAO Feng, SU Yongchang, CHEN Xiaoting

“…When the solid-liquid ratio was fixed at 1∶1 (g/mL), the optimal conditions of flavor protease hydrolysis were enzyme amount 4 400 U/g, enzymatic time 6.5 h and temperature 42 ℃. …”
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Factores de riesgo relacionados con el infarto de miocardio en pacientes menores de 45 años by Luis Mariano de la Torre Fonseca, Rubén Andrés Guamán Castro, Adrian Mauricio Pacheco Naranjo, Ronald Eduardo Pucha Pesántez, Juan Sebastián Echeverría Penagos, José Roberto Calero Carreño, Robert Alarcón Cedeño

“…Las variables continuas se expresaron como media con su desviación estándar o mediana, se utilizó la prueba estadística de ji cuadrado (χ2) y la U-Mann Whitney para su procesamiento estadístico. …”
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Geometrical determinants of cerebral artery fenestration for cerebral infarction by Yuqian Mei, Xiaoqin Chen, Yao Zhang, Yanling Wang, Bo Wu, Mingcheng Hu, Quan Bao

“…The data were evaluated using either the independent sample t-test or the Mann–Whitney U test. Conducting univariate and multivariate logistic regression analyses to ascertain potential independent predictors of CI. …”
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A Local Adversarial Attack with a Maximum Aggregated Region Sparseness Strategy for 3D Objects by Ling Zhao, Xun Lv, Lili Zhu, Binyan Luo, Hang Cao, Jiahao Cui, Haifeng Li, Jian Peng

“…To minimize the attack camouflage regions, a sparseness regularization is designed to make the mask weights tend toward a U-shaped distribution and limit extreme values. …”
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Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections by Sambit Tarai, Elin Lundström, Nouman Ahmad, Robin Strand, Håkan Ahlström, Joel Kullberg

“…All the methods were independently evaluated using 5-fold cross-validation on the autoPET dataset and subsequently tested on the U-CAN dataset.Results:Combining the segmentation prior with the original SUV and CT images improved overall tumor segmentation performance significantly compared to a baseline network. …”
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Management of sleep apnoea syndrome (SAS) in patients with vasovagal syncope (VVS): a protocol for the VVS-SAS cohort study by Jean Louis Pepin, Nicolas Molinari, Frédéric Gagnadoux, Carey Meredith Suehs, Frédéric Roche, Vincent Puel, Isabelle Godard, Georgios Papaioannou, Philippe Gosse, Fabrice Thoin, Jean Claude Deharo, Naïma Zarqane

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Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas by Yu Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou

“…Results We constructed a prognostic model comprising eight genes: ALDOA, ATP5MD, SERPINH1, SFTA3, SLK, U2SURP, SCGB1A1, and SCGB1A3. The model effectively stratified patients into high- and low-risk categories, revealing that low-risk patients experienced superior clinical outcomes, exhibited an immunologically hot tumor microenvironment (TME), and had a greater probability of responding to immunotherapy. …”
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Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults by Bo Wu, Huachao Zheng, Caixiang Zhuang, Jiesheng Mao, Luo Yuncheng, Lidong Huang, Min Li, Zhao Feiyang, Sisi Lin, Pengwei Wang, Yiren Hu

“…Several statistical methods, including analysis of threshold effects, smoothed curve fitting, multiple logistic regression modeling, and subgroup analysis, were utilized to investigate the connection between GHR and gallstones.ResultsIn 3898 U.S. adults, GHR was significantly positively associated with the prevalence of gallbladder stones. …”
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TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion by Shuang Yu, Yali Yin, Shubin Hong, Siting Cao, Yanrui Huang, Shuwei Chen, Yujie Liu, Hongyu Guan, Quan Zhang, Yanbing Li, Haipeng Xiao

“…After silencing the TET1 gene with siRNAs in BCPAP and TPC-1 cells, cell proliferation was detected using EdU assay. Transwell assay was used to investigate cell migration and invasion. miRNA and mRNA expression arrays were conducted in TET1-depleted BCPAP cells. …”
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Combined Transplantation of Adipose Tissue-Derived Stem Cells and Endothelial Progenitor Cells Improve Diabetic Erectile Dysfunction in a Rat Model by Qiyun Yang, Wanmei Chen, Chi Zhang, Yun Xie, Yong Gao, Cuncan Deng, Xiangzhou Sun, Guihua Liu, Chunhua Deng

“…More 5-ethynyl-2′-deoxyuridine- (EdU-) positive EPCs could be found lining in the cavernous endothelial layer in the ADSC/EPC group than the EPC group, which was attributed to the paracrine of vascular endothelial growth factor (VEGF) and stromal-derived factor-1 (SDF-1) by ADSCs. …”
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Study on the changes and influencing factors of depression in Chinese women with cancer: an analysis based on CHARLS panel data by Na Wang, Mengran Chang, Shidong Liu, Bing Chen

“…The development trend shows an inverted “U” curve, with significant differences observed among various groups based on urban and rural residency, educational levels, and regional locations. …”
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Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease by Shiqun Chen, Yang Zhou, Guoxiao Liang, Wanying Wu, Zhigang Huang, Lile Shi, Yuwei Gao, Xia Gu, Dongmei Wang

“…Restricted cubic spline showed a U-shaped association between eGFRcr and all outcomes in patients with both reduced and supranormal eGFR levels, while a L-shaped association in eGFRcys and eGFRcr-cys.Conclusions Estimated GFR based on both creatinine and cystatin C has highest predictive effect for cardiovascular and all-cause mortality among CAD patients. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…New drug therapy approvals 2020. U.S. Food and Drug Administration. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2020#first-in-class. …”
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Scandinavia in Lithuanian Diplomacy in 1915-1917 by Sandra Grigaravičiūtė

“…Lucius) and Copenhagen (U. Brokdorf-Rantzau), which aimed to propagate the separate movement of nations of the Russian empire. …”
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Current applications and challenges in large language models for patient care: a systematic review by Felix Busch, Lena Hoffmann, Christopher Rueger, Elon HC van Dijk, Rawen Kader, Esteban Ortiz-Prado, Marcus R. Makowski, Luca Saba, Martin Hadamitzky, Jakob Nikolas Kather, Daniel Truhn, Renato Cuocolo, Lisa C. Adams, Keno K. Bressem

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Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient by Charles Gibert, Marie Wan, Matthieu Arsicot, Ugo Huvelle, Thomas Penhoat, Yatrika Koumar, Charline Miossec, Florence Persat, Florent Valour, Jean Menotti, Pauline Tirard-Collet

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