Association between fibrinogen-to-albumin ratio and bone metabolism markers (β-CTX and P1NP) in Chinese individuals with osteoporotic fracture: a cross-sectional investigation by Li-long Feng, Ke Lu, Chong Li, Min-zhe Xu, Yao-wei Ye, Yi Yin, Hui-qiang Shan

“…The study’s findings demonstrated that FAR and P1NP fit curves in an inverted U-shaped pattern, and an inflection point K = 0.0685 for FAR was detected. …”
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Actitudes hacia la investigación en médicos residentes de un hospital pediátrico público by Silvia Huaillani, Zoila Moreno-Garrido, Tamara Pando-Ezcurra, Miguel A. Noriega-Pando, Ericson L. Gutierrez, Carlos Neyra-Rivera

“…Se empleó la prueba tde Student para muestras independientes para determinar la diferencia de los puntajes de las actitudes de investigación y las variables sexo, tipo de especialidad y experiencia laboral; mientras que para la variable horas de trabajo semanal, se empleó la prueba U de Mann-Whitney. Resultados: El 58,5 % fue de sexo femenino; el 25 % (48) mostró una actitud afectiva positiva; el 98 % (196) una actitud cognitiva positiva; el 94 % (188) una actitud conductual positiva. …”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…Compound 4e was further tested for anti-cancer activity against other OS cells and showed to be equipo-tent to gedatolisib against U2OS and Saos-2 cells. Moreover, it was also found non-toxic to normal cells (BEAS-2B and MCF 10A). …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

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Effects of apple cider vinegar on glycemic control and insulin sensitivity in patients with type 2 diabetes: A GRADE-assessed systematic review and dose–response meta-analysis of c... by Donya Arjmandfard, Mehrdad Behzadi, Zahra Sohrabi, Mohsen Mohammadi Sartang

“…ACV significantly reduced fasting blood sugar (FBS) (WMD: −21.929 mg/dL, 95% CI: −29.19, −14.67, p < 0.001) and HbA1c (WMD: −1.53, 95% CI: −2.65, −0.41, p = 0.008) and increased insulin (WMD: 2.059 μu/ml, 95% CI: 0.26, 3.86, p = 0.025), while it did not affect hemostatic model assessment for insulin resistance (HOMA-IR). …”
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Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…OA also reduced 5-ethynyl-2′-deoxyuridine (EdU) incorporation into NSCs, which was indicative of inhibited NSC proliferation. …”
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Influence of Heat- and Cold-Stressed Raw Milk on the Stability of UHT Milk by Nan Li, Zhigang Yang, Zhiyu Yuan, Zizhu Zhen, Xinna Xie, Danqing Zhu, Gang Lu, Feng Zhao, Bo Qu, Bingli Qi, Yujun Jiang, Qianyu Zhao, Chaoxin Man

“…The maximum plasmin level and activity in cold-stressed milk were 607.86 μg/L and 15.99 U/L, respectively, with the beginning of gelation occurring around day 60. …”
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DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer by Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu

“…Cell proliferation and apoptosis rates and invasiveness and migratory capacities were determined by CCK-8 assays, BrdU staining assays and colony formation assays, fluorescence activated cell sorting (FACS), wound healing assays, and Transwell invasion assays of cervical cancer cells after DYNLT3 modulation. …”
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First Measurements of Ambient PM2.5 in Kinshasa, Democratic Republic of Congo and Brazzaville, Republic of Congo Using Field-calibrated Low-cost Sensors by Celeste McFarlane, Paulson Kasereka Isevulambire, Raymond Sinsi Lumbuenamo, Arnold Murphy Elouma Ndinga, Ranil Dhammapala, Xiaomeng Jin, V. Faye McNeill, Carl Malings, R. Subramanian, Daniel M. Westervelt

“…However, a few reference monitors have recently been deployed in other parts of sub-Saharan Africa, including a Met One Beta Attenuation Monitor (BAM-1020) at the U.S. Embassy in Kampala, Uganda, next to which a low-cost PM2.5 monitor, the PurpleAir, was collocated in August 2019. …”
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Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cut... by Tianqi Li, Yeshuo Ma, Ying Zhang, Yue Liu, Tingting Fu, Ri Zhang, Kai Kang, Yingchao Yang, Lixin Wang, Yinong Jiang, Yan Lu

“…The optimal cutoff value of ADRR was 2.93 (ng/dL)/(mU/L), sensitivity 80.33%, and specificity 92.11%. …”
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The ichthyofauna of the upper Neretva River by Jakob Neuburg, Thomas Friedrich, Elisabeth Haring, Sarah Höfler, Ana Maric, Saša Marić, Stephanie Popp, Predrag Simonović, Aleš Snoj, Simona Sušnik Bajec, Simon Vitecek, Alexandra Wanka, Steven Weiss, Kurt Pinter

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Propofol Priming for Enhancing Induction Safety in Hypertensive Patients: A Prospective Double-blind Randomised Controlled Trial by Tarun Yadav, Mayuri Golhar, Chhavi Saini

“…The Kolmogorov-Smirnov test was used for normalisation, and the Mann’s-Whitney U test, Independent t-test, and Chi-square test were used for data analysis. …”
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Development of the relationship between visual selective attention and auditory change detection by Yuanjun Kong, Xuye Yuan, Yiqing Hu, Bingkun Li, Dongwei Li, Jialiang Guo, Meirong Sun, Yan Song

“…ERP amplitude and decoding accuracy provided convergent evidence underlying a linear developmental trajectory for visual selective attention and an inverted U-shaped trajectory for auditory change detection from childhood to adulthood. …”
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Personalized Therapy in a Patient With EGFR-Mutated NSCLC Developing Sequential CCDC6-RET Fusion and BRAF V600E Mutation as Bypass Resistance Mechanisms by Arianna Marinello, MD, Claudia Parisi, MD, Damien Vasseur, PhD, David Combarel, PharmD, Juliette Bihoreau, NP, Pernelle Lavaud, MD, Rémy Ezzedine, MD, Lodovica Zullo, MD, Luc Friboulet, PhD, Gerard Zalcman, MD, PhD, Antoine Italiano, MD, PhD, Benjamin Besse, MD, PhD, Mihaela Aldea, MD, PhD

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Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway by Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M

“…However, the effects and mechanisms of SCU on the growth of OS remain unknown.Methods: The Cell Counting Kit-8, colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) incorporation assays were used to analyze cell proliferation ability in vitro. …”
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Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection by Simone Giuliano, Jacopo Angelini, Floriana Campanile, Paola Conti, Sarah Flammini, Alberto Pagotto, Francesco Sbrana, Luca Martini, Denise D’Elia, Mohd H. Abdul-Aziz, Menino O. Cotta, Jason A. Roberts, Robert A. Bonomo, Carlo Tascini

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Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study by Huijuan Lv, Ke Lu, Ximing Wang, Yanfang Zhang, Mengqi Zhuang, Jing Li, Keli Su, Wen Gao

“…The United States led in total publications (381) and citations (40,462), followed by China (137 articles) and Japan (102). Notably, U.S. publications had lower average citations than those from Germany and Brazil. …”
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CHAMP1 premature termination codon mutations found in individuals with intellectual disability cause a homologous recombination defect through haploinsufficiency by Yujiro Yoshizaki, Yunosuke Ouchi, Dicky Kurniawan, Eisuke Yumoto, Yuki Yoneyama, Faiza Ramadhani Rizqullah, Hiyori Sato, Mirjam Hanako Sarholz, Toyoaki Natsume, Masato T. Kanemaki, Masanori Ikeda, Ayako Ui, Kenji Iemura, Kozo Tanaka

“…When DSBs were induced in fibroblasts with PTC mutations, a defect in HR was detected. U2OS cells expressing the CHAMP1 mutants did not show an HR defect in the presence of endogenous wild-type (WT) CHAMP1, whereas they were unable to restore HR activity when CHAMP1 WT was depleted, suggesting that the PTC mutations are loss-of-function mutations. …”
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Body mass index change and estimated glomerular filtration rate decline in a middle-aged population: health check-based cohort in Japan by Rajiv Saran, Yukari Yamada, Tatsuyoshi Ikenoue, Shingo Fukuma, Jennifer Bragg-Gresham, Edward Norton, Daichi Kohmoto

“…We observed continued initial changes in BMI for over 6 years and a U-shaped association between BMI change and eGFR decline. …”
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DETERMINACIÓN DE LAS PROPIEDADES DE LA ENZIMA ALFA AMILASA PARA SU USO EN LA INDUSTRIA AZUCARERA by Saul Dueñas Casas, Jesús Luis Orozco, Héctor Luis Ramírez, Leissy Gómez Brizuela

“…Resultados y Discusión: La enzima presenta una actividad específica de 86 U/μg, los óptimos de las propiedades estructurales que se determinan son: pH 5,0, temperatura 60 ºC, una afinidad al sustrato de 6,4 g/L y una velocidad máxima de reacción de 28 571 μmol/mL×min. …”
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