Retinal Sensitivity Loss Correlates with Deep Capillary Plexus Impairment in Diabetic Macular Ischemia by Fabio Scarinci, Monica Varano, Mariacristina Parravano

“…Fourteen eyes of 12 consecutive type 2 diabetic patients with outer retinal disruption on SD-OCT showed that areas of capillary nonperfusion of the deep capillary plexus were colocalized to areas of reduced retinal sensitivity. …”
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A scoping review of shoulder kinesthetic function in individuals with diabetes mellitus, with and without frozen shoulder by Neena Varghese, Mamta S. Shetty, Rajani Prashant Mullerpatan

“…Background: Kinesthesia, the ability to perceive movements, is diminished in individuals with type II diabetes mellitus. People with frozen shoulders also experience kinesthetic deficits. …”
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The Reach of Depression Screening Preceding Treatment: Are There Patterns of Patients' Self-Selection? by Dea Ajduković, Mirjana Pibernik-Okanović, Mario Šekerija, Norbert Hermanns

“…A two-item Patient Health Questionnaire-Depression was sent to 4196 type 2 diabetic patients. Positively screened patients were interviewed to assess the severity of depression, and those with subclinical symptoms were invited to treatment groups. …”
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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…In the clinical setting, given the potential adverse effects of thiazolidinediones and biguanides, we often have difficulty in treatment that no other insulin sensitizers are available for use in type 2 diabetic mellitus (T2DM) patients. Tianmai Xiaoke Pian (TMXKP) is a traditional Chinese medicine tablet, which is comprised of chromium picolinate, Tianhuafen, Maidong, and Wuweizi. …”
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The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

“…Then, GSEA analysis revealed that glycosaminoglycan biosynthesis chondroitin sulfate, type II diabetes mellitus, and basal cell carcinoma were related with exercise samples. …”
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Extensive Prostatic Abscess in an Elderly Patient Requiring Multidisciplinary Drainage by John Michael Nesemann, Kathy Huen, Jonathan Bergman

“…We present a case of a 70-year-old man with type-two diabetes who endured two months of lower urinary tract symptoms and constipation without systemic symptoms prior to seeking medical attention. …”
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Identification and analysis of individuals who deviate from their genetically-predicted phenotype. by Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, GIANT Consortium, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood

“…Individuals whose LDL-C was higher than expected based on the genetic predictor were also at higher risk of developing coronary artery disease and type-two diabetes, even after adjustment for measured LDL-C, BMI and age, suggesting upward deviation from genetically predicted LDL-C is indicative of generally poor health. …”
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Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…Methods We designed an open randomized controlled trial comparing two treatments for pregnant women with type II diabetes mellitus (DM) and gestational diabetes (DMG): the metformin group (intervention) and the insulin group (as a routine service). …”
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To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations by Holli-Joi Sullivan, Xiaoyan Wang, Shaina Nogle, Siyan Liao, Chun Wu

“…Chiglitazar is a promising new-generation insulin sensitizer with low reverse effects for the treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan-agonist to the human peroxisome proliferator-activated receptors (PPARs) (i.e., full activation of PPARγ and a partial activation of PPARα and PPARβ/δ). …”
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Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia by Eric G. Lee, Lerin R. Luckett-Chastain, Kaitlin N. Calhoun, Benjamin Frempah, Anja Bastian, Randle M. Gallucci

“…Interleukin 6 (IL-6) plays an important role in wound healing and is known to be elevated in the serum of both type I and type II diabetes patients. This study assesses the expression and function of IL-6 in the hyperglycemic epidermis and keratinocyte culture. …”
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Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes by Amrit Chowdhary, Nicholas Jex, Sharmaine Thirunavukarasu, Amanda MacCannell, Natalie Haywood, Altaf Almutairi, Lavanya Athithan, Manali Jain, Thomas Craven, Arka Das, Noor Sharrack, Christopher E. D. Saunderson, Anshuman Sengupta, Lee Roberts, Peter Swoboda, Richard Cubbon, Klaus Witte, John Greenwood, Sven Plein, Eylem Levelt

“…Objectives. In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac magnetic resonance (CMR) and biomarker testing, during a median follow-up of 6 years, we aimed to determine longitudinal changes in the phenotypic expression of heart disease in diabetes, report clinical outcomes, and compare baseline clinical characteristics and CMR findings of patients who experienced major adverse cardiovascular events (MACE) to those remaining MACE free. …”
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Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet by Xiaolin Chen, Zhuoni Xiao, Na Dai, Mingxia Fan

“…The sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a treatment for type 2 diabetic patients, regulating adipose tissue metabolism, hypothalamic inflammation, and ovulation in women with polycystic ovary syndrome (PCOS). …”
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Mutation yellow in agouti loci prevents age-related increase of skeletal muscle genes regulating free fatty acids oxidation by Y. V. Piskunova, A. Y. Kazantceva, A. V. Baklanov, N. M. Bazhan

“…The lethal yellow mutation in agouti loci (Ay mutation) reduces the activity of melanocortin (MC) receptors and causes hyperphagia, obesity and type two diabetes mellitus in aging mice (Ay mice). It is unknown if changes in distinct elements of the metabolic system such as white adipose tissue (WAT) and brown adipose tissue (BAT), and skeletal muscle will manifest before the development of obesity. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…No change in Tusc5 mRNA or protein levels was evident in type 2 diabetic patients treated with pioglitazone. Tusc5 expression was not induced appreciably in liver preparations overexpressing PPARs, suggesting that tissue-specific factors regulate PPARγ responsiveness of the TUSC5 gene. …”
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Knockdown of Adra2a Increases Secretion of Growth Factors and Wound Healing Ability in Diabetic Adipose-Derived Stem Cells by Xiangyuan Zhao, Yong Zhang, Xinzhen Zuo, Shubai Wang, Xiao Dong

“…Studies showed that compared to normal adipose-derived stem cells (ASCs), ASCs from type 2 diabetic (T2D) mice were less effective in treating diabetic cutaneous wounds. …”
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Metformin Use and Survival in Patients with Advanced Extrahepatic Cholangiocarcinoma: A Single-Center Cohort Study in Fuyang, China by Jinqing Wu, Yabo Zhou, Guizhou Wang

“…Metformin is an oral antidiabetic agent that has been widely prescribed for the treatment of type II diabetes. In recent years, anticancer properties of metformin have been revealed for numerous human malignancies. …”
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Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene by Franklyn Nonso Iheagwam, Gaber El-Saber Batiha, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu

“…This study aims at evaluating the ameliorative role of Terminalia catappa aqueous leaf extract (TCA) on hyperglycaemia-induced oxidative stress and inflammation in a high-fat, low dose streptozotocin-induced type 2 diabetic rat model. Experimental rats were treated orally with 400 and 800 mg/kg bw TCA daily for four weeks. …”
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Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders by Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

“…Obesity-related inflammation can precipitate several diseases, such breast cancer, insulin resistance, type II diabetes and cardiovascular issues. As obesity puts human health at inherent risk, the regulation of obesity-related inflammation is therefore a necessary component to reduce disease onset, and progression, and manage symptoms. …”
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Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…Methods A Prospective cohort study designed to evaluate the effects of pharmacist intervention on prediabetes (pDG) and type II diabetes mellitus (DMG) patients. The pharmacist conducted a detailed medication review and structured patient education during the first visit, followed by an evaluation of the interventions at the second visit (after 90 days). …”
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Introduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. …”
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