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1561
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling
Published 2025-03-01“…Obesity and type 2 diabetes (T2D) are strongly linked to abnormal adipocyte metabolism and adipose tissue (AT) dysfunction. …”
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1562
The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms
Published 2025-02-01“…Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. …”
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1563
Sub-Clinical Regional Macular Changes in Self-Reported Diabetic Subjects: Vascular and Retinal Layer Analysis Using Swept-Source OCT
Published 2025-02-01“…Naveen Kumar Challa, Waleed M Alghamdi, Muhammed S Alluwimi, Saleh Alshammeri Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraidah, AlQassim, Saudi ArabiaCorrespondence: Naveen Kumar Challa, Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraidah, AlQassim, Saudi Arabia, Tel +966531177518, Email N.challa@qu.edu.saAim: To assess and compare subclinical alterations in superficial capillary plexus vessel density (SCPVD) and retinal layers thickness in the macular region between individuals with type 2 diabetes mellitus (DM) and healthy controls.Methods: Swept-source OCT images were obtained from 29 control subjects and 24 diabetic subjects. …”
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1564
NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats
Published 2019-01-01“…Clinical data has confirmed that auditory impairment may be a secondary symptom of type 2 diabetes mellitus (T2DM). However, mechanisms underlying pathologic changes that occur in the auditory system, especially in the central auditory system (CAS), remain poorly understood. …”
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1565
Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications
Published 2024-12-01“…Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease worldwide, affecting approximately 40% of individuals with type 2 diabetes (T2DM) and 30% of those with type 1 diabetes (T1DM). …”
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1566
The protective role of GLP-1 in neuro-ophthalmology
Published 2023-08-01“…Glucagon-like peptide 1 receptor agonists (GLP-1RAs), traditionally used in the treatment of type 2 diabetes, are becoming increasingly appreciated for their diverse applications. …”
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1567
Mortality and Years of Life Lost in Diabetes Mellitus and Its Subcategories in China and Its Provinces, 2005–2020
Published 2022-01-01“…The age standardized mortality rate (ASMR) of DM increased from 12.18 per 100,000 in 2005 to 13.62 per 100,000 in 2020, which was an increase of 11.86%. The ASMR of type 2 diabetes mellitus (T2DM) was much higher than that of type 1 diabetes mellitus (T1DM). …”
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1568
Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk
Published 2015-01-01“…Metabolic conditions, including type 2 diabetes, have been related to hepatocellular carcinoma (HCC) risk. …”
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1569
Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
Published 2021-01-01“…Seventy-three melioidosis patients’ records were analysed, and the most common comorbidity was type 2 diabetes mellitus (n = 53, 72.6%). The patients showed diverse presentations: pulmonary involvement, 30 (41.1%); splenomegaly, 29 (39.7%); abscesses and cutaneous involvement, 18 (24.7%); lymph node, 10 (13.7%); arthritis and osteomyelitis, 9 (12.3%); and genitourinary infection, 4 (5.4%). …”
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1570
Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa
Published 2016-01-01“…To conduct a genome-wide DNA methylation in individuals with type 2 diabetes, individuals with prediabetes, and control mixed ancestry individuals from South Africa. …”
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1571
Real-world clinical validation of the Qatar pre-diabetes risk score: a cross-sectional study
Published 2024-04-01“…Introduction Pre-diabetes stands as a prominent, independent risk factor for the onset of type 2 diabetes (T2D), with 5%–10% of individuals with pre-diabetes progressing to T2D annually. …”
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1572
<i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome
Published 2025-01-01“…Hypertension, type 2 diabetes (T2D), and obesity raise an individual’s risk of suffering from diseases associated with metabolic syndrome (MS). …”
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1573
Evaluation of the Short-Term Effect of Bariatric Surgery on the Level of HbA1c
Published 2025-01-01“…Background: Obesity is one of the most common diseases in the world, and type 2 diabetes (T2DM) is one of the common complications of obesity. …”
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1574
Perception and impact of customized physical activity programs on objective physical activity parameters in prediabetes
Published 2025-03-01“…Background: Prediabetes is an established vital risk factor for Type 2 Diabetes Mellitus (T2DM), yet an under-recognized problem. …”
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1575
Scientometric Evaluation of Research Productivity on Diabetes from the Kingdom of Saudi Arabia over the Last Two Decades (2000-2019)
Published 2020-01-01“…Diabetes, Diabetes Mellitus, and Type 2 Diabetes were the most frequently used keywords. …”
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1576
Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review
Published 2025-02-01“…Raya Bandung Sumedang KM.21 Hegarmanah, Jatinangor, Sumedang, West Java, 45363, Indonesia, Tel +62895604502223, Email nursiswati@unpad.ac.idBackground: Type 2 diabetes mellitus (T2DM), characterized by chronic hyperglycemia, leads to a decreased immune system and increased susceptibility to infections, such as tuberculosis (TB). …”
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1577
Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus: Maternal and Perinatal Outcomes
Published 2013-01-01“…Eighty-nine pregnant women (25 with type 2 diabetes and 64 with gestational diabetes mellitus; 53 under insulin lispro protamine suspension and 36 under human NPH insulin) were recruited. …”
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1578
Explainable Machine Learning for Efficient Diabetes Prediction Using Hyperparameter Tuning, SHAP Analysis, Partial Dependency, and LIME
Published 2025-01-01“…This research focused on classifying type 2 diabetes using machine learning and providing an explanation for the outcomes derived from the model predictions. …”
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1579
Evaluation of the digital diabetes prevention programme pilot: uncontrolled mixed-methods study protocol
Published 2019-05-01“…Introduction The prevalence of type 2 diabetes is rising steeply. National Health Service England (NHSE) is exploring the potential of a digital diabetes prevention programme (DDPP) and has commissioned a pilot with embedded evaluation.Methods and analysis This study aims to determine whether, and if so, how, should NHSE implement a national DDPP, using a mixed-methods pretest and post-test design, underpinned by two theoretical frameworks: the Coventry, Aberdeen and London - Refined (CALO-RE) taxonomy of behavioural change techniques for the digital interventions and the Consolidated Framework for Implementation Research (CFIR) for implementation processes. …”
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1580
The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex
Published 2025-01-01“…Background: There is a high rate of depressive symptoms such as irritability, anhedonia, fatigue, and hypersomnia in patients with type 2 diabetes mellitus (T2DM). However, the causes and underlying mechanisms of the comorbidity of depression and diabetes remain unknown. …”
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