Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…This disorder affects approximately 6–20% of individuals, primarily emerging during early adolescence, and considerably increases the risk of conditions such as impaired glucose tolerance, type 2 diabetes, endometrial cancer, cardiovascular diseases, dyslipidemia, and postpartum complications. …”
Get full text

Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota by Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, Guankui Du

“…Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. …”
Get full text

Integrating mandatory occupational health practice and workplace health promotion programs to reduce the high burden of work-related diseases by Francesco CHIRICO, Angelo SACCO, Nicola MAGNAVITA

“…Sedentary occupations and metabolic syndrome (MetS) are associated with an increased risk of type 2 diabetes mellitus (T2DM) and coronary heart disease, contributing to elevated mortality rates from CVDs. …”
Get full text

The Role of the Liver in the Pathophysiology of PCOS: A Literature Review by Abrar Alhermi, Heather Perks, Varsha Nigi, Noor Altahoo, Stephen L. Atkin, Alexandra E. Butler

“…Women with PCOS commonly have insulin resistance, increased susceptibility to type 2 diabetes mellitus, dyslipidemia, hyperinsulinemia, increased cardiovascular risk, hepatic steatosis, infertility, and an overall reduction in physical and psychological well-being. …”
Get full text

The Role of Helicobacter pylori Seropositivity in Insulin Sensitivity, Beta Cell Function, and Abnormal Glucose Tolerance by Lou Rose Malamug, Rudruidee Karnchanasorn, Raynald Samoa, Ken C. Chiu

“…Infection, for example, Helicobacter pylori (H. pylori), has been thought to play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to determine the role of H. pylori infection in glucose metabolism in an American cohort. …”
Get full text

Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing by Saskia Dymek, Lucas Jacob, Alfred Pühler, Jörn Kalinowski

“…SE50/110, is an α-glucosidase inhibitor and is used as a medication to treat type 2 diabetes. While the biosynthesis of acarbose has been elucidated, little is known about its regulation. …”
Get full text

The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy by Jingyang Wu, Jin Geng, Limin Liu, Weiping Teng, Lei Liu, Lei Chen

“…This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. …”
Get full text

The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy by Gregory A. Nichols, A. Gabriela Rosales, Teresa M. Kimes, Kaan Tunceli, Karen Kurtyka, Panagiotis Mavros

“…We conducted a observational study of 2,844 type 2 diabetes patients who initiated metformin as their first antihyperglycemic drug. …”
Get full text

Nonsevere Hypoglycemia Episode Clinical and Economic Outcomes: A Comparison between Sulfonylurea and Sodium-Glucose Cotransporter 2 Inhibitor as Add-On to Metformin from a Canadian... by Pendar Farahani

“…To estimate prevalence of NSHEs and associated economic outcomes attributable to sulfonylurea (SU) versus sodium-glucose cotransporter 2 inhibitor (SGLT2i) initiation after metformin over one year for Canadian patients with type 2 diabetes (T2DM). Methods. Risk difference for NSHEs was calculated for SU and SGLT2i from RCT data. …”
Get full text

Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Because PPAR𝛾 activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPAR𝛾 activation on steroid sex hormones in males is critical. …”
Get full text

High Fasting Plasma Glucose during Early Pregnancy: A Review about Early Gestational Diabetes Mellitus by E. Cosson, L. Carbillon, P. Valensi

“…Although eGDM is characterized by insulin resistance and associated with classical risk factors for type 2 diabetes and incident diabetes after delivery, it is not necessarily associated with preexisting prediabetes. …”
Get full text

Genetic risk factors associated with gestational diabetes in a multi-ethnic population. by Paula Benny, Hyeong Jun Ahn, Janet Burlingame, Men-Jean Lee, Corrie Miller, John Chen, Johann Urschitz

“…<h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. …”
Get full text

An Update on Less Invasive and Endoscopic Techniques Mimicking the Effect of Bariatric Surgery by Froukje J. Verdam, Ruben Schouten, Jan Willem Greve, Ger H. Koek, Nicole D. Bouvy

“…Obesity (BMI 30–35 kg/m2) and its associated disorders such as type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease have reached pandemic proportions worldwide. …”
Get full text

Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study by Maryam Mosavat, Mitra Mirsanjari, Bashir A. Lwaleed, Maherah Kamarudin, Siti Zawiah Omar

“…Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. …”
Get full text

Nomogram-Based Prediction of the Risk of Diabetic Retinopathy: A Retrospective Study by Ruohui Mo, Rong Shi, Yuhong Hu, Fan Hu

“…This study is aimed at developing a risk nomogram of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM). Methods. A questionnaire survey, biochemical indicator examination, and physical examination were performed on 4170 T2DM patients, and the collected data were used to evaluate the DR risk in T2DM patients. …”
Get full text

Extending TextAE for annotation of non-contiguous entities by Jake Lever, Russ Altman, Jin-Dong Kim

“…., the entity “type 1 diabetes” in the phrase “type 1 and type 2 diabetes.” This type is commonly found in biomedical texts, especially in lists, where multiple biomedical entities are named in shortened form to avoid repeating words. …”
Get full text

Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees by Pramod Nehete, Elizabeth R. Magden, Bharti Nehete, Patrick W. Hanley, Christian R. Abee

“…Obesity is characterized by chronic low-grade inflammation and serves as a major risk factor for hypertension, coronary artery disease, dyslipidemias, and type-2 diabetes. The purpose of this study was to examine changes in metabolic hormones, inflammatory cytokines, and immune function, in lean, overweight, and obese chimpanzees in a controlled environment. …”
Get full text

Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range by Lindor Gelin, Jiewen Li, Kathryn L. Corbin, Ishrat Jahan, Craig S. Nunemaker

“…Metformin is considered the first-line treatment for type 2 diabetes. While metformin primarily increases insulin sensitivity, evidence also suggests that metformin affects the activity of insulin-secreting pancreatic islets. …”
Get full text

Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…Main body Alogliptin is approved for treatment of type 2 diabetes mellitus (T2DM) in majority of the countries. …”
Get full text

Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions by M. Snel, J. T. Jonker, J. Schoones, H. Lamb, A. de Roos, H. Pijl, J. W. A. Smit, A. E. Meinders, I. M. Jazet

“…Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. …”
Get full text