Comprehensive management application of sulodexide on proteinuria: 2 case reports by Li Zhou, Wenge Li

“…Case 1 is a 45 years-old male with type 2 diabetes mellitus and hypertension accompanied by persistent proteinuria and intermittent edema in both legs. …”
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Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity by Joseph Fomusi Ndisang

“…A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-α), interleukin (IL-6), IL-1β and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-κB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications. Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response. …”
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Insulin Resistance: A Proinflammatory State Mediated by Lipid-Induced Signaling Dysfunction and Involved in Atherosclerotic Plaque Instability by Fabrizio Montecucco, Sabine Steffens, François Mach

“…This condition characterizes several diseases, such as type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), obesity, hypertension, dyslipidemia, and other endocrinopathies, but also cancer. …”
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Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound by Weirong Zhu, Qin Fang, Zhao Liu, Qiming Chen

“…Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. Consequently, the integrated bioinformatic analyses revealed the shared KEGG pathways between DEG-identified and diabetes-related pathways were functionally enriched in the MAPK signaling pathway, and the MAPKAPK3, HSPA2, TGFBR1, and p53 signaling pathways were involved. …”
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Metformin in the treatment of colorectal cancer and neuroendocrine tumours by Karolina Daniłowska, Natalia Picheta, Barbara I. Krupska, Anna Rudzińska, Oliwia Burdan, Katarzyna Szklener

“…Metformin, a drug commonly used in the treatment of type 2 diabetes, has demonstrated its ability to reduce the incidence and increase the efficacy of chemotherapy in colorectal cancer and neuroendocrine tumors. …”
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Current treatment landscape for obesity in Singapore by Phong Ching Lee, Chin Hong Lim, Ravishankar Asokkumar, Marvin Wei Jie Chua

“…The rising prevalence of obesity in Singapore is a harbinger for a corresponding increase in obesity-related complications such as type 2 diabetes mellitus (T2DM) and coronary heart disease. …”
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Cytokines in the Progression of Pancreatic β-Cell Dysfunction by Chunjiong Wang, Youfei Guan, Jichun Yang

“…The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. …”
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Corn phytochemicals and their health benefits by Sheng Siyuan, Li Tong, RuiHai Liu

“…Keywords: Corn, Maize, Whole grains, Phytochemicals, Cardiovascular disease, Resistant starch, Type II diabetes, Diet and chronic diseases…”
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The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity, type 2 diabetes, and cardiovascular disease. Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concentrations. …”
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Sleeve Gastrectomy and Gastroesophageal Reflux Disease by Michael Laffin, Johnny Chau, Richdeep S. Gill, Daniel W. Birch, Shahzeer Karmali

“…Although laparoscopic sleeve gastrectomy has been shown to be effective in producing weight loss and improving type 2 diabetes mellitus, its effect on gastroesophageal reflux disease (GERD) has been inconsistent. …”
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The Role of the PGC1α Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy by Samir S. Deeb, John D. Brunzell

“…Subjects with a family history of type 2 diabetes mellitus (T2DM) were more common among those who gained excessive weight. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. …”
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Stress in Obesity and Associated Metabolic and Cardiovascular Disorders by Paul Holvoet

“…Obesity has significant implications for healthcare, since it is a major risk factor for both type 2 diabetes and the metabolic syndrome. This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. …”
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Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review by Matthew R. Watson, Ceressa T. Ward, Amit Prabhakar, Babar Fiza, Vanessa Moll

“…We report a case of refractory fluoroquinolone-induced hypoglycemia in a patient with type-2 diabetes mellitus on glipizide that was successfully treated with octreotide. …”
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PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate by Robert I. Glazer, Hongyan Yuan, Zhihui Xie, Yuzhi Yin

“…PPARγ agonists are used by millions of people each year to treat type 2 diabetes but may also find additional utility as relatively nontoxic potentiators of chemotherapy. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Clinically, it has also been revealed that the existence of nonalcoholic fatty liver disease (NAFLD) enhances the incidence of type 2 diabetes mellitus (T2DM), while T2DM exacerbates NAFLD to extremely severe forms of steatohepatitis, cirrhosis, and hepatocellular carcinoma. …”
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Adropin as an indicator of T2DM and its complications by Hu Zhang, Ning Chen

“…Type 2 diabetes mellitus (T2DM) is one of metabolic diseases with the major inducer of obesity. …”
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A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications by Francesca Conserva, Loreto Gesualdo, Massimo Papale

“…Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20–40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive impairment of glomerular filtration and the development of Kimmelstiel-Wilson lesions leading to end-stage renal failure (ESRD). …”
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Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children by Anna Alisi, Nadia Panera, Carlo Agostoni, Valerio Nobili

“…This study suggested that, in children, adolescents, and adults born SGA, insulin resistance could lead to other metabolic disorders: type 2 diabetes (DM2), dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). …”
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Bariatric Surgery, Polycystic Ovary Syndrome, and Infertility by James Butterworth, Jean Deguara, Cynthia-Michelle Borg

“…Bariatric surgery has been shown to conclusively improve life expectancy, quality of life, and comorbidities like type 2 diabetes and obstructive sleep apnea. However, further research is required to identify whether weight loss surgery results in significant improvement in fertility of women with PCOS and to investigate which operation has the best results.…”
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