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1121
PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice
Published 2013-01-01“…Collectively, the present study demonstrated an inhibitory effect of PPARγ activation on renal mPGES-1/PGE2/EP4 pathway in type-2 diabetes and suggested that mPGES-1 may potentially serve as a therapeutic target for treating type-2 diabetes-associated DN.…”
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1122
Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
Published 2015-01-01“…Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. …”
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1123
Adipokines and Hepatic Insulin Resistance
Published 2013-01-01“…Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. …”
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1124
The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
Published 2015-01-01“…The type 2 diabetes pandemic in recent decades is a huge global health threat. …”
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1125
Impaired Muscle Regeneration in Ob/ob and Db/db Mice
Published 2011-01-01“…In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity. …”
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1126
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome
Published 2012-01-01“…Metabolic syndrome (MetS) represents a combination of cardiometabolic risk factors, including visceral obesity, glucose intolerance or type 2 diabetes, elevated triglycerides, reduced HDL cholesterol, and hypertension. …”
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1127
102 Jurnal Kesehatan Andalas. 2015; 4(1) Pola Komplikasi Kronis Penderita Diabetes Melitus Tipe 2 Rawat Inap di Bagian Penyakit Dalam RS. Dr. M. Djamil Padang Januari 2011 - Desemb...
Published 2015-01-01“…The objective of this study was to obtain a picture of the incidence of type 2 diabetic chronic complications. This descriptive study was conducted by taking medical record data of hospitalized type 2 diabetic patients with chronic complications inInternal Medicine Department Dr. …”
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1128
The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota
Published 2025-01-01“…In the MVMR model, the genetic connection between cigarette smoking, gut microbiota, and type 2 diabetes remained significant. Of note, paraprevotella_clara served an important mediating role in the type 2 diabetes associated with cigarette smoke. …”
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1129
Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors
Published 2024-09-01“…Sodium-glucose cotransporter type 2 inhibitors are a new class of drugs that have demonstrated cardiovascular benefits in patients with type 2 diabetes. The aim of the research was to gain insight into the efficacy of these drugs in the treatment of heart failure. …”
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1130
Quality of Life in University Students with Diabetes Distress: Type 1 and Type 2 of Diabetes Differences
Published 2022-01-01“…This study constitutes a preliminary trial to clarify the relationship between quality of life (QoL) and diabetes distress (DD in patients with diabetes mellitus (DM) by comparing patients with type 1 and type 2 diabetes. Methods. A cross-sectional study of university students with diabetes (type 1 and type 2) diabetes. …”
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1131
The Associations of Parenting Factors with Adolescent Body Mass Index in an Underserved Population
Published 2013-01-01“…Validated measures of parental perceived child risk for development of type 2 diabetes mellitus, parental limit setting for sedentary behavior, and parental nurturance were evaluated as predictors of adolescent body mass index. …”
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1132
The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Alzheimer's Disease
Published 2005-01-01“…Most brain insulin comes from the pancreas and is taken up by the brain by what appears to be a receptor-based carrier. Type 2 diabetes animal models associated with insulin resistance show reduced insulin brain uptake and content. …”
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1133
Increasing GLP-1 Circulating Levels by Bariatric Surgery or by GLP-1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different?
Published 2016-01-01“…Bariatric surgery is now proposed during the therapeutic management of type 2 diabetes in obese or overweight populations. It has been hypothesized that restoration of endogenous GLP-1 secretion after the surgery may contribute to the postsurgical resolution of diabetes. …”
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1134
Physiological and pathophysiological actions of insulin in the liver
Published 2025-02-01“…Impaired insulin receptor signaling can cause hepatic insulin resistance and lead to type 2 diabetes. In the present study, we focus on a concept called “selective insulin resistance,” which has received increasing attention recently: the frequent coexistence of hyperglycemia and hepatic steatosis in people with type 2 diabetes and obesity suggests that it is possible for the insulin signaling regulating gluconeogenesis to be impaired even while that regulating lipogenesis is preserved, suggestive of selective insulin resistance. …”
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1135
A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism
Published 2016-01-01“…While high-fat diets are associated with rising incidence of obesity/type-2 diabetes and can induce metabolic and cognitive deficits, sex-dependent comparisons are rarely systematically made. …”
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1136
Pharmacogenetics of Oral Antidiabetic Drugs
Published 2013-01-01“…Oral antidiabetic drugs (OADs) are used for more than a half-century in the treatment of type 2 diabetes. Only in the last five years, intensive research has been conducted in the pharmacogenetics of these drugs based mainly on the retrospective register studies, but only a handful of associations detected in these studies were replicated. …”
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1137
The Construction of Regulatory Network for Insulin-Mediated Genes by Integrating Methods Based on Transcription Factor Binding Motifs and Gene Expression Variations
Published 2015-09-01“…Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. …”
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1138
Previous Gestational Diabetes Mellitus and Markers of Cardiovascular Risk
Published 2012-01-01“…A history of previous GDM (pGDM), associated or not with any of these metabolic abnormalities, can increase the risk of developing not only type 2 diabetes mellitus but also cardiovascular disease (CVD) independent of a diagnosis of type 2 diabetes later in life. …”
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1139
Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats
Published 2014-01-01“…As a complicated symbiotic system, intestinal flora is reported closely related to the development of type 2 diabetes recently. Sleeve gastrectomy is one of the approaches of bariatric surgery and could improve blood glucose control in type 2 diabetes patients. …”
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1140
Association of Cardiovascular Autonomic Neuropathy and Distal Symmetric Polyneuropathy with All-Cause Mortality: A Retrospective Cohort Study
Published 2021-01-01“…Furthermore, we report a similarly strong association between DSPN and CAN and all-cause mortality in type 2 diabetes mellitus.…”
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