miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages by Zhenyu Lu, Jing Wang, Xu Wang, Zhiying Li, Dan Niu, Min Wang, Jinzhu Xiang, Yongli Yue, Yajuan Xia, Xueling Li

“…Human embryonic stem cells (hESCs) possess the ability to differentiate into insulin-producing cells (IPCs), which can be used to treat type I diabetes. miR-375 is an essential transcriptional regulator in the development and maturation of the pancreas. …”
Get full text

The Missing Heritability in T1D and Potential New Targets for Prevention by Brian G. Pierce, Ryan Eberwine, Janelle A. Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes

“…Type 1 diabetes (T1D) is a T cell-mediated disease. It is strongly associated with susceptibility haplotypes within the major histocompatibility complex, but this association accounts for an estimated 50% of susceptibility. …”
Get full text

Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers? by Katalin F. Csáki, Éva Sebestyén

“…It is also suggested that emulsifier consumption might be one of the main causes of the rising incidence of a number of diseases, such as allergic diseases, celiac disease, type I diabetes and Crohn’s disease. Moreover, it has recently been suggested that emulsifier consumption might contribute to the development of metabolic syndrome and can promote colitis-associated colorectal cancer also. …”
Get full text

Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes by Xuebao Zhang, Kezhong Zhang

“…Diabetes mellitus (DM), a metabolic disorder characterized by hyperglycemia, is caused by insufficient insulin production due to excessive loss of pancreatic β cells (type I diabetes) or impaired insulin signaling due to peripheral insulin resistance (type II diabetes). …”
Get full text

Pravastatin Improves Glucose Regulation and Biocompatibility of Agarose Encapsulated Porcine Islets following Transplantation into Pancreatectomized Dogs by Lawrence S. Gazda, Horatiu V. Vinerean, Melissa A. Laramore, Richard D. Hall, Joseph W. Carraway, Barry H. Smith

“…The encapsulation of porcine islets is an attractive methodology for the treatment of Type I diabetes. In the current study, the use of pravastatin as a mild anti-inflammatory agent was investigated in pancreatectomized diabetic canines transplanted with porcine islets encapsulated in agarose-agarose macrobeads and given 80 mg/day of pravastatin (n=3) while control animals did not receive pravastatin (n=3). …”
Get full text

Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats by Jehan Barakat Alamre, Huda Alkreathy, Ahmed S. Ali, Abdelbagi Alfadil, Sahar S. Alghamdi

“…In the current work, the wound healing effect of 3-hydrazinylquinoxaline-2-thiol hydrogel is tested topically in a full-thickness excision wound in streptozotocin-induced type 1 diabetic rats. We examined the wound closure rate, expression of inflammatory factors, growth factors in addition to the histological analysis. …”
Get full text

Clinical Evaluation of Subcutaneous Lactate Measurement in Patients after Major Cardiac Surgery by Martin Ellmerer, Martin Haluzik, Jan Blaha, Jaromir Kremen, Stepan Svacina, Andreas Plasnik, Dimas Ikeoka, Manfred Bodenlenz, Lukas Schaupp, Johannes Plank, Thomas R. Pieber

“…Minimally invasive techniques to access subcutaneous adipose tissue for glucose monitoring are successfully applied in type1 diabetic and critically ill patients. During critical illness, the addition of a lactate sensor might enhance prognosis and early intervention. …”
Get full text

Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy by Satu Vavuli, Tuire Salonurmi, Sirpa Loukovaara, Antti E. Nissinen, Markku J. Savolainen, M. Johanna Liinamaa

“…Type 2 diabetic patients had higher levels of IgA autoantibodies than type 1 diabetic patients (86.0 and 65.5, resp., p=0.004) and the highest levels in IgA were found in type 2 diabetic patients with PDR (119.1, p>0.001). …”
Get full text

Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy by Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li

“…This study is intended to explore the effect of hypoxia-inducible factor-1α (HIF-1α) activation on lipid accumulation in the diabetic kidney. A type 1 diabetic rat model was established by STZ intraperitoneal injection. …”
Get full text

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats by C. Gimenes, R. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, A. C. Cicogna, A. H. R. Takamoto, M. P. Okoshi, K. Okoshi

“…Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.…”
Get full text

Analytical Accuracy of a Continuous Glucose Monitor in Adult Diabetic KetoacidosisTake-Home Points by Nathan L. Haas, MD, Lynn Ang, MD, Nazanene H. Esfandiari, MD, Ahsan M. Khan, MBBS, James A. Cranford, PhD, Ashley Cohen, MD, Jordan Sell, MD, Mostafa Abdel-Hamid, MD, Kevin E. Romanchik, BSN, RN, Frederick K. Korley, MD, PhD

“…Mean age was 42 years, 60% were female, 70% had type I diabetes, and mean presenting pH was 7.17. Three hundred thirty-four paired measurements from CGM and POCBG measurements were analyzed. …”
Get full text