Mapping Key Populations to Develop Improved HIV and AIDS Interventions: Multiphase Cross-Sectional Observational Mapping Study Using a District and City Approach by Pande Putu Januraga, Endang Lukitosari, Lanny Luhukay, Rizky Hasby, Aang Sutrisna

“…Comparisons with ongoing outreach programs revealed substantial differences: the mapped MSM population was >50% lower than program coverage; the estimates for people who inject drugs were twice as high as the program coverage. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…Five depressed CVID patients (Hamilton Depression Rating Scale, HDRS >12) could be treated with Tα1 (8 weeks, 1.6 mg daily subcutaneously, 1st week, thereafter 1.6 mg twice weekly). At the start, at 8 weeks and 8 weeks after the last injection, the HDRS was recorded and blood samples drawn for measuring naïve and memory T cells, Th17 and Treg cells, hsCRP, IL-6 and IL-7. …”
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The hydraulic performance and clogging characteristics of a subsurface drip irrigation system operating for five years in the North China plain by Li Zaiyu, Mo Yan, Gao Hao, Gong Shihong, Zhang Yanqun, Li Guangyong, Wu Feng

“…To achieve a life of more than 20 years, additional acid/chlorine treatments, which supplement the existing system components and the current practice of flushing twice annually, are necessary.…”
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Effect of Du moxibustion in the treatment of Wind-phlegm disturbance vertigo (督灸疗法治疗眩晕风痰上扰证效果观察) by LUO Lihua (罗丽华), LI Silu (李思璐), LONG Yuqin (龙玉琴), YANG Yanni (杨燕妮), GENG Qingwen (耿庆文)

“…All patients received routine nursing during the treatment, and patients in the control group were given Du moxibustion therapy, 30 min per time, twice a week for 2 weeks. The degree of vertigo (posterior circulation ischemia) was measured before and after treatment. …”
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Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef by Marko Terzin, Steven J. Robbins, Sara C. Bell, Kim-Anh Lê Cao, Renee K. Gruber, Pedro R. Frade, Nicole S. Webster, Yun Kit Yeoh, David G. Bourne, Patrick W. Laffy

“…Results Integrating gene-centric metagenomics analyses with 17 physico-chemical variables (temperature, salinity, and particulate and dissolved nutrients) across 48 reefs revealed that associations between microbial functions and environmental parameters were twice as stable compared to taxonomy-environment associations. …”
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A cross-sectional study exploring the predictors of herpes zoster vaccination for people aged over 50 years old in Chaoyang district, Beijing by Jiao Zhang, Shuo Zhang, Bin Jia, Yunhua Bai, Zhen Li, Fang Liu, Yingxue Hu, Xiaojing Guo, Jianxin Ma, Shuming Li, Qian Shi

“…Multivariate logistic regression analysis revealed that certain factors were associated with lower vaccination coverage, including being female, having a low frequency of influenza episodes (less than twice per year), and having chronic diseases. On the other hand, higher vaccination coverage was observed among individuals whose spouses had a master’s degree or higher, those awarded that a history of chickenpox may lead to potential herpes zoster infection, those who were knowledgeable about the herpes zoster vaccine, and those received recommendations from medical staff. …”
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Exploration of the quantitative-effectiveness association between acupuncture temporal parameters and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response... by Hao Tian, Qin Luo, Liuyang Huang, Liuyang Huang, Liuyang Huang, Guang Chen, Mingsheng Sun, Fanrong Liang

“…The nonlinear dose-response analysis suggests that pain improvement achieves the MCID at 16 treatment sessions, over 8 weeks, with a frequency of twice per week. Furthermore, analysis of the treatment duration chart shows that acupuncture maintains therapeutic effects during the follow-up period. …”
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Family Rehabilitation Training by Jinyun Rehabilitation Platform in Patients with Ankylosing Spondylitis Treated by Chinese Medicine Fumigation Combined with Muscle Energy Technolo... by Longbin SHEN, Hui OUYANG, Dongling WU, Wenhao XIE

“…The anti-inflammatory painkiller was oral celecoxib, 200 mg each time, twice a day, and the treatment lasted for three weeks. …”
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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. …”
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Examining teen club attendance and viral load suppression among adolescents under differentiated HIV care in Malawi: a sub-optimal scenario by Rachel Chamanga, Tessa Musukwa, Louiser Kalitera, Felix Gent, Harrid Nkhoma, Kwashie Kudiabor, Alice Maida, Dumbani Kayira, Verita Buie, Godfrey Woelk, Thulani Maphosa

“…ALHIV with sub-optimal ART adherence were twice as likely to have unsuppressed VL (adjusted odds ratio [aOR] 2.0, 95% confidence interval (CI): 1.42–2.62) compared to those with optimal ART adherence. …”
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Effectivity of karamunting Melastoma malabathricum leaves in inhibiting ovarian development of Nile tilapia Oreochromis niloticus by Yogo Tri saloko, Muhammad Agus Suprayudi, Muhammad Zairin Jr.

“…Tilapia fish weighed 13–14 g were kept in an aquarium measuring 100×60×50 cm with a stocking density of 20 fish/ aquarium. Fish were fed twice a day at 8 a.m and 5 p.m in at satiation. Sampling was carried out at the beginning of the study, on day 30th and day 60th. …”
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Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>) by Youbin Yu, Liang Wang, Wenyun Huang, Duo Yu, Qiaoxuan Sun, Mingcao Cui

“…Large yellow croaker were fed to satiation twice daily (6:00, 17:00). At the end of this trial, the final densities were 10.38 ± 0.50, 14.41 ± 1.06, and 18.71 ± 0.99 kg/m³ in the LD, MD, and HD groups, respectively. …”
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Dust Scattering Albedo at Millimeter Wavelengths in the TW Hya Disk by Tomohiro C. Yoshida, Hideko Nomura, Takashi Tsukagoshi, Kiyoaki Doi, Kenji Furuya, Akimasa Kataoka

“…We also note that the absolute flux uncertainty of ~10% (1 σ ) is measured and used in the analysis, which is approximately twice the usually assumed value.…”
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Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells by Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli

“…Once cell have failed cell division >twice and have >8n DNA content they will continue to undergo rounds of endomitosis even in the absence of AURKBi to either become viable hyper-polyploid or die. …”
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Validity and reliability of the brief form of the normative male alexithymia scale among Chinese patients after radical prostatectomy by F. Wang, X. Zhang, L. Huang, X. Zhang, W. Jie, X. Chang, Y. Chu, L. Wang, W. Jia, B. Zhang

“…To assess test-retest reliability, 30 patients completed the survey twice. Data analysis was performed using SPSS 26.0 and AMOS 22.0. …”
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

“…Methods Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite treatment. Ketamine was dosed twice daily at 0.75 mg/kg/dose (Cohort 1) or 1.5 mg/kg/dose (Cohort 2). …”
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Bromfenac in ophthalmic practice by M.L. Maximov, A.A. Zveginceva, I.D. Kanner, N.M. Lapkin

“…Furthermore, the regimen of use (twice daily), no discomfort, and excellent safety profile with minimal adverse effects improve treatment adheren ce. …”
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A dehazing and enhancement algorithm for heterogeneous images of underground mining environments in coal mines by Xuhui ZHANG, Yanbin XIE, Wenjuan YANG, Chao ZHANG, Jicheng WAN, Zheng DONG, Yanqun WANG, Jie JIANG, Long LI

“…The results indicate that compared to the above novel and excellent algorithms in terms of their optimal indicators, the proposed algorithm exhibited that: (1) The average gradients were approximately twice those obtained by CEEF, suggesting elevated image clarity. (2) The average information entropy decreased by approximately 1% compared to that of MRP, implying more information preserved. (3) The standard deviation increased by approximately 6% on average compared to OSFD, representing improved image contrast. (4) The average fog aware density evaluator (FADE) value by approximately 23% compared to CEEF, implying an effective reduction in the haze Therefore, the proposed algorithm can effectively improve the visual effects and quality of blurred images of underground mining environments in coal mines, exhibiting high utility in engineering.…”
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Bayesian reinforcement learning models reveal how great-tailed grackles improve their behavioral flexibility in serial reversal learning experiments by Lukas, Dieter, McCune, Kelsey, Blaisdell, Aaron, Johnson-Ulrich, Zoe, MacPherson, Maggie, Seitz, Benjamin, Sevchik, August, Logan, Corina

“…Their estimated association-updating rate was more than twice as high at the end of the serial reversal learning experiment than at the beginning, and their estimated sensitivities to their learned associations declined by about a third. …”
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Testing a multi-behavioral intervention to improve oral health behaviors in the pediatric dental surgery population: protocol for the PROTECT trial by Joanna Buscemi, Teresa G. Borowski, David Avenetti, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Molly Martin, Molly Martin, Marc S. Atkins, Teresa Marshall, Michael Berbaum, Helen H. Lee, Helen H. Lee

“…Our two primary outcomes are parental assisted toothbrushing (twice/day, 2 min each time) and reduced added sugar consumption (less than 10% of overall daily caloric intake). …”
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