Spectrum and trends of cancer among HIV patients in Southwestern Uganda. by Raymond Atwine, Mitala Yekosani, Abraham Birungi, Brian Ssenkumba, Barbra Tuhamize, Richard Ezinga, Keneth Male, Taseera Kabanda

“…Participants with baseline CD4 cell count > 200 cells/μl were more than twice likely to be active in care. The Commonest ADC was Kaposi Sarcoma (KS) while the commonest NADC was Squamous cell carcinoma, Not otherwise specified. …”
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7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan by Sung-Shuo Kao, Wen-Chi Chen, Ping-I Hsu, Kwok-Hung Lai, Hsien-Chung Yu, Hui-Hwa Cheng, Nan-Jing Peng, Chiun-Ku Lin, Hoi-Hung Chan, Wei-Lun Tsai, Huay-Min Wang, Tzung-Jiun Tsai, Kung-Hung Lin, Feng-Woei Tsay

“…From March 2008 to March 2012, 319 H. pylori-infected patients receiving a 7-day pantoprazole-containing concomitant regimen (pantoprazole 40 mg, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg twice daily for 7 days) were included. Patients were asked to return at the second week to assess drug compliance and adverse effects. …”
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¿La combinación dolutegravir y rifampicina en los pacientes no incluidos en los ensayos clínicos es también eficaz y segura en el binomio VIH-infección micobacteriana? Casos de la... by Sara Fontserè Recuenco, Rafael Luque-Márquez

“…Rifampicin was administered with dolutegravir twice a day as commented. Viral suppression and mycobacterial curation were analyzed until the end of the follow-up. …”
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Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
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Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds by K. Grimm, A. Fiedler, C. Kröger

“…From Dec 2021 to Dec 2022 only one predefined hind foot of every cow was washed and sprayed with the product twice a week (treatment group), the other hind foot was only washed (control group). …”
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Perbandingan Daya Hambat Larutan Antiseptik Povidone iodine dengan Ekstrak Daun Sirih terhadap Candida albicans secara In Vitro by Septriana Putri, Aziz Djamal, Rahmatini , Cimi Ilmiawati

“…Povidone iodine solution showed twice as much as inhibitory effect on C. albicans compared to betel leaf extract (20% concentration). …”
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Ocular surface treatment in dry eye patients before corneal refractive surgery by O.A. Klokova, R.O. Damashauskas, M.S. Geidenrich

“…Standard preservative-free tear substitutes with or without a short course of steroids, lubricants, 0.05% anionic cyclosporine emulsion (twice daily), and long-term punctal plugs were prescribed for DED.…”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…Methods Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients’ subjective assessments of hair regrowth were assessed at the end of the experiment. …”
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Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study by Mohammad Abdurrehman Sheikh, Michelle P. Moon, Clinton B. Wright, Jose Gutierrez, Minghua Liu, Tatjana Rundek, Ken Cheung, Mady Hornig, Mitchell S.V. Elkind

“…The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude. Conclusion: Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. …”
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Determination of the optimal frequency and duration of micro-spray patterns for high-temperature environment tomatoes based on the Fuzzy Borda model by Run Xue, Chuan Zhang, Haofang Yan, Kinde Negessa Disasa, Imran Ali Lakhiar, Muhammad Akhlaq, Muhammad Usman Hameed, Jun Li, Jiangtao Ren, Shuaishuai Deng, Biyu Wang, Rongxuan Bao

“…Thus, this study implemented different micro-spray frequencies, F1 (once per hour) and F2 (twice per hour), and durations, D1 (1 minute), D2 (2 minutes from 11:00–13:00 and 1 minute during other times) and D3 (2 minutes) treatments to study the impact of micro-spray durations and frequencies on tomato chlorophyll fluorescence parameters, growth indicators, and fruit quality, and constructed the Fuzzy Borda combination evaluation (FB) model to obtain the optimal micro-spray treatments. …”
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Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review by Ahmed I. Edhi, Seifeldin Hakim, Christienne Shams, Damanpreet Bedi, Mitual Amin, Mitchell S. Cappell

“…A 60-year-old nonalcoholic man, with normal baseline liver function tests, was admitted with diffuse abdominal pain and AST = 499 U/L and ALT = 539 U/L, six days after completing a 7-day course of clarithromycin 500 mg twice daily for suspected upper respiratory infection. …”
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The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach by Ralph Nehme, Chiara Gini, Elise Vanbergue, Sergine Even, Filippo Biscarini, Sonia Andrés, Lucie Rault, Faustine Noel, Valerie Hardit, Said Bouhallab, David M. Pereira, Riadh Ksouri, Philippe Roussel, Secundino López, Paola Cremonesi, Bianca Castiglioni, Donatella Caruso, Fiorenza Faré, Manuela Fontana, Fabrizio Ceciliani, Latifa Abdennebi-Najar

“…Sixteen-quarters of 12 Holstein cows were selected, and TCEO was topically applied to the udder skin twice a day for 7 days. Milk was collected aseptically on days 0, 7, 21, and 28 before morning farm milking. …”
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A telehealth-delivered intervention to extend the veteran HIV treatment cascade for cardiovascular disease prevention: V-EXTRA-CVD study protocol for a randomized controlled trial by Lewis Musoke, Hayden B. Bosworth, Christina Dickson, Pamela Gentry, Elizabeth Strawbridge, Soumya Subramaniam, Jennifer Gierisch, Valerie Smith, Sandra Woolson, John Pura, Willington Amutuhaire, Susanna Naggie, Julie Schexnayder, Karen Hall, Chris T. Longenecker, Nadine M. Harris, Chantrice Rogers, Puja Van Epps, for V-EXTRA-CVD Group

“…Background: Veterans living with HIV have up to twice the risk of atherosclerotic cardiovascular disease (ASCVD) compared to those without HIV. …”
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Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomize... by Binghe Xu, Qingyuan Zhang, Yang Luo, Zhongsheng Tong, Tao Sun, Changping Shan, Xinlan Liu, Yumin Yao, Bing Zhao, Shusen Wang, Xiaohua Zeng, Changlu Hu, Xi Yan, Xiaojia Wang, Hongyan Jia, Zhendong Chen, Fuming Qiu, Xinhong Wu, Deyong Zhang, Tong Li

“…A total of 275 patients were randomized at 1:1 ratio to receive lerociclib (137 patients, 150 mg twice daily) or placebo (138 patients) plus fulvestrant. …”
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Supplementation with essential amino acids in the early stage of carbohydrate reintroduction after a very-low energy ketogenic therapy (VLEKT) improves body cell mass, muscle stren... by Giuseppe Annunziata, Ludovica Verde, Vincenzo D’Orsi, Massimiliano Caprio, Stefania Gorini, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea

“…Half of them (n = 34) followed this first step of the re-educational phase of KeNuT protocol with VLEKT with supplementation with EAAs (Aminotrofic®: 4 g twice daily). Anthropometric parameters, body composition via bioelectrical impedance analysis and high-sensitivity C-reactive protein (hs-CRP) levels were assessed at baseline, pre- and post both dietary interventions. …”
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Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms by Monika Jürgenson, Keerthana Chithanathan, Aivar Orav, Külli Jaako, Janeli Viil, Mithu Guha, Kalev Kask, Alexander Zharkovsky

“…In this study, the therapeutic potential of elocalcitol, a fluorinated derivative of vitamin D, was studied on the model of high-fat diet (HFD)-induced obesity in mice.ResultsIt was demonstrated that co-administration of elocalcitol in the doses 15 ug/kg (i.p.) twice a week for 16 weeks prevented body weight gain by approximately 15%. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…This study aimed to investigate the efficacy of combining imeglimin with dipeptidyl peptidase-4 inhibitor (DPP-4i), the most frequently prescribed first-line treatment for patients with type 2 diabetes (T2D) in Japan, to improve glycemic control.Patients and Methods: Eleven patients with T2D treated with DPP-4i alone (6.5% ≤ hemoglobin A1C [HbA1c] < 10%) received 1000 mg imeglimin twice daily for 16 weeks. A meal tolerance test (MTT) was conducted on seven of these patients to assess parameters associated with islet function or insulin tolerance, such as homeostasis model assessment (HOMA)-β-cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR), C-peptide immunoreactivity (CPR) index, and glucagon kinetics. …”
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Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

“…After CIA immunization, mice were treated twice a week by RvE1 or anti-TNF for 10 days. Arthritis development was assessed by visual scoring of paw swelling and histology of ankle joints. …”
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Analysis of Dental Enamel Surface Submitted to Fruit Juice Plus Soymilk by Micro X-Ray Fluorescence: In Vitro Study by Janaína Salmos Brito, Alexandrino Santos Neto, Luciano Silva, Rebeca Menezes, Natália Araújo, Vanda Carneiro, Lara Magalhães Moreno, Jéssica Miranda, Pâmella Álvares, Giselle Nevares, Felipe Xavier, José Alcides Arruda, Ricardo Bessa-Nogueira, Natanael Santos, Gabriela Queiroz, Ana Paula Sobral, Márcia Silveira, Diana Albuquerque, Marleny Gerbi

“…The crowns were submitted to the fruit juice plus soy during 15 days, twice a day. The pH values, acid titration, and Knoop microhardness were recorded and the specimens were evaluated using X-ray microfluorescence (µXRF). …”
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Dairy cows' responses to 2 separation methods after 3 months of cow-calf contact by Anina Vogt, Susanne Waiblinger, Rupert Palme, Uta König von Borstel, Kerstin Barth

“…Fecal and blood samples were collected twice per week from day −1 until +23 relative to separation start for analysis of fecal cortisol metabolites and the immune response. …”
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