A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices by Ashley P. Barlow, Jane He, Cindy Tian, Peter Jeffery, Stephen C. Mason, Bao-Jun Tai, Han Jiang, Gareth D. Rees, Min Quan Du

“…Subjects (N=110), stratified into two groups (N=55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. …”
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Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study by Yujiao Zheng, Fan Yang, Lin Han, Xiaowen Gou, Fengmei Lian, Wenke Liu, Linhua Zhao, Bing Pang, Xiyan Zhao, Xiaolin Tong

“…The modified HGWD treatment was administered orally twice a day for 6 months. The numerical rating scale (NRS) level at month 6 was 2.57±2.30, significantly improved compared with the baseline level of 6.03±1.83 (P<0.05). …”
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CLINICAL AND LABORATORY FEATURES OF LYME ARTHRITIS AND ARTHRITIDES OF OTHER ETIOLOGIES IN CHILDREN OF LVIV REGION by Halyna Lytvyn, Natella Basa

“…Lyme arthritis is almost twice as common in children as in adults, and is the most common manifestation of late-stage Lyme disease without the presence of erythema migrans. …”
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Association of socio-demographic characteristics, comorbidities, lifestyle habits, and saliva parameters with dental caries in adults with obesity by Virginie Chuy, Marie Mayoute, Maud Monsaingeon-Henry, Blandine Gatta-Cherifi, Élise Arrivé

“…Conclusions: Improving patients’ competencies for oral care, such as teeth brushing twice daily, is necessary to limit the burden of dental caries in individuals with obesity. …”
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Specificity of psychological readiness for changes and psychological resilience in the employees of the State Criminal-Executive Service of Ukraine by O. V. Mitroshkina

“…At the same time, in the group with high level of psychological readiness for change, there are almost twice as many interconnections between these phenomena, which indicate a more active interaction between them in this group, in contrast to the low-level group in which this interaction is rather limited. …”
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Improvement of Fatigue in Patients with Ankylosing Spondylitis Receiving Tofacitinib: Analyses of a Phase 3 Randomized Controlled Trial by Laure Gossec, Jessica A. Walsh, Raj Sengupta, Andrew G. Bushmakin, Joseph C. Cappelleri, Arne Yndestad, Oluwaseyi Dina, David Cella

“…Methods This post hoc analysis used data from a phase 3 trial (NCT03502616) in patients with active AS receiving tofacitinib 5 mg twice daily or placebo. Time to improvement in fatigue was assessed using the Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F) total score, experience domain score, and impact domain score. …”
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Effect of Visual Tracking Training combined with Six-character Formula on Motor Function and Quality of Life in Patients with Parkinson's Disease by Wanhong WANG, Hongyan BI, Zhengang QIU, Xihua LIU, He ZHUANG, Shijie HAO, Xin ZHANG, Wenyu SUN

“…Objective:To observe the effects of visual tracking training combined with six-character formula on motor function and quality of life in patients with Parkinson's disease.Methods:A total of 42 patients with Parkinson's disease treated in the affiliated hospital of Shandong university of traditional Chinese medicine were selected and divided into the control group and the observation group according to random number table method, with 21 cases in each group.The control group received routine rehabilitation training, mainly including core training, balance training, coordination training, gait training, and daily life ability training, twice a day, 45 minutes each time, five days a week, continuous training for six weeks.The observation group received visual tracking training combined with six-character formula training on the basis of the control group.Visual tracking training included thumb tracking, Whack-a-mole game, posture control, training eyeball moving as figure "8", each training for 20 minutes, once a day.Six-character formula of pronunciation training with blowing, shout, hippies, oh, boo, si breathing exercises, and cooperated with body guidance training, each training for 25 minutes, once a day.The above training for five days per week, continuous training for six weeks.The third part of the unified Parkinson's disease rating scale(UPDRS-Ⅲ)and the time up and go test(TUGT)were used to assess the patient's motor function; the balance stability limit test(AP-SD, ML-SD)was used to evaluate the patient's balance function;the Parkinson's questionnaire-39(PDQ-39)was used to evaluate the patient's quality of life.Results:Before treatment, there were no statistically significant difference in UPDRSⅢscore, AP-SD and ML-SD, TUGT time and PDQ-39 score between two groups(<italic>P</italic>&gt;0.05); Compared with before treatment, the UPDRSⅢ, AP-SD, ML-SD, TUGT and PDQ-39 scores of the two groups after treatment decreased significantly, the differences were statistically significant(<italic>P</italic>&lt;0.05); Compared with the control group, UPDRSⅢ, AP-SD, ML-SD, TUGT and PDQ-39 scores of the observation group after treatment were lower, the differences were statistically significant(<italic>P</italic>&lt;0.05).Conclusion:Visual tracking training combined with six-character formula can effectively improve the motor function and quality of life of patients with Parkinson's disease.…”
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Exploring the Functional Brain Activity of Motor Control of Abdominal Muscle Associated with Voluntary Voiding Based on Functional Near-Infrared Spectroscopy by SHI Yinshuang, WANG Menghuan, PAN Yingying, LIN Feng

“…ObjectiveThe contractions of abdominal muscle during voluntary urination is a motor control task, Which aims to explore the central activity characteristics of this action with functional near-infrared spectroscopy (fNIRS).MethodsA total of 19 healthy subjects aged 18 years or older were recruited to undergo fNIRS testing twice, performing repetitive abdominal muscle contractions in the no-urine and strong-urine states. …”
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Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations by Francisco José Toja-Camba, María Vidal-Millares, María José Durán-Maseda, Gonzalo Hermelo-Vidal, Ángel Carracedo, Olalla Maroñas, Luis Ramudo-Cela, Irene Zarra-Ferro, Anxo Fernández-Ferreiro, Cristina Mondelo-García

“…Specifically, patients with GG genotype in G2677T have almost twice the ratio compared to TT genotype. Similarly, this increase is also found in C3435T with 1.4-fold and in C1236T with 1.6-fold for the same genotypes. …”
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Effectiveness of acupuncture for equine laminitis: Systematic review and meta-analysis by Faisal Fikri, Agus Purnomo, Salipudin Tasil Maslamama, Muhammad Thohawi Elziyad Purnama

“…Conclusion: This meta-analysis enhanced the clinical studies demonstrating that twice-weekly acupuncture performed for 4 weeks consecutively can ameliorate lameness scores and a horse’s potential for recovery. …”
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Endophytic Colletotrichum siamense for Biocontrol and Resistance Induction in Guarana Seedlings by Luana L. Casas, José O. Pereira, Pedro Q. Costa-Neto, José F. Silva, Lucas N. Almeida, Roberto A. Bianco, João L. Azevedo

“…The fungicide was applied twice with an interval of 15 days between applications. …”
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Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial by Lindsay S. Nagamatsu, Alison Chan, Jennifer C. Davis, B. Lynn Beattie, Peter Graf, Michelle W. Voss, Devika Sharma, Teresa Liu-Ambrose

“…All participants exercised twice per week for six months. We measured verbal memory and learning using the Rey Auditory Verbal Learning Test (RAVLT) and spatial memory using a computerized test, before and after trial completion. …”
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Evaluating maternal drug use disparities, risk factors and outcomes in Northeast Arkansas: a pre, during, and post-COVID-19 pandemic analysis by Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

“…Mothers who smoked during pregnancy were more than twice as likely to have an MDS + result than those who did not (OR 2.39 (95% CI: 1.34–3.02), and most were from metropolitan areas (73%) or white (67%). …”
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The Effect of Zinc Supplementation on Glycemic, Weight, and Blood Pressure Control in Patients With Type 2 Diabetes Mellitus: A Double‐Blind Randomized Controlled Trial by Mehrab Sayadi, Sara Javadpour Nowbandegani, Fatemeh Balaghi Inalou, Bahman Nazemzadegan, Shirzad Javidi Alsaadi, Mohammadreza Eskandari, Matin Sepehrinia

“…Conclusion Taking 220 mg of zinc sulfate supplement twice a week did not show significant benefit for weight, blood pressure, and glycemic control in patients with Type 2 diabetes. …”
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Growth and survival of Kryptopterus lais treated with thyroxine hormone by , Agusnimar, , Rosyadi

“…Fish were fed 10% of body weight daily, given twice per day. The results showed that the treatement of P2 provided the best growth of absolute body weight and length of K. lais, the growth of absolute weight was 14.8 mg while the growth of absolute length was 1.1 cm.The best daily growth of body weight founded at P4 (0.27 %), while the best daily growth of body length were founded at P2 and P4 (0.06%). …”
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Comparative effectiveness of eimeriocidal products for treatment of broiler chickens in small scale production by A. B. Dagaeva, B. M. Makhieva

“…Group 2 chickens were given maduvet at a dose of 3−5 mg/kg of body weight with feed twice and tylosin at a dose of 5 g of powder per 10 liters of water once a day during 5 days; where necessary, the procedure was repeated in 14–16 days. …”
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Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery by Jae Hyup Lee, Jin-Hyok Kim, Jin-Hwan Kim, Hak-Sun Kim, Woo-Kie Min, Ye-Soo Park, Kyu-Yeol Lee, Jung-Hee Lee

“…Patients received once-weekly BTDS (n=47; 5 μg/h titrated to 20 μg/h) or twice-daily TA (n=40; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks. …”
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Effectiveness of 12 weeks of listening to Gayatri Mantra in the management of non-motor symptoms in patients with Parkinson’s disease: A pilot study by Puneeth Nagarajaiah, Naveen Raj GM, Anil Mohan Rao S, Sai Sailesh Kumar Goothy, Mukkadan JK

“…After recording the baseline values, the participants were asked to listen to the Gayatri Mantra 108 chanting twice a day for 12 weeks. After 12 weeks of listening, post-intervention values were recorded and analyzed. …”
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Adding Bismuth to Rabeprazole-Based First-Line Triple Therapy Does Not Improve the Eradication of Helicobacter pylori by Meng-Chieh Wu, Yao-Kuang Wang, Chung-Jung Liu, Fang-Jung Yu, Fu-Chen Kuo, Min-Li Liu, Chao-Hung Kuo, Deng-Chyang Wu, Yao-Kang Huang, I-Chen Wu

“…In the RBAK group, bismuth subcitrate 360 mg twice daily was added to the RAK regimen. A follow-up endoscopy or urea breath test was performed at least 4 weeks after eradication to confirm the treatment efficacy. …”
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Experimental evaluation of mechanically stabilized earth walls reinforced with glass fiber reinforced polymer bars embedded in marble waste-sand mixtures by Shabir Hussain, Irshad Ahmad, Irfan Jamil, Fasih Ahmed Khan, Mansoor Ullah, Saif ul Islam, Mudassir Iqbal, R. Nawaz

“…In all models maximum FD was observed at 0.31 m (z/H = 0.20) from top of the wall, while vertical settlement near the wall facing was observed to be twice as high as in the center of the model. These results underscore the potential of optimum MWS mixtures and GFRP bars in improving the structural performance and serviceability of MSE walls, highlighting their effectiveness in reducing deformations and increasing load bearing capacity, as well as enhancing sustainability and economy in MSE wall design.…”
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